Britzilam Sr 200mg Tab

BRITZILAM SR 200MG TABLET

Name

• Brand Name: Britzilam SR 200mg Tablet
• Common Name: Brivaracetam Sustained Release Tablets 200 mg

Composition Each film-coated sustained-release tablet contains:

• Active Ingredient: Brivaracetam I.P. 200 mg
• Excipients: Microcrystalline Cellulose, Hypromellose (HPMC), Purified Water, Poly Ethylene Oxide, Magnesium Stearate, Purified Talc, Colloidal Silicon Dioxide, Ready mix (EP-S-199), Isopropyl Alcohol, Methylene chloride. Colour: Titanium Dioxide I.P.

Uses Britzilam SR 200mg Tablet is an anti-epileptic medication indicated as adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy. It can be used alone or in combination with other anti-epileptic drugs to control various types of seizures, including myoclonic, partial-onset, and primary generalized tonic-clonic (grand mal) seizures. It works by attaching to specific sites (SV2A) on nerve cells to suppress abnormal electrical activity in the brain, thereby preventing the spread of electrical signals that cause seizures.

Dosage and Administration Britzilam SR 200mg Tablet is for oral use. It should be swallowed whole with liquid and must not be chewed, crushed, or broken. It can be taken with or without food, preferably at the same time each day for consistent levels in the body. The recommended starting dose for adults is typically 50 mg/day or 100 mg/day, administered in two equally divided doses (morning and evening). The dose may be adjusted based on individual patient response and tolerability, up to a maximum of 200 mg/day, which is then often recommended as a once-daily dose for those requiring 200 mg/day. It is typically prescribed for long-term use.

Side Effects Common side effects include:

• Drowsiness, sleepiness, fatigue
• Dizziness, vertigo, balance disorder
• Nausea, vomiting
• Headache
• Mood changes, agitation, aggression, irritability, anxiety, depression
• Decreased appetite
• Cough, upper respiratory tract infections
• Neutropenia (decrease in white blood cells)

Serious side effects include:

• Suicidal thoughts or behavior
• Psychotic disorder
• Type I hypersensitivity

Precautions

• Alcohol: Avoid consuming alcohol as it is deemed unsafe and may increase drowsiness, dizziness, and issues with memory and attention.
• Driving and Operating Machinery: This medicine may cause drowsiness, dizziness, and affect vision or alertness. Do not drive or operate heavy machinery until you know how the medicine affects you.
• Pregnancy and Breastfeeding: It is not recommended during pregnancy or breastfeeding as the effects on the unborn baby or newborn are not fully known. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Liver/Kidney Conditions: Exercise caution and inform your doctor if you have liver or kidney problems, as dose adjustments may be necessary. It is not recommended in end-stage renal disease due to lack of clinical data.
• Sudden Discontinuation: Do not stop taking Britzilam SR suddenly without consulting your doctor, as abrupt cessation can worsen seizure control, increase the frequency/severity of seizures, or lead to uncontrolled seizures.
• Suicidal Ideation: A small increased risk of suicidal thoughts and behavior has been reported in patients treated with anti-epileptic medicines. Contact your doctor immediately if you experience any such thoughts.
• Drug Interactions: Inform your doctor about all other medicines you are taking. Britzilam SR may interact with Rifampicin (a medicine used for bacterial infections) and Carbamazepine.
• Excipients: Britzilam SR film-coated tablets contain lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should not take this medicine.

Storage Store protected from moisture, at a temperature not exceeding 30°C. Keep all medicines out of reach of children.

Here are frequently asked questions about BRITZILAM SR 200MG TAB by TORRENT PHARMACEUTICALS LTD, along with concise answers:

What is BRITZILAM SR 200MG TAB used for?

BRITZILAM SR 200MG TAB, containing Brivaracetam, is an anti-epileptic medication primarily used as an add-on therapy for treating partial-onset seizures in patients 16 years of age and older with epilepsy. It helps to control various types of seizures by calming excessive electrical activity in the brain.

How does BRITZILAM SR 200MG TAB work?

This medicine works by binding to a specific protein called synaptic vesicle glycoprotein 2A (SV2A) on the surface of nerve cells in the brain. This action helps to regulate the release of neurotransmitters, stabilizing abnormal electrical activity in the brain and thereby reducing the frequency and intensity of seizures.

What is the usual dosage for BRITZILAM SR 200MG TAB?

For adults, the recommended starting dose is typically 50 mg/day or 100 mg/day, usually taken in two equally divided doses (morning and evening). Your doctor may adjust the dose based on your response and tolerability, within a range of 50 mg/day to 200 mg/day. BRITZILAM SR 200 mg tablets are often recommended once daily for those requiring a 200 mg/day dose. The tablets should be swallowed whole with liquid and can be taken with or without food. Do not chew, crush, or break the tablets.

What are the possible side effects of BRITZILAM SR 200MG TAB?

Common side effects include sleepiness (somnolence), dizziness, and fatigue. Other reported side effects may include nausea, vomiting, headache, and changes in mood or behavior such as agitation, aggression, or irritability. In some cases, more serious side effects like suicidal thoughts or behavioral changes have been reported. It is important to contact your doctor immediately if you experience any significant mood changes or thoughts of self-harm.

Is BRITZILAM SR 200MG TAB safe during pregnancy or breastfeeding?

BRITZILAM SR 200MG TAB is generally not recommended during pregnancy or breastfeeding because there is limited information available on its safety and potential effects on the unborn baby or newborn. If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor to discuss the benefits and risks of taking this medicine.

Can BRITZILAM SR 200MG TAB be taken with other medications?

It is important to inform your doctor about all other medications, supplements, and herbal remedies you are currently taking. BRITZILAM SR may interact with certain drugs. For instance, Rifampicin and St. John's Wort may require dose adjustments of Brivaracetam. Co-administration with Carbamazepine may increase exposure to its active metabolite, and Brivaracetam can also increase plasma concentrations of Phenytoin. No added therapeutic benefit was observed when Brivaracetam was co-administered with Levetiracetam.

What precautions should be taken while taking BRITZILAM SR 200MG TAB?

• Do not stop taking BRITZILAM SR abruptly without consulting your doctor, as sudden discontinuation can worsen seizures.
• Report any new or worsening depression, unusual changes in mood or behavior, or thoughts of self-harm to your doctor immediately.
• If you have liver problems, your doctor may need to adjust your dose.
• Avoid driving or operating heavy machinery until you know how the medicine affects you, as it can cause sleepiness, dizziness, or affect your balance and coordination.
• Alcohol should be avoided as it may intensify side effects like dizziness and drowsiness.
• If you have kidney problems, inform your doctor, as dose adjustments might be necessary. It is not recommended for patients with end-stage renal disease undergoing dialysis due to a lack of data.
• Swallow the tablet whole; do not chew, crush, or break it.

What happens if a dose of BRITZILAM SR 200MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should BRITZILAM SR 200MG TAB be stored?

BRITZILAM SR 200MG TAB should be stored protected from moisture, at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.