Atorva E Tablet ( 10 Tablet )

ATORVA E TABLET

ATORVA E TABLET is a combination medication manufactured by ZYDUS HEALTHCARE LIMITED, primarily used for managing high cholesterol levels.

Name

• Brand Name: Atorva E Tablet
• Common Name: Atorvastatin and Ezetimibe tablets

Composition

ATORVA E TABLET contains two active ingredients:

• Atorvastatin (10 mg): This is an HMG-CoA reductase inhibitor (statin) that reduces the production of cholesterol in the liver.
• Ezetimibe (10 mg): This is a cholesterol absorption inhibitor that blocks the absorption of cholesterol from the small intestine.

Uses

ATORVA E TABLET is prescribed for the following conditions:

• Lowering high levels of total cholesterol, LDL ("bad") cholesterol, triglycerides, and apolipoprotein B.
• Boosting levels of HDL ("good") cholesterol.
• Minimizing the risk of heart attack, stroke, and other heart complications, especially in individuals with type 2 diabetes or coronary heart disease.
• Management of high cholesterol in individuals with inherited cholesterol disorders like heterozygous familial hypercholesterolemia.
• Prevention of cardiovascular issues in those with multiple risk factors.

Dosage and Administration

The daily dose of Atorva E Tablet is determined by a doctor and can vary based on individual factors. It can be taken with or without food, but it is recommended to take it regularly at evenly spaced intervals, ideally at the same time each day. The tablet should be swallowed whole and not crushed, broken, or chewed. Do not stop taking the medicine until the complete course is finished, even if feeling better.

Side Effects

Common Side Effects:

• Headache
• Fatigue or tiredness
• Nausea, stomach pain, or abdominal discomfort
• Muscle pain or weakness, and joint pain
• Diarrhoea or constipation
• Increased transaminase levels in blood
• Upper respiratory tract infection

Serious Side Effects (Seek immediate medical attention if experienced):

• Severe muscle pain that may indicate rhabdomyolysis
• Signs of liver damage such as yellowing of skin or eyes, dark urine, or unexplained bleeding/bruising
• Severe allergic reactions

Precautions

• Pregnancy and Breastfeeding: Atorva E Tablet is not recommended during pregnancy as it can harm the unborn baby and should not be used if breastfeeding.
• Liver and Kidney Conditions: Use with caution in patients with liver impairment or kidney issues. Regular monitoring of liver function is advised.
• Alcohol Consumption: Consumption of alcohol is not recommended as it can increase the risk of liver problems.
• Drug Interactions: Inform your doctor about all other medications being taken, especially immunosuppressants (like cyclosporine) and fibrates (like gemfibrozil), as they can increase the risk of muscle damage.
• Food Interactions: Avoid consuming large amounts of grapefruit juice as it can interact with atorvastatin and lead to harmful effects.
• Other Warnings: Inform your doctor if you have thyroid problems, a history of muscle disorders, or high blood pressure.

Storage

Store ATORVA E TABLET below 30°C in a cool and dry place, away from moisture and direct sunlight. Keep out of sight and reach of children.

Here are frequently asked questions about ATORVA E TABLET (Atorvastatin and Ezetimibe combination), a medication manufactured by Zydus Healthcare Limited:

What is ATORVA E TABLET used for?

ATORVA E TABLET is primarily used to treat high cholesterol levels in the blood, a condition known as hypercholesterolemia. It helps lower "bad" cholesterol (LDL), triglycerides, and apolipoprotein B, while increasing "good" cholesterol (HDL). This medication is prescribed in conjunction with a proper diet to reduce the risk of serious cardiovascular problems like heart attack and stroke, especially in individuals with type 2 diabetes, coronary heart disease, or other risk factors. It is also used to manage homozygous familial hypercholesterolemia (HoFH), an inherited form of high cholesterol.

How does ATORVA E TABLET work?

