Xylocaine 2% Jelly 50gm

XYLOCAINE 2% JELLY 50GM

Xylocaine 2% Jelly is a topical local anesthetic and lubricant manufactured by ZYDUS HEALTHCARE LIMITED.

• Name:

  • Brand Name: Xylocaine 2% Jelly
  • Common Name: Lidocaine Hydrochloride Jelly (also known as Lignocaine)

• Composition:

  • Each gram of jelly contains 20 mg of Lidocaine Hydrochloride (2% w/w).
  • Excipients may include hypromellose, methyl hydroxybenzoate, propyl hydroxybenzoate, sodium hydroxide, purified water, and hydrochloric acid.

• Uses: Xylocaine 2% Jelly is used to prevent and control pain and discomfort during various medical procedures and for symptomatic relief of certain conditions.

  • Surface anesthesia and lubrication for procedures involving the male and female urethra (e.g., cystoscopy, catheterization).
  • Anesthetic lubricant for endotracheal intubation and other endoscopic procedures (e.g., gastroscopy, bronchoscopy, proctoscopy, rectoscopy).
  • Pain relief and discomfort associated with skin irritation, minor burns, scratches, insect bites, and skin abrasions.
  • Treatment of painful urethritis and cystitis.
  • May also be used for post-herpetic neuralgia and premature ejaculation.

• Dosage and Administration: Xylocaine 2% Jelly is for external use only. Apply a thin layer to the affected area as directed by a healthcare provider.

  • Urethral Anesthesia (males): Typically 20 mL (400 mg lidocaine hydrochloride) may be required.
  • Endoscopy: 10-20 mL may be instilled, with a small amount for instrument lubrication.
  • Endotracheal Intubation: Approximately 2 mL applied to the tube surface just prior to insertion.
  • Maximum Dose: No more than 30 mL (600 mg) in a 12-hour period.
  • Children (under 12 years): Dose should not exceed 6 mg/kg.

• Side Effects:

  • Common/Mild: Application site reactions like burning sensation, itching, redness, irritation, skin rash, or drowsiness.
  • Serious (rare): Wheezing or difficulty breathing, chest pain, severe rash or itching, increased sweating, dizziness, confusion, numbness, blurred vision, vomiting, fits, unconsciousness, breathing problems, low blood pressure, slow heart rate, or collapse. Seek immediate medical attention if these occur.

• Precautions:

  • Contraindicated in patients with known hypersensitivity to amide-type local anesthetics or any formulation components.
  • Use with caution in patients with liver, kidney, or heart problems, epilepsy, impaired cardiac conduction, bradycardia, severe shock, sepsis, or traumatized mucosa.
  • Avoid application to large skin areas, broken, or infected skin unless directed by a doctor.
  • Do not eat or drink for at least one hour after oral or throat application to avoid biting trauma or aspiration.
  • Consult a doctor if pregnant or breastfeeding.

• Storage: Store in a cool, dry place below 25°C or 30°C, away from direct sunlight. Keep the medicine in its original pack and out of reach of children.

Here are the frequently asked questions regarding XYLOCAINE 2% JELLY 50GM by ZYDUS HEALTHCARE LIMITED:

What is Xylocaine 2% Jelly used for?

Xylocaine 2% Jelly is a local anesthetic and lubricant used to prevent pain and discomfort during various medical procedures. It is applied to mucous membranes of areas such as the male and female urethra for procedures like catheterization or cystoscopy, as well as nasal and pharyngeal cavities during endoscopic procedures like gastroscopy and bronchoscopy. It's also used during proctoscopy, rectoscopy, and for lubricating endotracheal tubes during intubation. Additionally, it can provide relief from pain, irritation, and itching associated with minor skin conditions, abrasions, insect bites, minor burns, and sunburn. It may also be used to treat post-herpetic neuralgia (pain after shingles) and urethritis (inflammation of the urethra), and in some cases, premature ejaculation.

How does Xylocaine 2% Jelly work?

Xylocaine 2% Jelly contains lidocaine (also known as lignocaine) as its active ingredient. Lidocaine works by stabilizing the neuronal membrane, which inhibits the ionic fluxes necessary for nerves to initiate and conduct electrical impulses. This action effectively blocks pain signals from reaching the brain, thereby producing a local anesthetic (numbing) effect in the applied area. The jelly also acts as a lubricant, reducing friction during the insertion of medical instruments. Anesthesia typically occurs rapidly, within 5 minutes, and lasts for approximately 20-30 minutes. It is ineffective when applied to intact skin.

What is the usual dosage of Xylocaine 2% Jelly?

The appropriate dosage of Xylocaine 2% Jelly varies depending on the application site, the patient's age, weight, and overall physical condition.

