Maczone Plus 1.5mg Inj

MACZONE PLUS 1.5MG INJ is an antibiotic medication manufactured by Macleods Pharmaceuticals Ltd.

Name

Brand Name: MACZONE PLUS 1.5MG INJ, MACZONE PLUS 1.5GM INJECTION

Composition

MACZONE PLUS 1.5MG INJ is a combination of two active ingredients:

• Ceftriaxone: 1000 mg (1 gm)
• Sulbactam: 500 mg

Ceftriaxone is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis, while Sulbactam is a beta-lactamase inhibitor that prevents bacteria from destroying Ceftriaxone, thereby enhancing its activity.

Uses

This injection is prescribed for the management of various bacterial infections, including:

• Infections of the brain (meningitis)
• Lung infections
• Middle ear infections (acute bacterial otitis media)
• Abdominal and abdominal wall infections (peritonitis)
• Urinary tract and kidney infections
• Bone and joint infections
• Skin or soft tissue infections
• Blood infections
• Heart infections
• Sexually transmitted infections (gonorrhoea and syphilis)
• Fever in patients with low white blood cell counts (neutropenia) due to bacterial infection
• Lyme disease
• Prevention of infections during surgery (surgical prophylaxis)

Dosage and Administration

MACZONE PLUS 1.5MG INJ is administered by a healthcare professional, either intravenously (into a vein) or intramuscularly (into a muscle). The appropriate dose and duration of treatment are determined by the doctor based on the patient's age, body weight, and the severity of the infection. It is crucial to complete the full course of treatment even if symptoms improve to ensure complete eradication of the infection.

Side Effects

Common Side Effects:

• Diarrhea
• Rash and itching
• Pain, tenderness, warmth, or tightness at the injection site
• Nausea and vomiting
• Changes in liver function tests
• Low blood cell counts
• Headache, weakness, or dizziness

Serious Side Effects (Contact your doctor immediately if experienced):

• Allergic reactions such as hives, severe rash, blistering, difficulty breathing, or swelling of the face, lips, tongue, or throat
• Severe or bloody diarrhea

Precautions

• Allergies: Do not use if allergic to ceftriaxone, sulbactam, penicillin, or similar antibiotics.
• Pediatric Use: Not recommended for premature babies or newborns with jaundice.
• Pregnancy and Breastfeeding: Use with caution; consult a doctor.
• Elderly Patients: Use with caution.
• Medical Conditions: Inform your doctor if you have kidney disease (e.g., kidney stones), liver disease, gut problems (like colitis), pancreatitis, hemolytic anemia, gall bladder stones, or if you are scheduled for blood or urine tests.
• Interactions: Avoid concurrent use with calcium-containing diluents (e.g., Ringer's solution) and inform your doctor about all other medications, including antifungals, blood clot medications, and oral contraceptives.

Storage

Keep MACZONE PLUS 1.5GM INJECTION out of reach of children. Store it below 30°C.

What is MACZONE PLUS 1.5MG INJ used for?

MACZONE PLUS 1.5GM INJECTION is an antibiotic used to manage various bacterial infections throughout the body. These include infections of the brain (meningitis), lungs, middle ear, abdomen and abdominal wall (peritonitis), urinary tract and kidneys, bones and joints, skin or soft tissues, blood, and heart. It can also be used for specific sexually transmitted infections like gonorrhea and syphilis, in patients with low white blood cell counts (neutropenia) who have a fever due to bacterial infection, for Lyme disease, and to prevent infections during surgery.

How does MACZONE PLUS 1.5MG INJ work?

MACZONE PLUS 1.5GM INJECTION is a combination of two medicines: Ceftriaxone and Sulbactam. Ceftriaxone is a cephalosporin antibiotic that works by inhibiting the synthesis of bacterial cell walls, which ultimately leads to the destruction of the bacteria. Sulbactam is a beta-lactamase inhibitor that prevents bacteria from developing resistance by binding to and inhibiting the beta-lactamase enzyme that bacteria produce to destroy antibiotics.

What is the usual dosage of MACZONE PLUS 1.5MG INJ?

The dosage and duration of MACZONE PLUS 1.5GM INJECTION are determined by a doctor based on the patient's age, body weight, and the severity of the infection. It is administered by a doctor or nurse as an intravenous injection or infusion, or as an intramuscular injection.

What are the possible side effects of MACZONE PLUS 1.5MG INJ?

Common side effects include diarrhea, rash, itching, pain, tenderness, warmth, or tightness at the injection site, and inflammation of a vein due to blood clots. Other possible side effects can include nausea, vomiting, indigestion, headache, weakness, dizziness, changes in liver function tests, and changes in blood cell counts. Rarely, severe allergic reactions can occur, characterized by swelling of the face, lips, throat, or tongue, difficulty breathing, skin blistering, or high fever.

Is MACZONE PLUS 1.5MG INJ safe during pregnancy or breastfeeding?

MACZONE PLUS 1.5GM INJECTION should be used with caution during pregnancy and breastfeeding. It is generally considered safe for use in pregnancy when prescribed by an expert, though there are limited human studies. For breastfeeding mothers, it should be used with caution, and breastfeeding might need to be held until the treatment is completed and the drug is eliminated from the body. It is always best to consult your doctor if you are pregnant or breastfeeding.

Can MACZONE PLUS 1.5MG INJ be taken with other medications?

Inform your doctor about all medications you are currently taking before receiving MACZONE PLUS 1.5GM INJECTION. It can interact with medicines used to manage blood cancer (e.g., amacrine), certain other antibiotics (e.g., vancomycin, chloramphenicol, tobramycin, gentamycin), antifungal medications (e.g., fluconazole), oral contraceptives, medicines to manage blood clots (e.g., dabigatran, rivaroxaban), and medicines for gout (e.g., probenecid). It should not be mixed with calcium-containing diluents.

What precautions should be taken with MACZONE PLUS 1.5MG INJ?

MACZONE PLUS 1.5GM INJECTION is not recommended for premature babies or newborns with jaundice. It should be used with caution in elderly patients and in individuals with kidney disease (such as kidney stones) or liver disease. Patients with a known allergy to ceftriaxone, sulbactam, penicillin, or similar antibiotics should not receive this medicine. If you experience dizziness after receiving the injection, avoid driving or operating machinery.

What happens if a dose of MACZONE PLUS 1.5MG INJ is missed?

Since MACZONE PLUS 1.5GM INJECTION is administered by a healthcare professional, it is unlikely that a dose will be missed. However, if a scheduled dose is missed, it's advisable to consult your doctor. Do not take a double dose to make up for a missed one.

How should MACZONE PLUS 1.5MG INJ be stored?

MACZONE PLUS 1.5GM INJECTION should be kept out of reach of children and stored below 30°C.