Glyduo 10/100 Tablet

GLYDUO 10/100 Tablet

GLYDUO 10/100 Tablet is a prescription medicine manufactured by Intas Pharmaceuticals Ltd., used for the management of type 2 diabetes mellitus in adults.

• Composition

  • Dapagliflozin: 10 mg
  • Vildagliptin: 100 mg

• Uses GLYDUO 10/100 Tablet is prescribed to improve blood sugar control in adults with type 2 diabetes mellitus, typically when diet and exercise alone, or metformin monotherapy, are insufficient. It also helps reduce the risk of kidney disease and cardiovascular death in type 2 diabetic patients.

• Dosage and Administration Take GLYDUO 10/100 Tablet exactly as directed by your doctor. It can be taken with or without food, preferably at the same time each day to maintain consistent blood sugar levels. Swallow the tablet whole; do not crush, chew, or break it. Do not stop taking the medication without consulting your doctor.

• Side Effects

  • Common Side Effects: Hypoglycaemia (low blood sugar), genital yeast infections, urinary tract infections, nausea, diarrhoea, increased urination, abdominal discomfort, dizziness, headache, back pain, rash, and fatigue.
  • Serious Side Effects (Seek immediate medical attention): Swelling of the face, throat or tongue (angioedema), trouble swallowing or breathing, severe stomach pain that may radiate to the back (pancreatitis), or symptoms of liver inflammation (yellowing of skin/eyes, dark urine).

• Precautions Do not use GLYDUO 10/100 Tablet if you have a known allergy to dapagliflozin, vildagliptin, or any other ingredients. It is not recommended for individuals with severe kidney disease, type 1 diabetes, or metabolic acidosis, including diabetic ketoacidosis. Inform your doctor if you have kidney or liver issues, heart problems, hypertension, or a history of urinary tract infections. Avoid excessive alcohol consumption as it can increase the risk of low blood sugar and lactic acidosis. Exercise caution when driving or operating machinery due to potential dizziness. This medicine is not recommended for children under 18 years of age. Consult your doctor if you are pregnant or breastfeeding. Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements, diuretics, insulin, or insulin secretagogues. Maintaining good hygiene and staying well-hydrated can help prevent certain side effects.

• Storage Store GLYDUO 10/100 Tablet in its original packaging at room temperature, typically between 15-30°C (or below 30°C), away from direct heat, sunlight, and moisture. Keep this medicine out of the sight and reach of children.

What is GLYDUO 10/100 Tablet used for?

GLYDUO 10/100 Tablet is a combination medicine primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed when diet and exercise alone, or a single medication, are not sufficient to achieve adequate blood sugar control. Beyond blood sugar management, it also helps reduce the risk of cardiovascular death and hospitalization due to heart failure, and can assist in treating chronic kidney disease associated with type 2 diabetes.

How does GLYDUO 10/100 Tablet work?

GLYDUO 10/100 Tablet contains two active ingredients: Dapagliflozin and Vildagliptin. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, leading to the excretion of excess sugar through the urine. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the body's natural hormones (incretins) to increase insulin release after meals and decrease the amount of glucose produced by the liver, especially when blood sugar is high. These two mechanisms work synergistically to improve glycemic control.

What is the usual dosage for GLYDUO 10/100 Tablet?

The dosage of GLYDUO 10/100 Tablet is determined by your doctor based on individual patient factors, including the severity of diabetes, current blood sugar levels, and overall health. It is typically taken once or twice daily, usually with meals to help minimize gastrointestinal side effects. It is crucial to follow your doctor's instructions precisely regarding the dosage and timing. Do not crush, chew, or break the tablet, and try to take it at the same time(s) each day for consistent blood sugar levels.

What are the possible side effects of GLYDUO 10/100 Tablet?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, stomach upset, headache, dizziness, increased urination, and hypoglycemia (low blood sugar), especially if taken with other diabetes medications. Other common side effects can include genital infections (like thrush) and urinary tract infections (UTIs) due to the action of dapagliflozin, along with back pain, rash, fatigue, and increased thirst. Rarely, more serious side effects such as lactic acidosis, liver problems, allergic reactions (e.g., swelling of face, lips, tongue), or inflammation of the pancreas can occur. Consult your doctor if any side effects persist or become severe.

Is GLYDUO 10/100 Tablet safe during pregnancy or breastfeeding?

It is generally not recommended to take GLYDUO 10/100 Tablet during pregnancy or while breastfeeding due to insufficient data on its safety and potential risks to the fetus or infant. If you are pregnant, planning to become pregnant, or breastfeeding, you should consult your healthcare provider to discuss the risks and alternative treatment options.

Can GLYDUO 10/100 Tablet be taken with other medications?

GLYDUO 10/100 Tablet can interact with certain medications. It is important to inform your doctor about all prescription and over-the-counter drugs, as well as herbal supplements and vitamins you are currently taking. Particular caution is advised with other medicines that lower blood sugar (like insulin or sulfonylureas), diuretics (water pills), corticosteroids (used to reduce inflammation), thyroid medications, and certain anti-seizure medications, as these can affect the efficacy or increase the risk of side effects.

What precautions should be taken while using GLYDUO 10/100 Tablet?

Before starting GLYDUO 10/100 Tablet, inform your doctor about any existing medical conditions, especially kidney or liver problems, heart disease, hypertension, or a history of urinary tract infections. Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis. This medicine is not recommended for children. If you experience dizziness as a side effect, exercise caution when driving or operating machinery. It's also important to stay well-hydrated and maintain good hygiene to reduce the risk of genital and urinary tract infections. Do not stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.

What happens if a dose of GLYDUO 10/100 Tablet is missed?

If you miss a dose of GLYDUO 10/100 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can increase the risk of side effects.

How should GLYDUO 10/100 Tablet be stored?

GLYDUO 10/100 Tablet should be stored in its original packaging at room temperature, typically between 15-30°C (or below 30°C). Keep it in a cool, dry place, away from direct heat, sunlight, and moisture. Always ensure the medicine is kept out of the sight and reach of children.