• For adult male urethral anesthesia: Typically 20 mL (400 mg lidocaine hydrochloride) is required. For catheterization, smaller volumes of 5-10 mL (100-200 mg) are often sufficient. The maximum recommended dose is 600 mg (30 mL) in any 12-hour period, and no more than four doses should be given within 24 hours.
• For adult female urethral anesthesia: 2-5 mL (60-100 mg) may be instilled.
• For endoscopy (e.g., gastroscopy, bronchoscopy, proctoscopy, rectoscopy): 10-20 mL may be instilled, with a small amount also used to lubricate the instrument.
• For endotracheal intubation: About 2 mL should be applied to the external surface of the tube just before insertion.
• For children under 12 years: The dose should not exceed 6 mg/kg of body weight (or 3 mL per 10 kg weight), and no more than four doses should be given in a 24-hour period. Always use the lowest dose that achieves effective anesthesia to prevent high plasma levels and potential serious side effects.

What are the possible side effects of Xylocaine 2% Jelly?

Most side effects are mild and temporary. Common side effects include application site reactions such as burning sensation, itching, redness, skin rash, or irritation. If used in the mouth or throat, a sore throat or drowsiness may occur. Serious side effects are rare and are generally associated with high plasma levels due to overdosage or rapid absorption. These may include wheezing or difficulty breathing, chest pain, severe rash or itching, increased sweating, dizziness, confusion, numbness (beyond the application site), blurred vision, vomiting, seizures (fits), unconsciousness, breathing problems, low blood pressure, slow heart rate, or collapse. Seek immediate medical attention if any serious side effects occur.

Is Xylocaine 2% Jelly safe during pregnancy or breastfeeding?

During Pregnancy: Xylocaine 2% Jelly is generally considered safe for use during pregnancy if prescribed by a doctor. While there are no adequate and well-controlled studies in pregnant women, extensive use has not shown an increased incidence of malformations, and animal studies indicate low or no adverse effects on the fetus. However, caution is advised, especially during early pregnancy when organogenesis occurs.

During Breastfeeding: Lidocaine and its metabolites are excreted in breast milk in small quantities. At therapeutic doses, the amount available to the infant is usually considered small and is not expected to pose a significant risk. Always consult your doctor before using Xylocaine 2% Jelly if you are pregnant or breastfeeding to discuss the risks and benefits.

Can Xylocaine 2% Jelly be taken with other medications?

While Xylocaine 2% Jelly is for external use and systemic interactions are less common, certain medications require caution:

• Local Anesthetics and Antiarrhythmics: Use with caution if you are taking other local anesthetics or structurally related drugs (e.g., mexiletine, tocainide) as their toxic effects can be additive. Similarly, caution is advised with Class I and Class III antiarrhythmic drugs (e.g., amiodarone) due to potential additive cardiac effects, and close surveillance may be recommended.
• Enzyme-Inducing Drugs: Drugs that reduce the clearance of lidocaine (such as cimetidine or beta-blockers) could potentially lead to toxic plasma concentrations if lidocaine is given in repeated high doses over a long period. However, for short-term topical treatment at recommended doses, such interactions are generally not expected to be clinically significant. Always inform your doctor or pharmacist about all other medicines you are using, including over-the-counter drugs and herbal supplements.

What precautions should be taken when using Xylocaine 2% Jelly?

• Do not apply the jelly to open wounds, broken skin, swollen areas, or deep puncture wounds unless specifically directed by a healthcare professional.
• Avoid contact with eyes, nose, or mouth. If accidental contact occurs, rinse the area thoroughly with water immediately.
• Strictly adhere to the prescribed dosage and administration guidelines, as excessive doses or short intervals between applications can lead to high plasma levels and serious adverse effects.
• Use with caution in children under 2 years of age, as safety and efficacy data are limited for this age group. Reduced doses may be necessary for children, elderly, debilitated, acutely ill, or septic patients.
• If applied in the mouth or throat, avoid eating or drinking for at least one hour afterward to prevent aspiration or unintentional biting trauma due to numbness.
• Be cautious when driving or operating machinery if you experience drowsiness or slow reflexes after using the jelly.
• Inform your doctor if you have any allergies, especially to amide-type local anesthetics or to parabens, which are preservatives found in some formulations.

What happens if a dose of Xylocaine 2% Jelly is missed?

If you miss an application of Xylocaine 2% Jelly, apply it as soon as you remember. Do not apply extra medicine to compensate for the missed dose, as over-applying can increase the risk of side effects.

How should Xylocaine 2% Jelly be stored?

Xylocaine 2% Jelly should be stored in its original packaging in a cool, dry place, away from direct sunlight. The storage temperature should be kept below 25°C or 30°C. Keep the medicine out of sight and reach of children. Avoid storing it in humid areas like the bathroom or near a sink, as heat and dampness can degrade the medicine. For single-use tubes, any unused portion should be discarded after initial use.