Pregabid Od 100 Mg Tab

PREGABID OD 100 MG TABLET

PREGABID OD 100 MG TABLET, manufactured by INTAS PHARMACEUTICALS LTD, is an extended-release medication containing Pregabalin, an anticonvulsant and analgesic agent. The "OD" in its name signifies its "Once Daily" formulation, designed to provide a sustained release of the medication.

Composition

Each tablet contains 100 mg of Pregabalin in an extended-release (OD) formulation. Pregabalin works by binding to a specific subunit of voltage-gated calcium channels in the central nervous system, which modulates the release of neurotransmitters involved in pain signaling and seizure activity.

Uses

PREGABID OD 100 MG TABLET is primarily prescribed for the management of:

• Neuropathic Pain: Including diabetic neuropathy, postherpetic neuralgia (nerve pain following shingles), and spinal cord injury-related pain.
• Fibromyalgia: A chronic condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances.
• Epilepsy: As an adjunctive therapy for adults with partial seizures.
• Generalized Anxiety Disorder (GAD): To alleviate symptoms of severe anxiety.

Dosage and Administration

PREGABID OD 100 MG TABLET is intended for once-daily oral administration. The tablet should be swallowed whole and not crushed, chewed, or broken. It can be taken with or without food, though some sources suggest taking extended-release formulations after an evening meal. The dosage is individualized by a doctor, typically starting low and gradually increasing based on the patient's condition and response. Do not stop taking this medication abruptly, as it can lead to withdrawal symptoms; the dosage should be tapered gradually under medical supervision.

Side Effects

Common side effects may include:

• Dizziness, drowsiness, headache
• Blurred vision, dry mouth, increased appetite
• Edema (swelling, particularly in the limbs)
• Weight gain, difficulty with concentration or attention
• Constipation, vomiting, flatulence, diarrhea
• Muscle cramps, joint or back pain, tiredness, tingling or numbness, difficulty sleeping, tremor, difficulty speaking

Serious side effects that require immediate medical attention include severe skin reactions (like Stevens-Johnson syndrome), yellow discoloration of the skin or eyes, suicidal thoughts or behavior, or swelling (angioedema) which could affect breathing.

Precautions

• Alcohol: Avoid consuming alcohol while taking PREGABID OD 100 MG TABLET, as it can intensify dizziness and drowsiness.
• Driving and Operating Machinery: Due to potential dizziness and drowsiness, avoid driving or operating heavy machinery until you understand how the medication affects you.
• Pregnancy and Breastfeeding: This medicine is generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor. Women of childbearing age should use effective contraception during treatment.
• Medical Conditions: Inform your doctor about any pre-existing medical conditions, especially kidney problems, heart conditions, diabetes, liver disease, or a history of substance abuse.
• Drug Interactions: Before starting, inform your doctor about all other medications, supplements, and herbal remedies you are taking, particularly strong opioids, benzodiazepines, certain antidiabetic agents (thiazolidinediones), ACE inhibitors, antihistamines, sedatives, or other CNS depressants, as interactions can occur.
• Elderly Patients: Use with caution in patients over 65 years, especially those with kidney impairment.
• Pediatric Use: The safety and effectiveness in children under 18 years of age have not been established.

Storage

Store PREGABID OD 100 MG TABLET in a cool, dry place, protected from direct sunlight and moisture, at a temperature below 25°C or 30°C. Keep it out of sight and reach of children and pets.

PREGABID OD 100 MG Tablet, containing pregabalin, is an extended-release medication primarily used to manage various types of nerve pain and certain seizure disorders. Its "OD" designation means it is designed for once-daily administration.

What is PREGABID OD 100 MG Tablet used for?

PREGABID OD 100 MG Tablet is mainly used to treat neuropathic pain, which includes pain caused by diabetic neuropathy (nerve damage from diabetes), postherpetic neuralgia (nerve pain after shingles), and spinal cord injury-related pain. It is also prescribed for fibromyalgia and as an add-on therapy for partial seizures (fits) in adults. In some cases, it may also be used to manage generalized anxiety disorder.

How does PREGABID OD 100 MG Tablet work?

The active ingredient, pregabalin, works by binding to a specific part (the alpha-2-delta subunit) of voltage-gated calcium channels in the central nervous system. This action reduces the release of certain excitatory neurotransmitters, such as glutamate, norepinephrine, and substance P, which are involved in transmitting pain signals and contributing to nerve overactivity. By calming these overactive nerves, pregabalin helps to alleviate pain and control seizures.

