Ziglim Plus 1 Tablet

ZIGLIM PLUS 1 TABLET

ZIGLIM PLUS 1 TABLET is a combination medicine manufactured by FDC Ltd, designed for the comprehensive management of type 2 diabetes mellitus. It is available as a sustained-release (SR) tablet.

Composition Each ZIGLIM PLUS 1 TABLET (SR) contains a blend of three active antidiabetic ingredients:

• Glimepiride (1mg)
• Metformin Hydrochloride (500mg) (Sustained Release)
• Pioglitazone (15mg)

Uses ZIGLIM PLUS 1 TABLET is primarily prescribed to control blood sugar levels in adults with type 2 diabetes mellitus, especially when diet and exercise alone, or a single or dual therapy, are insufficient. It works by stimulating the pancreas to produce more insulin, reducing sugar production in the liver, delaying sugar absorption from the intestines, and increasing the body's sensitivity to insulin. This helps in the proper utilization of insulin, thereby lowering blood sugar levels and reducing the risk of associated complications like nerve, kidney, eye, and cardiovascular problems.

Dosage and Administration This medicine should be taken orally in the dose and duration advised by your doctor. It must be taken with food to prevent stomach upset. Swallow the tablet whole; do not chew, crush, or break it. If a dose is missed, take it as soon as possible. However, if it's almost time for the next dose, skip the missed one and continue with the regular schedule. Do not double the dose. Regular monitoring of blood sugar levels is crucial.

Side Effects Common side effects may include:

• Hypoglycemia (low blood glucose level), especially if meals are skipped, alcohol is consumed, or with excessive exercise.
• Nausea, diarrhea, stomach pain, vomiting.
• Headache, dizziness, weakness.
• Anemia.
• Sinus or respiratory tract infections.
• Metallic taste, weight gain, bone fractures.

Serious side effects, though rare, can include lactic acidosis (muscle pain, fatigue, difficulty breathing), liver problems (yellowing of skin or eyes), and heart failure.

Precautions

• Alcohol: Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and serious complications like ketoacidosis.
• Pregnancy and Breastfeeding: Not recommended during pregnancy as it may harm the unborn baby. Consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
• Medical Conditions: Inform your doctor if you have kidney, liver, or heart problems (including congestive heart failure), eye problems, hormonal imbalance, or are malnourished. It is contraindicated in severe kidney or liver failure, class III or IV heart failure, and metabolic acidosis.
• Driving: May affect your ability to drive due to fluctuating blood sugar levels (hypoglycemia or hyperglycemia).
• Vitamin B12 Deficiency: Long-term use may cause vitamin B12 deficiency due to metformin.
• Interactions: Inform your doctor about all prescription and non-prescription medicines, vitamins, and herbal supplements you are taking to avoid potential drug interactions.

Storage Store ZIGLIM PLUS 1 TABLET below 30°C in a cool and dry place, away from heat, moisture, and direct sunlight. Keep it out of the reach of children and pets.

ZIGLIM PLUS 1 TABLET by FDC LTD is a combination medication primarily used for the management of type 2 diabetes mellitus. It contains three active ingredients: Glimepiride, Metformin, and Pioglitazone, which work together to help control blood sugar levels when diet, exercise, or single/dual therapy are not sufficient.

Here are some frequently asked questions about ZIGLIM PLUS 1 TABLET:

What is ZIGLIM PLUS 1 TABLET used for?

ZIGLIM PLUS 1 TABLET is used to treat type 2 diabetes mellitus in adults, especially when blood sugar levels are not adequately controlled by diet and exercise alone, or with other antidiabetic medications. It helps to improve blood sugar control.

How does ZIGLIM PLUS 1 TABLET work?

This medicine combines three different antidiabetic agents to manage blood sugar:

• Glimepiride: A sulfonylurea that stimulates the pancreas to release more insulin.
• Metformin: A biguanide that reduces glucose production in the liver, delays sugar absorption from the intestines, and increases the body's sensitivity to insulin.
• Pioglitazone: A thiazolidinedione that increases the sensitivity of liver, muscle, and fat cells to insulin, enabling them to remove glucose more effectively from the blood. Together, these components improve glucose uptake, lower insulin resistance, and control both fasting and post-meal sugar levels.

What is the usual dosage for ZIGLIM PLUS 1 TABLET?

ZIGLIM PLUS 1 TABLET should be taken in the dose and duration advised by your doctor. It is typically taken once or twice daily, preferably with meals, to reduce the risk of stomach upset. Do not chew, crush, or break the tablet. Your doctor will determine the correct dosage based on your age, body weight, and disease condition.

What are the possible side effects of ZIGLIM PLUS 1 TABLET?

Common side effects may include hypoglycemia (low blood sugar), stomach pain, nausea, diarrhea, vomiting, headache, dizziness, metallic taste, muscle pain, and weight gain. Less common but serious side effects can include lactic acidosis, heart failure symptoms, and liver problems. If side effects persist or worsen, or if you experience severe symptoms like cold hands/feet, unusual muscle pain, or trouble breathing, contact your doctor immediately.

Is ZIGLIM PLUS 1 TABLET safe during pregnancy or breastfeeding?

ZIGLIM PLUS 1 TABLET is generally considered unsafe during pregnancy as it may harm the unborn baby. It is also probably unsafe during breastfeeding as it may pass into breast milk and affect the baby. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.

Can ZIGLIM PLUS 1 TABLET be taken with other medications?

ZIGLIM PLUS 1 TABLET can interact with various medications, affecting its efficacy or increasing the risk of side effects like hypoglycemia or lactic acidosis. Inform your doctor about all prescription, over-the-counter medicines, vitamins, and herbal supplements you are taking. Specific interactions can occur with other antidiabetic agents, non-steroidal anti-inflammatory agents (NSAIDs), antibiotics, antifungals, anticoagulants, and certain heart or blood pressure medications.

What precautions should be taken with ZIGLIM PLUS 1 TABLET?

• Regularly monitor your blood sugar levels as advised by your doctor.
• Inform your doctor if you have liver, kidney, or heart problems (especially heart failure), eye problems, hormonal imbalance, or if you are malnourished.
• Avoid alcohol consumption as it can increase the risk of low blood sugar and lactic acidosis.
• Do not drive or operate heavy machinery if your blood sugar is too low or too high, as it may affect your alertness.
• This medicine is not recommended for children.
• Long-term use may cause Vitamin B12 deficiency.

What happens if a dose of ZIGLIM PLUS 1 TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one, as this can lead to low blood sugar (hypoglycemia).

How should ZIGLIM PLUS 1 TABLET be stored?

Store ZIGLIM PLUS 1 TABLET in a cool and dry place, away from direct sunlight, moisture, and heat. Keep it in a closed container and out of the reach of children and pets. The storage temperature should generally be between 10ºC to 25ºC or below 30ºC.