Rapeed D Capsule (10 Cap)

RAPEED D CAPSULE (10 CAP) by ALKEM LABORATORIES LTD.

Name

Common Name: Rabeprazole and Domperidone Capsules Brand Name: RAPEED D CAPSULE

Composition

RAPEED D CAPSULE is a fixed-dose combination medication containing two active ingredients:

• Rabeprazole (20 mg): A proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach.
• Domperidone (30 mg): A dopamine antagonist and prokinetic agent that improves stomach and bowel contractions, increasing the movement of food through the digestive system and reducing symptoms like nausea and bloating.

Uses

RAPEED D CAPSULE is primarily used to manage gastroesophageal reflux disease (GERD), especially in patients who have not responded adequately to rabeprazole alone. It is also prescribed for:

• Peptic ulcers, including those caused by H. pylori infection or NSAID use.
• Dyspepsia (indigestion) and non-ulcer dyspepsia.
• Gastroparesis, a condition where the stomach takes too long to empty its contents.
• Zollinger-Ellison syndrome.

Dosage and Administration

This medicine should be taken orally as a whole capsule, without crushing, chewing, or breaking it. It is typically recommended to take RAPEED D CAPSULE 30 minutes before food, preferably in the morning before breakfast. The exact dosage and duration should be strictly followed as advised by a doctor.

Side Effects

Common Side Effects:

• Headache
• Dizziness
• Diarrhea
• Nausea
• Abdominal pain
• Flatulence (excessive gas)
• Dry mouth
• Rash

Serious Side Effects (Consult a doctor immediately if experienced):

• Severe allergic reactions (sudden wheezing, swelling of lips, face or body, rash, fainting, or difficulty swallowing)
• Symptoms of liver problems (yellow skin, dark urine, and tiredness)
• Severe skin reactions (e.g., Stevens-Johnson syndrome)
• Seizures
• QT prolongation (a heart rhythm condition)

Precautions

• Pregnancy and Breastfeeding: Not generally recommended during pregnancy, especially in the first trimester, and should be used with caution during breastfeeding as domperidone can pass into breast milk.
• Alcohol: Avoid alcohol consumption as it may increase the risk of side effects like dizziness and drowsiness and can worsen acidity.
• Liver and Kidney Impairment: Use with caution in patients with liver or severe kidney problems.
• Heart Problems: Avoid if you have existing heart conditions due to the risk of QT prolongation.
• Drug Interactions: Inform your doctor about all other medications, including supplements and herbal products, to prevent interactions with anticholinergics, antacids, H2 blockers, and certain CYP3A4 inhibitors.
• Other Warnings: Prolonged use may lead to deficiencies of Vitamin B12, calcium, magnesium, and Vitamin D, increasing the risk of osteoporosis. Not recommended for children below 5-16 years depending on sources.

Storage

Store RAPEED D CAPSULE below 25°C or 30°C in a cool and dry place. Keep it away from moisture, heat, direct sunlight, and out of the sight and reach of children and pets.

What is Rapeed D Capsule used for?

Rapeed D Capsule is primarily used to manage gastroesophageal reflux disease (GERD), a condition where stomach acid frequently flows back into the food pipe, causing heartburn and discomfort. It is also used to treat indigestion (dyspepsia), gastroparesis (delayed stomach emptying), peptic ulcers, and Zollinger-Ellison syndrome (a condition causing excessive stomach acid production).

How does Rapeed D Capsule work?

Rapeed D Capsule contains two active ingredients: Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach by blocking an enzyme responsible for acid secretion. Domperidone is a prokinetic agent that increases the movement of the stomach and intestines, helping food move through the digestive system more effectively and reducing symptoms like nausea, bloating, and reflux by tightening the lower esophageal sphincter.

What is the usual dosage for Rapeed D Capsule?

Rapeed D Capsule is typically taken once daily, 30 minutes before a meal, preferably in the morning. The capsule usually contains 20 mg of Rabeprazole and 30 mg of Domperidone. It should be swallowed whole with water and not crushed, chewed, or broken. Always follow your doctor's prescribed dosage and duration of treatment.

What are the possible side effects of Rapeed D Capsule?

Common side effects can include headache, dizziness, diarrhea, nausea, abdominal pain, flatulence, dry mouth, rash, vomiting, and joint pain. Most of these are temporary and resolve over time. More serious but rare side effects can include heart rhythm conditions (QT prolongation), kidney damage, severe allergic reactions, liver problems, or seizures. If you experience any severe or persistent side effects, consult your doctor immediately.

Is Rapeed D Capsule safe during pregnancy or breastfeeding?

During pregnancy: Caution is advised when taking Rapeed D Capsule if you are pregnant, especially during the first trimester. Some sources advise consulting a doctor as it may be unsafe or even contraindicated, while others state it can be taken safely with doctor's approval. Therefore, it is crucial to consult your doctor before taking this medicine if you are pregnant or planning a pregnancy.

During breastfeeding: Rapeed D Capsule might not be suitable if you are breastfeeding, as domperidone, one of its ingredients, is known to pass into breast milk. While some sources report no evidence of risk, others state it is probably unsafe or contraindicated. Always consult your doctor to weigh the benefits and potential risks before using this medication while breastfeeding.

Can Rapeed D Capsule be taken with other medications?

Rapeed D Capsule can interact with several medications. Inform your doctor about all medicines, supplements, and herbal products you are currently taking. Interactions can occur with:

• Anticholinergics
• Antacids and H2 blockers (take Rapeed D 1-2 hours apart)
• Ketoconazole and other CYP3A4 inhibitors
• Blood thinners
• Antifungals
• Anti-HIV drugs
• Iron supplements
• Anti-cancer medications
• Certain heart medicines, especially those for irregular heartbeat
• Antidepressants known as MAOIs
• Other mood medicines

Your doctor can advise on necessary adjustments or alternative therapies.

What precautions should be taken while using Rapeed D Capsule?

• Medical Conditions: Inform your doctor if you have existing heart problems, Parkinson's disease, osteoporosis, liver or kidney problems, stomach or intestinal cancer, low magnesium levels, or allergies to any components of the medicine.
• Alcohol: It is advisable to avoid or limit alcohol intake as it can worsen GERD symptoms and may increase side effects like dizziness and drowsiness.
• Driving/Machinery: This medication may cause dizziness or sleepiness, so avoid driving or operating heavy machinery until you know how it affects you.
• Long-term use: Prolonged intake may lead to deficiencies of Vitamin B12, calcium, magnesium, and Vitamin D, potentially increasing the risk of bone fractures (osteoporosis).
• Diet: Avoid spicy, fatty, fried, caffeinated, carbonated, and acidic foods, as they can aggravate GERD symptoms.
• Children: Rapeed D Capsule is generally not recommended for use in children below 16 or 18 years of age due to a lack of safety and effectiveness data.

What happens if a dose of Rapeed D Capsule is missed?

If you miss a dose of Rapeed D Capsule, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Rapeed D Capsule be stored?

Store Rapeed D Capsule at room temperature, typically between 10°C to 30°C (or below 25°C), in a cool and dry place. Protect it from moisture, heat, and direct sunlight. Keep the medicine out of the sight and reach of children and pets.