R-cin 150 (10 Cap)

R-CIN 150 Capsule

Name:

• Common Name: Rifampicin
• Brand Name: R-CIN 150 (manufactured by Lupin Ltd.)

Composition:

• Each capsule contains Rifampicin 150 mg as the active ingredient.

Uses: R-CIN 150 is an antibiotic primarily used to treat various bacterial infections. Its main applications include:

• All forms of Tuberculosis (TB), often in combination with other anti-tuberculosis medications.
• Leprosy.
• Brucellosis.
• Legionnaire's disease.
• Prophylaxis against meningococcal meningitis and meningitis due to Haemophilus influenzae.
• Serious staphylococcal infections.

Dosage and Administration:

• R-CIN 150 capsules should be taken on an empty stomach, ideally one hour before or two hours after meals, to ensure optimal absorption.
• Tuberculosis:
  • Adults: Typically 10 mg/kg/day, with a maximum dose of 600 mg daily. For patients under 50 kg, 450 mg daily; over 50 kg, 600 mg daily. Dosing may also be 2-3 times per week.
  • Children: 10-20 mg/kg daily, with a maximum of 600 mg.
• Leprosy: 600 mg once monthly.
• Meningococcal meningitis prophylaxis: 600 mg twice daily for 2 days.
• Haemophilus influenzae meningitis prophylaxis: 600 mg daily for 4 days.
• It is crucial to complete the entire prescribed course of therapy, even if symptoms improve, to prevent recurrence and drug resistance.

Side Effects: Common side effects may include:

• Skin rash, itching, flushing
• Nausea, vomiting, diarrhea, anorexia, cramps, abdominal pain
• Headache, dizziness, drowsiness, confusion
• Flu-like syndrome, fever, chills
• Changes in the color of urine, sweat, tears, and other body fluids to red or orange, which is normal and harmless but can permanently stain soft contact lenses.

More serious side effects, though less common, require immediate medical attention:

• Liver problems (hepatitis, jaundice, dark urine, pale stools)
• Severe allergic reactions (swelling of face, lips, tongue, difficulty breathing)
• Severe skin reactions (e.g., Stevens-Johnson Syndrome)
• Unusual bruising or bleeding, thrombocytopenia (low blood platelets)

Precautions:

• R-CIN 150 is contraindicated in individuals with hypersensitivity to rifampicin or other rifamycins, and in patients with jaundice.
• Use with caution in patients with a history of alcoholism, hepatic or renal impairment, elderly patients, malnourished individuals, and children under 2 years of age.
• Pregnancy and lactation: Not generally recommended or should be used with caution, as it may affect the unborn baby and passes into breast milk. Physical birth control methods are advised as Rifampicin can reduce the effectiveness of oral contraceptives.
• Drug interactions: R-CIN 150 can accelerate the metabolism of many drugs (e.g., quinidine, phenytoin, theophylline), reducing their effectiveness. Antacids should not be taken within 1-2 hours of R-CIN 150 as they can reduce its absorption. Concurrent use with saquinavir/ritonavir can increase the risk of hepatotoxicity.
• Avoid alcohol consumption as it may increase the risk of liver damage and drowsiness.
• Patients should be monitored for liver function (AST, ALT, bilirubin) and complete blood count (CBC) during treatment.
• May cause dizziness; caution is advised when driving or operating machinery.

Storage:

• Store in a cool and dry place, protected from light and moisture.
• Maintain a storage temperature between 15°C to 30°C.
• Keep out of sight and reach of children.

R-CIN 150 (10 CAP) by Lupin Ltd. contains Rifampicin, an antibiotic primarily used to treat various bacterial infections, including tuberculosis and leprosy.

What is R-CIN 150 used for?

R-CIN 150 is an antibiotic medication primarily used to treat bacterial infections such as tuberculosis (TB), which mainly affects the lungs but can also spread to other body parts. It is also used to treat leprosy, brucellosis, Legionnaire's disease, and serious staphylococcal infections. Additionally, it can be used for prophylaxis against meningococcal meningitis and infections due to Haemophilus influenzae.

How does R-CIN 150 work?

R-CIN 150 works by inhibiting the growth and spread of bacteria. Its active ingredient, Rifampicin, binds to the beta subunit of DNA-dependent RNA polymerase in susceptible bacteria, thereby blocking RNA synthesis and preventing the bacteria from producing essential proteins for their survival and replication. This mechanism leads to the elimination of the infection.

What is the usual dosage of R-CIN 150?

The dosage of R-CIN 150 is determined by your doctor based on the specific infection, your age, weight, and medical condition. Generally, for adults with tuberculosis, the recommended daily dose is 10 mg/kg, not exceeding 600 mg per day. For patients weighing less than 50 kg, 450 mg daily is common, and for those 50 kg or more, 600 mg daily. It should be taken on an empty stomach, ideally 1 hour before or 2 hours after meals, with a full glass of water, to ensure optimal absorption.

What are the possible side effects of R-CIN 150?

Common side effects of R-CIN 150 include nausea, vomiting, diarrhea, loss of appetite (anorexia), abdominal pain, headache, dizziness, and skin rash. A notable, harmless side effect is the reddish-orange discoloration of urine, faeces, sweat, saliva, sputum, tears, and other body fluids. More serious, though less common, side effects can include liver problems (hepatotoxicity), allergic reactions, flu-like syndrome, and blood abnormalities such as thrombocytopenia (low blood platelets).

Is R-CIN 150 safe during pregnancy or breastfeeding?

R-CIN 150 is generally not recommended for use during pregnancy as it may harm the developing fetus and can lead to complications for both mother and baby after birth. Pregnant women should discuss the benefits and risks with their doctor. For breastfeeding women, R-CIN 150 is typically not recommended because a small amount of the medication can pass into breast milk. However, some sources suggest it may be safe if prescribed by a doctor, as human studies indicate it does not pass into breast milk in significant amounts and is not harmful to the baby. Always consult your doctor if you are pregnant or breastfeeding.

Can R-CIN 150 be taken with other medications?

R-CIN 150 can interact with many other medications, potentially accelerating their metabolism and reducing their effectiveness. It is known to decrease the effectiveness of oral contraceptives (birth control pills), so alternative birth control methods should be used. It can also interact with blood thinners like warfarin, antiretroviral drugs used for HIV treatment, quinidine, phenytoin, theophylline, atovaquone, ketoconazole, and enalaprilat. Antacids should not be taken within 1 to 2 hours of R-CIN 150 as they can reduce its absorption. Always inform your doctor about all other medications you are taking to avoid harmful interactions.

What precautions should be taken?

Several precautions should be taken while on R-CIN 150. Patients with a history of alcoholism, hepatic (liver) and renal (kidney) impairment, or diabetes should use this medicine with caution and under strict medical supervision. It is also advised to avoid wearing soft contact lenses as the medication can permanently stain them. R-CIN 150 may cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you. It's crucial to complete the full course of treatment as prescribed, even if you start feeling better, to prevent the infection from returning or becoming drug-resistant.

What happens if a dose is missed?

If you miss a dose of R-CIN 150, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

R-CIN 150 should be stored in a cool and dry place, protected from light and moisture, typically between 15-30°C. Keep it out of sight and reach of children.