Nexovas Ch Tablet (10 Tab)

NEXOVAS CH TABLET is a medication manufactured by MACLEODS PHARMACEUTICALS LTD., primarily used for managing high blood pressure.

Name

• Brand Name: Nexovas CH Tablet
• Common Name: Cilnidipine & Chlorthalidone Tablets

Composition

NEXOVAS CH TABLET contains two active ingredients:

• Cilnidipine (10 mg)
• Chlorthalidone (12.5 mg)

Uses

This combination medicine is primarily prescribed for the management of hypertension (high blood pressure). It helps to lower blood pressure, thereby reducing the risk of cardiovascular events such as heart attack, stroke, and kidney damage. It may also be used as an initial therapy for patients likely to need multiple medicines to control their blood pressure or as a substitute for individual components (Cilnidipine and Chlorthalidone) if already being taken separately.

Dosage and Administration

NEXOVAS CH TABLET should be taken orally as directed by a doctor. It is typically advised to take it with food, preferably in the morning, to avoid frequent urination at night. The tablet should be swallowed whole and not chewed, crushed, or broken. The dosage may vary based on individual response and condition severity, and it should not be exceeded without consulting a doctor.

Side Effects

Common Side Effects:

• Headache
• Dizziness, lightheadedness
• Fatigue, tiredness, sleepiness
• Nausea, stomach pain
• Frequent urination (polyuria)
• Muscle spasms, muscle weakness
• Low potassium levels (hypokalemia)
• Increased uric acid levels (hyperuricemia)
• Ankle swelling (peripheral oedema)
• Flushing (skin reddening)

Serious Side Effects (Seek immediate medical attention if experienced):

• Chest pain
• Severe dizziness or fainting
• Very low blood pressure
• Worsening heart failure
• Jaundice (yellowing of skin or eyes)
• Allergic swelling
• Kidney failure
• Severe electrolyte imbalance

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy and breastfeeding unless prescribed by a doctor.
• Alcohol: Avoid alcohol consumption as it may enhance blood pressure-lowering effects and increase drowsiness.
• Driving and Operating Machinery: May cause dizziness or sleepiness; avoid activities requiring concentration until effects are known.
• Medical Conditions: Use with caution in patients with liver or kidney disease, heart problems, diabetes, gout, or electrolyte imbalances. It is contraindicated in severe kidney/liver disease, blocked bile ducts, very low potassium/sodium levels, gout, or untreated Addison's disease.
• Drug Interactions: Inform your doctor about all other medications, including NSAIDs, lithium-based medications, digoxin, other antihypertensives, and certain antifungal medicines, as interactions can occur.
• Diet: Avoid grapefruit juice as it may increase medicine levels. High potassium foods should be consumed cautiously as chlorthalidone can cause low potassium levels.

Storage

Store NEXOVAS CH TABLET at a normal room temperature, typically between 20°C to 25°C, and below 30°C. Protect the medicine from excessive heat and moisture, ensuring it is kept in a dry place and out of reach of children. Ensure the medicine is used before its expiry date.

Here are some frequently asked questions about NEXOVAS CH TABLET:

What is NEXOVAS CH TABLET used for?

NEXOVAS CH TABLET is primarily used to manage high blood pressure, also known as hypertension, in adults. It can also be used as an initial therapy for patients likely to need multiple medications to control their blood pressure or as a substitute for its individual components (Cilnidipine and Chlorthalidone) if already being taken. By lowering blood pressure, it helps reduce the risk of serious complications such as heart attack, stroke, and kidney problems.

How does NEXOVAS CH TABLET work?

NEXOVAS CH TABLET contains two active ingredients: Cilnidipine and Chlorthalidone.

• Cilnidipine (10 mg) is a calcium channel blocker that works by relaxing the muscles of your heart and blood vessels. This action widens the blood vessels, which lowers the pressure exerted by the blood and decreases the workload on the heart.
• Chlorthalidone (12.5 mg) is a diuretic, also known as a "water pill." It helps your kidneys remove excess salt and water from your body through urine, thereby reducing the fluid in your blood vessels and lowering blood pressure.

What is the usual dosage of NEXOVAS CH TABLET?

The dosage of NEXOVAS CH TABLET is prescribed by your doctor and may vary depending on individual factors, such as your response to treatment and the severity of your condition. It should be taken orally as directed by your doctor, preferably with food in the morning to avoid frequent urination at night. Do not chew, crush, or break the tablet, and always stick to the prescribed dosage without exceeding it.

What are the possible side effects of NEXOVAS CH TABLET?

Common side effects of NEXOVAS CH TABLET can include headache, dizziness, fatigue, nausea, and frequent urination. Other reported side effects include muscle spasms, low potassium levels (hypokalemia), increased uric acid levels (hyperuricemia), ankle swelling, flushing, palpitations, and lethargy. If these symptoms persist or worsen, or if you experience serious side effects like severe dizziness, very low blood pressure, worsening heart failure, or jaundice, consult your doctor immediately.

Is NEXOVAS CH TABLET safe during pregnancy or breastfeeding?

NEXOVAS CH TABLET should be used with caution during pregnancy, and it is best to consult your doctor. Chlorthalidone, one of its components, may cause jaundice, low blood sugar, and bruising in newborn babies. Similarly, it is not recommended for use in breastfeeding women as it may suppress lactation and be excreted in breast milk, potentially passing to the baby. Always consult your doctor for advice before taking this medicine if you are pregnant or breastfeeding.

Can NEXOVAS CH TABLET be taken with other medications?

NEXOVAS CH TABLET can interact with certain medications.

• Lithium-based medications: Chlorthalidone can increase lithium levels in your body.
• NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) like ibuprofen and naproxen: These can reduce the blood pressure-lowering effect of NEXOVAS CH TABLET.
• Heart medications like digoxin: Chlorthalidone-induced electrolyte imbalances can enhance digoxin toxicity.
• CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): These may increase the levels of cilnidipine in your body. It is important to inform your doctor about all other medicines, herbal preparations, and supplements you are currently taking to avoid potential interactions.

What precautions should be taken while using NEXOVAS CH TABLET?

Several precautions should be considered:

• Alcohol: Avoid alcohol consumption as it may enhance the blood pressure-lowering effect and aggravate side effects.
• Driving and Operating Machinery: This medicine may cause dizziness or sleepiness, so avoid activities requiring concentration, like driving or operating machinery, until you know how it affects you.
• Kidney and Liver Disease: Use with caution in patients with liver or kidney disease. It is generally not recommended for those with severe kidney or liver failure.
• Electrolyte Imbalance: Chlorthalidone can cause changes in electrolyte balance (e.g., low potassium, sodium, or magnesium, and raised calcium or uric acid). Your doctor may monitor your electrolyte levels regularly.
• Gout: If you have gout, chlorthalidone could increase uric acid levels.
• Older Patients: Elderly patients (above 70 years) may be more susceptible to side effects and should take this medicine under medical supervision.
• Diet: Consume high potassium foods cautiously as chlorthalidone can cause low potassium levels. Also, avoid grapefruit or grapefruit juice as it can interfere with the medication.

What happens if a dose of NEXOVAS CH TABLET is missed?

If you forget to take your regular dose of NEXOVAS CH TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not double your dose to make up for the missed one.

How should NEXOVAS CH TABLET be stored?

Keep NEXOVAS CH TABLET stored at a normal room temperature, typically between 20°C to 25°C. Protect the medicine from excessive heat and moisture, ensuring it's kept in a dry place. As with all medicines, keep it out of reach of children. Ensure you use your medicine before its expiry date.