Dapamac Trio 500 Mg Tab

DAPAMAC TRIO 500 MG Tablet

Name:

• Brand Name: DAPAMAC TRIO 500 MG Tablet by MACLEODS - PROCARE MAX DIVISION
• Common Name: Dapamac Trio Tablet

Composition: Each tablet contains a combination of three active ingredients:

• Dapagliflozin: 10 mg
• Metformin: 500 mg
• Sitagliptin: 100 mg

Uses: DAPAMAC TRIO 500 MG Tablet is an antidiabetic medicine primarily prescribed for the management of Type 2 Diabetes Mellitus in adults, used as an adjunct to diet and exercise. It works to improve blood sugar control by removing excess sugar from the body via urine, increasing natural substances that lower blood sugar, and reducing sugar production by the liver. Additionally, it helps lower the risk of heart failure and diabetic kidney disease, supports weight loss, and improves overall metabolic health.

Dosage and Administration: Take DAPAMAC TRIO 500 MG Tablet as advised by your doctor. It can be taken with or without food, but it is often recommended to take it with meals to minimize stomach upset. Swallow the tablet whole with a glass of water; do not crush, break, or chew it. For best results, try to take it at the same time each day. The dosage and duration will be determined by your physician based on your condition.

Side Effects: Common Side Effects include:

• Nausea, vomiting, abdominal pain, stomach upset, headache
• Hypoglycemia (low blood glucose level)
• Flatulence, diarrhea, constipation
• Genital infections, urinary tract infection, increased or more frequent urination
• Drowsiness, dizziness
• Nasal congestion, sore throat, upper respiratory tract infection
• Dry mouth, decreased weight, thirst

Serious Side Effects (rare but require immediate medical attention) include:

• Signs of lactic acidosis (weakness, difficulty breathing, severe stomach pain)
• Symptoms of ketoacidosis (nausea, vomiting, confusion, fruity breath)
• Severe or persistent genital or urinary infections
• Signs of pancreatitis (severe stomach pain or nausea)
• Allergic reactions (rash, swelling, breathing problems)

Precautions:

• Inform your doctor about your complete medical history, especially if you have kidney or liver problems, heart failure, respiratory failure, a recent myocardial infarction, or a urinary tract infection.
• It is not recommended for individuals with severe liver or kidney disease, metabolic acidosis, or diabetic ketoacidosis.
• Avoid excessive alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as it is generally not recommended during these periods.
• Not recommended for use in children below 18 years of age.
• Regular monitoring of blood sugar levels and kidney function is advised during treatment.
• Disclose all medications, including herbal supplements and over-the-counter drugs, to your doctor to avoid potential drug interactions (e.g., with insulin, sulfonylureas, diuretics, certain antifungals, antivirals, or corticosteroids). Avoid grapefruit and grapefruit juice.

Storage: Store DAPAMAC TRIO 500 MG Tablet in a cool, dry place away from direct sunlight. Keep it at temperatures between 10ºC to 25ºC or below 30ºC. Keep this medicine out of the sight and reach of children.

DAPAMAC TRIO 500 MG Tablet, manufactured by Macleods Pharmaceuticals Ltd., is a combination medication used to manage Type 2 Diabetes Mellitus. It contains three active ingredients: Dapagliflozin, Metformin, and Sitagliptin.

Here are some frequently asked questions about DAPAMAC TRIO 500 MG Tablet:

What is DAPAMAC TRIO 500 MG Tablet used for?

DAPAMAC TRIO 500 MG Tablet is primarily used to treat Type 2 Diabetes Mellitus in adults. It is prescribed when diet, exercise, and therapy with other conventional medicines do not adequately control blood sugar levels. This medicine helps to improve blood sugar control, reduce insulin resistance, and promote glucose excretion. It may also aid in weight management and reduce cardiovascular risk.

How does DAPAMAC TRIO 500 MG Tablet work?