What is the usual dosage for PREGABID OD 100 MG Tablet?

PREGABID OD 100 MG is an extended-release formulation designed for once-daily use. The exact dosage depends on the condition being treated and individual response. For neuropathic pain, an initial dose might be 75 mg twice daily or 150 mg once daily. For epilepsy, it often starts at 150 mg per day as a single dose. For generalized anxiety disorder, the initial dose is commonly 150 mg per day, with the possibility of increasing up to a maximum of 600 mg daily. It is crucial to follow your doctor's specific instructions, and the tablet should be swallowed whole, typically after an evening meal.

What are the possible side effects of PREGABID OD 100 MG Tablet?

Common side effects can include dizziness, drowsiness (somnolence), blurred vision, dry mouth, swelling (edema) in the hands or feet, weight gain, headache, and increased appetite. Other possible side effects include difficulty concentrating, memory impairment, tremor, difficulty speaking, tingling or numbness, lethargy, difficulty sleeping, tiredness, muscle cramps, joint or back pain, and constipation. More serious but rare side effects can include severe allergic reactions (angioedema), thoughts of self-harm or suicide, and breathing problems, especially when taken with other central nervous system depressants.

Is PREGABID OD 100 MG Tablet safe during pregnancy or breastfeeding?

Pregnancy: PREGABID OD 100 MG Tablet is generally not recommended during pregnancy unless your doctor determines that the potential benefits outweigh the risks. Women of childbearing age should use effective contraception while taking this medicine. If you are pregnant or planning to become pregnant, consult your doctor immediately. If prescribed during pregnancy, high-dose folic acid (5mg daily) may be recommended.

Breastfeeding: Pregabalin passes into breast milk in small amounts. It is generally not recommended for breastfeeding mothers unless specifically advised by a doctor. If you are breastfeeding while taking this medication, your infant should be monitored for potential side effects such as drowsiness, dry mouth, changes in feeding patterns, or slowed breathing. An alternative medication might be suggested, especially for newborns or preterm infants.

Can PREGABID OD 100 MG Tablet be taken with other medications?

Taking PREGABID OD 100 MG Tablet with certain other medications can lead to interactions. It's particularly important to avoid or use caution with:

• Central Nervous System (CNS) Depressants: These include opioids, benzodiazepines, other sedatives, certain antihistamines, and alcohol. Combining them with pregabalin can significantly increase drowsiness, dizziness, and the risk of severe breathing problems.
• ACE Inhibitors: Medications for high blood pressure (like captopril, enalapril, lisinopril) may increase the risk of a severe allergic reaction called angioedema when taken with pregabalin.
• Certain Antidiabetic Agents: Drugs like thiazolidinediones (e.g., pioglitazone, rosiglitazone) when combined with pregabalin, may increase the risk of weight gain, fluid retention, and potentially heart failure.

Always inform your doctor about all medications, supplements, and herbal remedies you are currently taking to avoid potential interactions.

What precautions should be taken while taking PREGABID OD 100 MG Tablet?

• Drowsiness and Dizziness: This medicine can cause drowsiness, dizziness, and blurred vision. Avoid driving, operating heavy machinery, or performing tasks that require alertness until you know how it affects you.
• Alcohol: Avoid consuming alcohol as it can worsen side effects like dizziness and drowsiness.
• Pre-existing Conditions: Inform your doctor if you have kidney problems, heart conditions (like congestive heart failure), diabetes, liver disease, lung problems, or a history of drug or alcohol abuse. Your dosage may need adjustment, or specific monitoring might be required.
• Do Not Stop Abruptly: Do not stop taking PREGABID OD 100 MG Tablet suddenly without consulting your doctor, even if you feel better. Abrupt discontinuation can lead to withdrawal symptoms or trigger seizures, especially in individuals with epilepsy.

What happens if a dose of PREGABID OD 100 MG Tablet is missed?

If you miss a dose of PREGABID OD 100 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose (e.g., within 2 hours), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss the extended-release tablet after your evening meal, you can take it before bedtime after a snack. If you miss the dose before bedtime, take it after your morning meal the next day. If that is also missed, then take the next dose at your regular time after your evening meal. Missing doses regularly, particularly if you have epilepsy, can potentially trigger a seizure.

How should PREGABID OD 100 MG Tablet be stored?

Store PREGABID OD 100 MG Tablet in a cool, dry place, protected from direct sunlight and moisture. Keep it in its tightly closed original container and out of the reach of children and pets. Do not store it in the bathroom. Ensure the medication remains effective and safe until its expiration date.