Oxra L 10

OXRA L 10

Name:

• Brand Name: OXRA L 10
• Manufacturer: Sun Pharmaceutical Industries Ltd.

Composition:

• OXRA L 10 contains a fixed-dose combination of two active ingredients:
  • Dapagliflozin (10 mg)
  • Linagliptin (5 mg)

Uses: OXRA L 10 is an antidiabetic medicine primarily prescribed for the treatment of Type 2 Diabetes Mellitus in adults, used as an adjunct to diet and exercise to improve blood sugar control. Its uses also extend to:

• Cardiovascular and Kidney Protection: Helps reduce the risk of heart failure and kidney complications associated with diabetes by improving vascular function and lowering albumin levels in urine. It also protects kidneys from losing their function.
• Weight and Metabolic Control: May support weight loss and improve metabolic health by reducing glucose reabsorption and enhancing insulin sensitivity.

Dosage and Administration:

• Typically, take one tablet orally once daily, preferably in the morning.
• Can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not crush, chew, or split it.
• Take it at the same time each day to ensure consistent blood levels and to help with memory.
• Do not exceed the recommended dose. Do not stop taking it abruptly without consulting your doctor, as this may increase blood sugar levels and risk complications.

Side Effects: Common side effects may include:

• Urinary tract infections (UTIs)
• Nasopharyngitis (common cold-like symptoms)
• Diarrhea
• Headache
• Dizziness or light-headedness
• Hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines or alcohol
• Nausea and vomiting
• Cough
• Skin rash or itching
• Increased urination
• Genital yeast infection
• Fatigue
• Increased thirst

Precautions:

• Allergies: Do not take if you have a known allergy to dapagliflozin, linagliptin, or any other component of the tablet.
• Medical Conditions:
  • Inform your doctor if you have kidney or liver problems, heart disease, or a history of pancreatitis.
  • Not recommended for Type 1 Diabetes Mellitus or severe kidney or liver disease.
  • Use with caution in patients prone to ketoacidosis.
  • Maintain good personal hygiene to prevent genital infections.
• Pregnancy and Breastfeeding: Not recommended during the second and third trimesters of pregnancy due to potential fetal kidney injury, and generally not recommended during breastfeeding. Consult your doctor.
• Alcohol Consumption: Avoid excessive alcohol consumption as it can affect blood sugar levels and increase the risk of hypoglycemia and dehydration.
• Drug Interactions: Inform your healthcare provider about all other medications, supplements, and herbal products you are taking. Interactions can occur with diuretics, insulin and insulin secretagogues (increasing hypoglycemia risk), and certain antibiotics like rifampin, or antiepileptics such as carbamazepine, phenobarbital, or phenytoin.
• Driving and Operating Machinery: This medication may cause dizziness. Avoid driving or operating machinery until you know how it affects you. Always carry a source of fast-acting sugar (e.g., candy, fruit juice) in case of hypoglycemia.
• Children and Elderly: Not recommended for children or adolescents under 18 years of age. Elderly patients should use it under medical supervision, and dose adjustments may be required.
• Blood Sugar Monitoring: Regular monitoring of blood glucose levels is crucial while on this medication.

Storage:

• Store in a cool and dry place, protected from heat and moisture.
• Keep the medication in its original container, tightly closed, and out of sight and reach of children.
• Ideal storage temperature is between 15°C and 30°C (or below 30°C).

What is OXRA L 10 used for?

OXRA L 10 is an antidiabetic medicine primarily used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. Beyond glycemic control, it also offers cardiovascular and kidney protection, reducing the risk of heart failure and kidney complications associated with diabetes by improving vascular function and lowering albumin levels in urine. It can also help with weight and metabolic control.

How does OXRA L 10 work?

OXRA L 10 contains two active ingredients: Dapagliflozin (10mg) and Linagliptin (5mg). Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, works by blocking the reabsorption of glucose in the kidneys, leading to increased excretion of sugar through the urine. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the levels of natural substances called incretins, which help regulate blood sugar by stimulating insulin release, especially after meals, and decreasing the amount of sugar the liver produces.

What is the usual dosage of OXRA L 10?

The typical dosage for OXRA L 10 is one tablet once daily, taken with or without food, preferably in the morning. It's important to take it at the same time each day for consistent blood levels. Always follow your doctor's specific instructions regarding dosage and duration of treatment. Do not crush, chew, or split the tablet; swallow it whole with a glass of water.

What are the possible side effects of OXRA L 10?

Common side effects of OXRA L 10 may include urinary tract infections (UTIs), nasopharyngitis (cold-like symptoms), diarrhoea, cough, skin rash or itching, dizziness, headache, nausea, vomiting, frequent urination, and genital yeast infections. Some individuals may also experience hypoglycemia (low blood sugar), especially when taken with other antidiabetic medicines, alcohol, or if meals are delayed or missed.

Is OXRA L 10 safe during pregnancy or breastfeeding?

OXRA L 10 is generally not recommended during pregnancy, particularly in the second and third trimesters, due to potential risks of fetal kidney injury. Limited data is available regarding its effects during breastfeeding, and it is not recommended. It is crucial to consult your doctor if you are pregnant, planning pregnancy, or breastfeeding to discuss the risks and benefits.

Can OXRA L 10 be taken with other medications?

OXRA L 10 can interact with certain medications. Diuretics (water pills) like furosemide and hydrochlorothiazide can increase the risk of volume depletion. When taken with insulin or insulin secretagogues (medicines that stimulate insulin production, like glimepiride), the risk of hypoglycemia may increase, requiring dose adjustments. Certain antibiotics, such as rifampin, may reduce the efficacy of linagliptin. Always inform your healthcare provider about all medications, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using OXRA L 10?

Precautions to consider include:

• Kidney and Liver Disease: Use with caution if you have kidney or liver problems, as dose adjustments or alternative treatments may be necessary. It is not recommended for severe kidney or liver disease or Type 1 diabetes mellitus.
• Pancreatitis and Ketoacidosis: It should be avoided in patients with a history of pancreatitis, and caution is advised for patients prone to ketoacidosis.
• Alcohol: Avoid excessive alcohol consumption as it can affect blood sugar levels and increase the risk of hypoglycemia and dehydration.
• Driving and Machinery: OXRA L 10 may cause dizziness, so avoid driving or operating machinery until you know how it affects you.
• Hydration: Maintain adequate fluid intake to prevent dehydration, especially during situations like vomiting, diarrhoea, or excessive sweating.
• Hygiene: Practice good personal hygiene to help prevent genital and urinary tract infections, which can be side effects of the medication.

What happens if a dose of OXRA L 10 is missed?

If you miss a dose of OXRA L 10, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

How should OXRA L 10 be stored?

OXRA L 10 should be stored in a cool, dry place, protected from direct sunlight and moisture. Keep the medication in its original container, tightly closed, and out of the sight and reach of children. The ideal storage temperature is typically between 15°C and 30°C (59°F to 86°F).