DAPAMAC TRIO 500 MG Tablet works through the combined action of its three active ingredients:

• Dapagliflozin: This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by reducing the reabsorption of glucose in the kidneys, leading to increased excretion of excess sugar through the urine, thereby lowering blood glucose levels.
• Metformin: A biguanide, Metformin reduces the amount of glucose produced by the liver and delays glucose absorption from the intestines. It also improves the body's sensitivity to insulin, allowing for better glucose uptake by muscles and tissues.
• Sitagliptin: This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of certain natural substances (incretin hormones) in the body that help the pancreas release more insulin and decrease glucagon levels when blood sugar is high. The combined effect provides multi-targeted control of blood sugar levels.

What is the usual dosage of DAPAMAC TRIO 500 MG Tablet?

The dosage of DAPAMAC TRIO 500 MG Tablet is determined by your doctor based on your specific condition, response to treatment, age, and body weight. It should be taken as advised by your physician, usually swallowed whole with a glass of water. It can be taken with or without food, but taking it with meals may help reduce stomach upset. It is important to take it at the same time each day and not to crush, break, or chew the tablet. Do not stop taking this medicine without consulting your doctor.

What are the possible side effects of DAPAMAC TRIO 500 MG Tablet?

Common side effects may include:

• Nausea, vomiting, and abdominal pain/upset
• Headache
• Diarrhea or flatulence
• Genital infections and urinary tract infections
• Common cold, sore throat, and upper respiratory tract infection
• Hypoglycemia (low blood sugar level), especially when taken with other antidiabetic medicines, alcohol, or if a meal is delayed/skipped.

Most of these side effects are temporary and usually resolve over time. However, if any side effects persist or worsen, or if you experience serious side effects like lactic acidosis, ketoacidosis, severe abdominal pain (signs of pancreatitis), or allergic reactions, you should consult your doctor immediately.

Is DAPAMAC TRIO 500 MG Tablet safe during pregnancy or breastfeeding?

DAPAMAC TRIO 500 MG Tablet is generally not recommended for use during pregnancy or while breastfeeding. It is important to inform your doctor if you are pregnant, planning pregnancy, or breastfeeding, so they can assess the risks and benefits and recommend a suitable alternative if necessary.

Can DAPAMAC TRIO 500 MG Tablet be taken with other medications?

DAPAMAC TRIO 500 MG Tablet can interact with certain medications. It is crucial to inform your doctor about all prescription, non-prescription, herbal supplements, and other medicines you are taking. Notable interactions include:

• Diuretics (water pills): These can increase the risk of volume depletion due to Dapagliflozin's action.
• Insulin and Insulin Secretagogues (e.g., glimepiride): When taken with DAPAMAC TRIO 500 MG Tablet, these can increase the risk of hypoglycemia, and dose adjustment may be necessary.
• Corticosteroids: These medicines, used for pain and inflammatory conditions, may interact.
• Beta-blockers: A type of heart medicine that may mask the symptoms of hypoglycemia.
• Iodinated contrast agents: Metformin should be stopped before or at the time of an iodinated contrast imaging procedure and withheld for at least 48 hours afterward, then reinitiated only after renal function has been re-evaluated and found to be normal.

What precautions should be taken while using DAPAMAC TRIO 500 MG Tablet?

• Kidney and Liver Health: Use with caution if you have kidney or liver problems. It is not recommended for patients with severe liver or kidney disease.
• Alcohol Consumption: Avoid excessive alcohol intake as it increases the risk of hypoglycemia and lactic acidosis.
• Hydration: Drink plenty of fluids to help prevent dehydration.
• Hygiene: Maintain good genital hygiene to help prevent fungal infections.
• Medical History: Inform your doctor about your complete medical history, including any urinary tract infections, heart failure, or recent myocardial infarction.
• Monitoring: Your doctor will regularly monitor your blood sugar levels and kidney function.
• Diet and Exercise: This medication is part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DAPAMAC TRIO 500 MG Tablet be stored?

Store DAPAMAC TRIO 500 MG Tablet in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. It should generally be stored below 30°C. Do not use the medicine past its expiry date.