Fosfocin Sachet

FOSFOCIN SACHET

FOSFOCIN SACHET, manufactured by ARISTO PHARMACEUTICALS PVT LTD, is an antibiotic primarily used for treating specific bacterial infections.

• Name:

  • Common Name: Fosfomycin
  • Brand Name: Fosfocin Sachet

• Composition:

  • Each sachet contains Fosfomycin Trometamol, equivalent to 3 grams of Fosfomycin.

• Uses: FOSFOCIN SACHET is indicated for the treatment of acute uncomplicated lower urinary tract infections (acute cystitis) in women aged 18 years and older. It targets susceptible strains of Escherichia coli and Enterococcus faecalis. It works by inhibiting bacterial cell wall synthesis and reducing bacterial adherence to uroepithelial cells in the bladder. It may also be used as an antibiotic prophylaxis for transrectal prostate biopsy in men.

• Dosage and Administration: The recommended dosage for uncomplicated urinary tract infections in women 18 years and older is one sachet (3 gm) as a single dose. The entire contents of the sachet should be dissolved in 3 to 4 ounces (approximately ½ cup) of water and consumed immediately; do not use hot water or take it in dry form. It can be taken with or without food, preferably on an empty stomach, either one hour before or two hours after meals, ideally at bedtime after emptying the bladder. Do not exceed a single dose for one episode of acute cystitis.

• Side Effects: Common side effects include headache, dizziness, diarrhea (which can sometimes be severe), vaginal inflammation (vaginitis), nausea, indigestion, abdominal pain, and rash. Serious but rare side effects can include severe allergic reactions such as anaphylactic shock or angioedema, and Clostridium difficile-associated diarrhea (CDAD).

• Precautions: FOSFOCIN SACHET is contraindicated in patients with known hypersensitivity to fosfomycin or severe kidney problems. Caution is advised in pregnant or breastfeeding women, and consultation with a doctor is essential. Avoid alcohol and caffeinated drinks, as they may worsen symptoms or side effects like dizziness. This medicine may cause dizziness or sleepiness, so avoid driving or operating machinery if affected. Metoclopramide and other drugs increasing gastrointestinal motility may reduce the effectiveness of Fosfocin.

• Storage: Store FOSFOCIN SACHET at room temperature below 25°C, in a cool, dry place, protected from light. Keep out of reach of children.

What is Fosfocin Sachet used for?

Fosfocin Sachet is an antibiotic primarily used to treat uncomplicated bacterial infections of the urinary tract (UTIs) in women, specifically acute cystitis caused by susceptible strains of Escherichia coli and Enterococcus faecalis. It can also be prescribed for asymptomatic bacteriuria (bacteria in the urine without symptoms of infection) in pregnant women and for prophylaxis (prevention) of urinary infections following a transrectal prostate biopsy in men.

How does Fosfocin Sachet work?

Fosfocin Sachet contains fosfomycin trometamol, which is a broad-spectrum antibiotic. It works by killing bacteria through a unique mechanism: it irreversibly inhibits an enzyme called UDP-N-acetylglucosamine-enolpyruvyltransferase (MurA), which is essential for the bacteria to build their cell walls. By preventing the formation of the bacterial cell wall, it leads to bacterial cell lysis and death. It also helps reduce the ability of bacteria to attach to the cells lining the urinary bladder.

What is the usual dosage of Fosfocin Sachet?

For uncomplicated urinary tract infections in women aged 18 years and older, the recommended dosage is one sachet (3g) taken orally as a single dose. The contents of the sachet should be poured into 3 to 4 ounces (about ½ cup or 100 ml) of cold water, stirred to dissolve completely, and then drunk immediately. It can be taken with or without food, but some recommendations suggest taking it on an empty stomach, either one hour before or at least two hours after meals, preferably at bedtime after emptying the bladder. It is crucial not to use more than one single dose to treat a single episode of acute cystitis, as repeated doses do not improve efficacy but can increase side effects.

What are the possible side effects of Fosfocin Sachet?

Common side effects include headache, dizziness, diarrhea, nausea, vomiting, indigestion, abdominal pain, and vaginitis (inflammation, irritation, or itching of the female genital organs). Other less common side effects can include skin rash, back pain, rhinitis, and pharyngitis. In rare cases, more serious side effects can occur, such as severe diarrhea (Clostridium difficile-associated diarrhea), severe allergic reactions (e.g., swelling of the face, lips, tongue, or throat; difficulty breathing), or, in instances of overdose, vestibular loss, impaired hearing, or a metallic taste. If any severe or persistent side effects occur, medical attention should be sought.

Is Fosfocin Sachet safe during pregnancy or breastfeeding?

During Pregnancy: Fosfocin Sachet is generally not recommended for use during pregnancy unless specifically considered necessary by a doctor, who will weigh the potential risks and benefits. It is classified as Pregnancy Category B. However, it can be indicated for cases where bacteria are found in the urine during pregnancy, even if the mother does not have symptoms of infection. During Breastfeeding: It is not recommended for use by breastfeeding women because the medicine may pass into breast milk. A decision should be made in consultation with a doctor whether to discontinue nursing or to not administer the drug, taking into account the importance of the medicine to the mother.

Can Fosfocin Sachet be taken with other medications?

Fosfocin Sachet can interact with other medications. For example, co-administration with metoclopramide, a drug that increases gastrointestinal motility, can decrease the blood concentration and urinary excretion of fosfomycin. Other drugs that increase gastrointestinal motility might have similar effects. There can also be interactions with anticoagulants, where their ability to prevent blood clotting might be altered. Urinary alkalinisers (such as Ural) or acidic drinks (like cranberry juice) can change the acidity of urine and potentially interfere with how Fosfocin works. Additionally, there are serious interactions with certain vaccines, including BCG vaccine live, cholera vaccine, and typhoid vaccine live. It is important to inform your doctor about all other medicines and supplements you are taking.

What precautions should be taken while using Fosfocin Sachet?

Several precautions should be observed when taking Fosfocin Sachet. Avoid taking this medicine if you have a known allergy to fosfomycin. Caution is advised for patients with kidney problems, especially severe impairment or those undergoing hemodialysis, as the medicine is excreted by the kidneys and could accumulate in the body. It should also be used with caution if you have a history of stomach and intestinal issues, particularly colitis, as it may worsen these conditions or lead to Clostridium difficile-associated diarrhea. Due to potential dizziness, avoid driving or operating heavy machinery until you know how the medicine affects you. It is also advisable to avoid alcohol and caffeinated drinks. Always complete the entire prescribed course of treatment, even if symptoms improve quickly, to ensure the infection is fully resolved and to prevent the development of antibiotic resistance. If your symptoms do not improve within 2 to 3 days after taking the medicine, contact your doctor.

What happens if a dose of Fosfocin Sachet is missed?

Fosfocin Sachet is typically prescribed as a single-dose treatment. However, if for any reason a dose is missed, you should take it as soon as you remember. If it is almost time for your next dose (though this is unlikely for a single-dose medication), it is generally advised to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Fosfocin Sachet be stored?

Fosfocin Sachet should be stored at room temperature, ideally below 25°C or between 15-30°C, in a cool and dry place. It is important to protect the sachet from light and keep it out of the reach of children and pets. The powder should remain in its original package until you are ready to mix your dose.