ATORVA E TABLET contains two active ingredients: Atorvastatin and Ezetimibe. Atorvastatin belongs to a class of drugs called statins (HMG-CoA reductase inhibitors). It works by reducing the production of cholesterol in the liver. Ezetimibe is a cholesterol absorption inhibitor that works by blocking the absorption of cholesterol from food and bile in the small intestine. By combining these two mechanisms, the tablet effectively reduces overall cholesterol levels in the body.

What is the usual dosage for ATORVA E TABLET?

The recommended dosage for adults (18 years and older) is typically one ATORVA E TABLET once a day. The specific strength (e.g., 10/10 mg, 10/20 mg, 10/40 mg, or 10/80 mg, referring to Ezetimibe/Atorvastatin respectively) will be determined by your doctor based on your cholesterol levels and medical condition. It's important to take the medicine exactly as prescribed by your doctor and not to exceed the recommended dose.

What are the possible side effects of ATORVA E TABLET?

Common side effects may include abdominal or stomach pain, nausea, vomiting, constipation, headache, muscle pain, joint pain, diarrhea, and flu-like symptoms. More serious, but less common, side effects can include severe muscle problems like myopathy or rhabdomyolysis (which can lead to kidney issues) and liver problems. Symptoms of serious muscle problems include unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or unusual tiredness. Signs of liver problems may include yellowing of the skin or eyes, dark urine, pale stools, loss of appetite, or pain in the upper stomach. If you experience any of these serious symptoms, contact your doctor immediately.

Is ATORVA E TABLET safe during pregnancy or breastfeeding?

No, ATORVA E TABLET is generally not safe for use during pregnancy. Statins, including atorvastatin, are classified as pregnancy category X because they can harm an unborn baby or cause birth defects, and they should be stopped as soon as pregnancy is confirmed. It is also generally not recommended to breastfeed while taking ATORVA E TABLET, as the medication may pass into breast milk and could potentially harm a nursing baby. Your doctor will advise on the best course of action.

Can ATORVA E TABLET be taken with other medications?

ATORVA E TABLET can interact with several other medications. It is crucial to inform your doctor about all medicines, vitamins, and herbal supplements you are taking. Significant interactions can occur with:

• Other cholesterol-lowering agents, such as fibrates (e.g., gemfibrozil, fenofibrate) or bile acid sequestrants (e.g., cholestyramine, colestipol). If taking bile acid sequestrants, ATORVA E TABLET should be taken at least 2 hours before or 4 hours after.
• Certain antibiotics (e.g., clarithromycin, erythromycin, fusidic acid, telithromycin) and antifungals (e.g., itraconazole).
• HIV medications (e.g., ritonavir, saquinavir) and some hepatitis C antiviral agents.
• Blood thinners like warfarin.
• Colchicine (used for gout).
• Birth control pills. Avoid consuming grapefruit or grapefruit juice as it can increase the risk of side effects.

What precautions should be taken while taking ATORVA E TABLET?

• Liver Function: Your doctor will likely perform blood tests to check your liver function before starting treatment and periodically during treatment, as this medicine can affect the liver. It should not be used if you have active liver disease or unexplained elevated liver enzymes.
• Muscle Pain: Report any unexplained muscle pain, tenderness, or weakness immediately to your doctor, especially if accompanied by fever, as this could be a sign of a serious muscle condition.
• Alcohol Consumption: Limit alcohol intake while on this medication, as heavy alcohol use can increase the risk of liver problems.
• Other Medical Conditions: Inform your doctor if you have other medical conditions such as kidney disease, diabetes, hypothyroidism (underactive thyroid), or a history of stroke or transient ischemic attack.
• Diet and Exercise: This medication should be used as an adjunct to a cholesterol-lowering diet and regular exercise.

What happens if a dose is missed?

If you miss a dose of ATORVA E TABLET, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ATORVA E TABLET be stored?

Store ATORVA E TABLET in a closed container at room temperature, away from heat, moisture, and direct light. Keep it out of the reach of children. Do not freeze the medicine. If it comes in a blister pack with a case, slide the blister card back into the case after removing a tablet to protect it from moisture and light.