Pramirol Sr 1.05 Mg Tablet (10 Tab)

PRAMIROL SR 1.05 MG TABLET (10 TAB) by INTAS PHARMACEUTICALS LTD.

Pramirol SR 1.05 MG Tablet is a medication used to manage the symptoms of Parkinson's disease and Restless Legs Syndrome. It is manufactured by Intas Pharmaceuticals Ltd..

• Name

  • Brand Names: Pramirol SR 1.05 Tablet, Pramirol SR 1.05MG Tablet.
  • Common Name (Active Ingredient): Pramipexole.

• Composition

  • Each sustained-release (SR) tablet contains Pramipexole 1.05 mg.

• Uses Pramirol SR 1.05 Tablet is primarily prescribed for the treatment of:

  • Parkinson's Disease: It helps in alleviating symptoms such as tremors, muscle stiffness, and difficulty with movement by stimulating dopamine receptors in the brain.
  • Restless Legs Syndrome (Willis-Ekbom Disease): It provides relief from the uncomfortable urge to move the legs, especially during the evening or nighttime, leading to improved sleep quality.

• Dosage and Administration

  • Take Pramirol SR 1.05 Tablet as directed by your doctor.
  • It can be taken with or without food; taking it with food may help reduce nausea.
  • Swallow the tablet whole with water; do not crush, break, or chew it.
  • Maintain a consistent dosing schedule by taking the medicine at the same time each day.
  • For Restless Legs Syndrome, it is typically recommended to take the tablet 2-3 hours before bedtime.
  • Do not discontinue the medication abruptly without consulting your healthcare provider.

• Side Effects

  • Common Side Effects: Nausea, dry mouth, fatigue, hallucinations, constipation, peripheral edema (swelling in extremities), dizziness, and sleepiness.
  • Serious Side Effects: Unusual mood changes, increased sex drive, gambling urges, compulsive spending habits, confusion, aggressive behavior, agitation, abnormal thoughts, changes in vision, uncontrollable body movements, and involuntary postures (e.g., neck bending forward). Other serious effects include dark-colored urine, muscle tenderness, stiffness, aching, or weakness, and orthostatic hypotension (sudden drop in blood pressure upon standing).

• Precautions

  • Contraindications: Not recommended for individuals with kidney diseases or psychosis.
  • Pregnancy and Breastfeeding: Use is not recommended during pregnancy or breastfeeding as it may be unsafe.
  • Children: Not recommended for individuals under 18 years of age.
  • Alcohol: Avoid alcohol consumption as it can increase drowsiness and dizziness.
  • Driving and Operating Machinery: Due to potential dizziness, sleepiness, and hallucinations, avoid activities requiring mental alertness until you know how the medication affects you.
  • Orthostatic Hypotension: Rise slowly from sitting or lying positions to minimize the risk of dizziness or fainting.
  • Interactions: Inform your doctor about all other medications you are taking, including cimetidine, ranitidine, antacids, amantadine, levodopa, benztropine, mexiletine, procainamide, quinidine, zidovudine, cisplatin, quinine, and sedatives.
  • Other Conditions: Use with caution in patients with liver impairment, dyskinesia, dystonia, severe heart or blood vessel disease, or augmentation. Report any unusual mood changes or compulsive behaviors to your doctor.

• Storage

  • Store Pramirol SR 1.05 Tablet in a cool and dry place, protected from direct sunlight, moisture, and heat. Store below 30°C.
  • Keep out of reach and sight of children and pets.

Pramirol SR 1.05 MG Tablet is a medication primarily used to manage symptoms of Parkinson's disease and Restless Legs Syndrome. It contains pramipexole as its active ingredient.

Here are some frequently asked questions about Pramirol SR 1.05 MG Tablet:

What is Pramirol SR 1.05 MG Tablet used for?

