Macsita M Xr 50/500 Mg Tablet (10 Tab)

MACSITA M XR 50/500 MG TABLET

MACSITA M XR 50/500 MG TABLET is an antidiabetic medication manufactured by Macleods Pharmaceuticals Ltd., used for the management of Type 2 Diabetes Mellitus. The "XR" denotes an extended-release formulation.

• Composition Each extended-release tablet contains Sitagliptin 50 mg and Metformin 500 mg.

• Uses MACSITA M XR is prescribed to help control high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is used as an adjunct to diet and exercise to improve glycemic control. By regulating blood sugar, this medication helps prevent serious complications of diabetes, such as kidney damage, vision problems, nerve damage, heart ailments, and stroke.

• Dosage and Administration This medication should be taken preferably after meals to mitigate digestive discomfort. Tablets should be swallowed whole and not crushed or chewed. The appropriate dosage and duration of therapy are determined by a healthcare professional based on the patient's health condition, blood sugar levels, and concomitant medications. Consistent and timely intake is crucial for optimal benefits.

• Side Effects

  • Common Side Effects: Decreased appetite, nausea, vomiting, diarrhea, upset stomach, flatulence, headache, sore throat, upper respiratory tract infections, abdominal bloating, metallic taste, swelling in the hands and legs (edema), drowsiness, dizziness, dry mouth, and joint or limb pain. Low blood sugar levels (hypoglycemia) can occur, especially when combined with other antidiabetic medications.
  • Serious Side Effects: Seek immediate medical attention if experiencing symptoms of acute pancreatitis, severe kidney problems, or lactic acidosis (e.g., muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, difficulty breathing, persistent nausea, vomiting, stomach pain, or a slow heart rate). Severe allergic reactions like hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing also require urgent medical care.

• Precautions Before taking MACSITA M XR, inform your doctor about any allergies to sitagliptin, metformin, or other components. This medicine is not recommended for patients with severe kidney impairment, severe heart problems (e.g., acute heart failure, recent heart attack), lactic acidosis, diabetic ketoacidosis, or Type 1 diabetes mellitus. It is also contraindicated in severe, uncontrollable diabetes, alcoholism, shock, and breathing or blood circulation problems. Pregnant or breastfeeding women should consult their healthcare provider before use. Caution is advised for patients with liver problems, high blood cholesterol levels, severe systemic infections, or those who are severely dehydrated. Inform your doctor if you have a history of pancreatitis, high blood lipids, upcoming major surgery, fasting, malnutrition, extreme exercise, or vitamin B12 deficiency. Regular monitoring of blood sugar levels and kidney function is recommended during treatment. Alcohol consumption should be limited or avoided due to an increased risk of lactic acidosis and lowered blood glucose.

• Storage Store the medicine in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children.

What is MACSITA M XR 50/500 MG TABLET used for?

MACSITA M XR 50/500 MG TABLET is an antidiabetic medicine primarily used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed as an adjunct to a proper diet and regular exercise. This medication helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve damage, and may reduce the risk of heart attack or stroke.

How does MACSITA M XR 50/500 MG TABLET work?

This tablet contains two active ingredients: Sitagliptin (50 mg) and Metformin (500 mg, extended-release). Sitagliptin works by increasing the levels of certain natural substances (incretin hormones like GLP-1 and GIP) in the body, which then stimulate the pancreas to release more insulin after meals and decrease the amount of sugar produced by the liver. Metformin primarily reduces the production of glucose by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, allowing cells to utilize more circulating blood glucose. Together, these actions help to regulate blood sugar levels.

What is the usual dosage of MACSITA M XR 50/500 MG TABLET?

MACSITA M XR is an extended-release tablet and is typically taken once daily with a meal, preferably in the evening, to minimize gastrointestinal side effects. The dosage is individualized by your doctor based on your current regimen, effectiveness, and tolerability. For patients not currently taking metformin, a common starting dose might be 100 mg sitagliptin and 1000 mg metformin once daily, with gradual escalation. The maximum recommended daily dose is generally 100 mg of sitagliptin and 2000 mg of extended-release metformin. Tablets should be swallowed whole and not split, crushed, or chewed.

What are the possible side effects of MACSITA M XR 50/500 MG TABLET?

Common side effects include low blood sugar (hypoglycemia), especially when taken with other diabetes medicines, diarrhea, nausea, vomiting, stomach pain, flatulence, headache, and upper respiratory tract infections. Other potential side effects can include a metallic taste, constipation, loss of appetite, swelling of hands and legs (edema), drowsiness, dizziness, dry mouth, sore throat, and joint pain. A rare but serious side effect associated with metformin is lactic acidosis, which is a medical emergency. Symptoms include muscle pain or weakness, dizziness, tiredness, difficulty breathing, nausea, vomiting, stomach pain, or a slow heart rate.

Is MACSITA M XR 50/500 MG TABLET safe during pregnancy or breastfeeding?

MACSITA M XR 50/500 MG TABLET is generally not recommended during pregnancy or breastfeeding. Sitagliptin is not recommended in pregnancy due to limited information on its effects on a developing baby. Similarly, sitagliptin is not usually recommended while breastfeeding, as it is unknown how much passes into breast milk. Both sitagliptin and metformin are secreted into the milk of lactating rats. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as they may recommend alternative, safer medications.

Can it be taken with other medications?

MACSITA M XR can interact with other medications. Concomitant use with insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycemia), and a dose adjustment of these medications may be necessary. Drugs that interfere with metformin's renal clearance, such as cimetidine, digoxin, dolutegravir, morphine, ranolazine, and vandetanib, can increase the systemic exposure to metformin and raise the risk of lactic acidosis. Other medications like diuretics, corticosteroids, thyroid products, estrogens, and some blood pressure medicines can also affect blood glucose control. Always inform your doctor about all other medicines, vitamins, and herbal products you are taking.

What precautions should be taken?

Before taking MACSITA M XR, inform your doctor if you have any liver, kidney, or heart problems, high blood cholesterol levels, severe systemic infections, or have recently experienced severe dehydration due to vomiting or diarrhea. Regular monitoring of blood sugar levels and kidney function tests may be conducted by your doctor during treatment. Avoid or limit alcohol consumption while on this medication, as it can increase the risk of lactic acidosis. Do not drive or operate machinery if you experience dizziness or sleepiness. You may need to temporarily stop taking this medicine if you are dehydrated, planning surgery, or undergoing an X-ray procedure involving dye.

What happens if a dose is missed?

If you miss a dose of MACSITA M XR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take extra medicine or a double dose to make up for a missed one.

How should it be stored?

MACSITA M XR should be stored in a closed container at room temperature, generally between 68°F to 77°F (20°C to 25°C), away from heat, moisture, and direct light. Keep the cap tightly closed and keep the medicine out of the sight and reach of children. It should also be stored in accordance with national regulations and kept away from strong oxidizing agents.