Pramirol SR 1.05 MG Tablet is used to treat the signs and symptoms of idiopathic Parkinson's disease, a progressive neurological condition affecting movement. It is also prescribed for moderate to severe restless legs syndrome (RLS), also known as Willis-Ekbom disease, which causes an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations.

How does Pramirol SR 1.05 MG Tablet work?

Pramirol SR 1.05 MG Tablet works by mimicking the action of dopamine, a natural chemical messenger in the brain that is essential for controlling body movements. By stimulating dopamine receptors in the brain, it triggers nerve impulses that help in controlling body movements, thereby alleviating symptoms associated with Parkinson's disease and Restless Legs Syndrome.

What is the usual dosage of Pramirol SR 1.05 MG Tablet?

Pramirol SR 1.05 MG Tablet is an extended-release formulation, typically taken once daily. For Parkinson's disease, adults may start with 0.375 mg once a day, with the dose adjusted by the doctor, usually not exceeding 4.5 mg per day. For restless legs syndrome, an initial dose is often 0.125 mg once daily, taken 2-3 hours before bedtime. It should be swallowed whole with a glass of water and not cut, broken, or chewed. It can be taken with or without food, though taking it with food may help reduce nausea. Always follow your doctor's specific instructions for dosage and duration.

What are the possible side effects of Pramirol SR 1.05 MG Tablet?

Common side effects can include nausea, dry mouth, fatigue, dizziness, sleepiness, constipation, headache, and swelling in the lower legs or hands (peripheral edema). More serious side effects can include hallucinations (seeing or hearing things that are not real), confusion, abnormal uncontrolled movements (dyskinesia), agitation, aggressive behavior, abnormal thoughts, and changes in vision. It may also cause impulse control disorders, such as increased urges to gamble, binge eat, or engage in sexual behaviors.

Is it safe during pregnancy or breastfeeding?

Pramirol SR 1.05 MG Tablet is generally not recommended during pregnancy due to limited information on its safety in human pregnancy and potential harmful effects observed in animal studies. If you are pregnant, planning a pregnancy, or think you might be pregnant, you should consult your doctor. It is also considered unsafe during breastfeeding as it can reduce breast milk production and it is unknown if pramipexole passes into breast milk. Therefore, breastfeeding is generally not advised while taking this medicine.

Can it be taken with other medications?

Pramirol SR 1.05 MG Tablet can interact with other medications. You should be cautious if taking sedatives. If you are also taking levodopa for Parkinson's disease, your doctor may reduce the levodopa dose when starting Pramirol SR. Other medicines that may interact include cimetidine (for stomach ulcers), amantadine (for Parkinson's disease), mexiletine, procainamide (for heart problems), zidovudine (for HIV), cisplatin (for cancer), and quinine (for malaria). It is important to inform your doctor about all medicines, supplements, or herbal preparations you are currently taking or plan to take.

What precautions should be taken?

Several precautions should be taken:

• Sudden Sleepiness and Dizziness: This medicine can cause sudden sleepiness or dizziness, which may impair your ability to drive or operate heavy machinery. Avoid these activities until you know how the medication affects you.
• Orthostatic Hypotension: Pramirol SR can cause a sudden drop in blood pressure when changing positions (e.g., standing up quickly), leading to dizziness or fainting. Rise slowly from a sitting or lying position.
• Impulse Control Disorders: Inform your doctor if you experience new or increased urges to gamble, binge eat, spend money, or have increased sexual urges.
• Kidney Disease: Use with caution in patients with kidney problems, as the effects may be increased due to slower removal of the medicine from the body.
• Psychiatric Disorders: Use with caution in patients with a history of psychiatric disorders.
• Alcohol Consumption: Avoid consuming alcohol as it can increase drowsiness and dizziness.
• Age Restriction: Pramirol SR 1.05 MG Tablet is not recommended for use in patients less than 18 years of age.

What happens if a dose is missed?

If you miss a dose of Pramirol SR 1.05 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Pramirol SR 1.05 MG Tablet should be stored in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it away from children and pets.