Lupisulin M 30 (30/70) 100 Iu/ml 3 Ml Cartridge (5 Cartridge)

LUPISULIN M 30 (30/70) 100 IU/ML 3 ML CARTRIDGE

LUPISULIN M 30, manufactured by LUPIN LTD., is a pre-mixed insulin formulation designed for managing blood sugar levels in individuals with diabetes.

• Name:

  • Brand Name: LUPISULIN M 30
  • Common Name: Biphasic Isophane Insulin (a combination of Human Insulin and Isophane Insulin)

• Composition:

  • Each milliliter (ML) contains 100 International Units (IU) of insulin.
  • It is a biphasic formulation consisting of 30% Soluble Human Insulin (short-acting) and 70% Isophane Human Insulin (intermediate-acting).

• Uses: LUPISULIN M 30 is prescribed for the treatment of both Type 1 and Type 2 Diabetes Mellitus. It works by facilitating the reuptake of sugar into fat and muscle cells and suppressing glucose production in the liver, thereby improving glycemic control and maintaining consistent blood sugar levels. This helps reduce the risk of diabetes complications like retinopathy, nephropathy, and neuropathy.

• Dosage and Administration:

  • This medicine is administered subcutaneously (under the skin) in areas such as the upper thigh, abdomen, upper arm, or buttocks. It should never be administered intravenously.
  • It is typically injected 15-30 minutes before a meal, and a carbohydrate-containing meal or snack should be consumed within 20-30 minutes after the injection to prevent low blood sugar.
  • Patients should rotate injection sites within the same region to minimize the risk of lipodystrophy.
  • The exact dosage and frequency are determined by a healthcare professional based on individual medical conditions and blood glucose monitoring.

• Side Effects:

  • Common Side Effects: Hypoglycemia (low blood sugar), injection site reactions (pain, redness, itching, swelling), lipodystrophy (skin thickening or pits at the injection site), weight gain, and edema (swelling).
  • Serious Side Effects: While rare, severe allergic reactions are possible. Consult a doctor if any side effects are persistent or concerning.

• Precautions:

  • Contraindications: Do not use if you have hypoglycemia (low blood glucose levels) or are allergic to any of the ingredients.
  • Medical Conditions: Inform your doctor if you have kidney, liver, or heart problems, as dose adjustments may be necessary.
  • Alcohol: Avoid alcohol consumption as it can affect blood glucose levels and may lead to unpleasant side effects or increased drowsiness.
  • Driving and Machinery: This medicine may cause drowsiness or dizziness due to blood sugar fluctuations; exercise caution when driving or operating machinery.
  • Pregnancy and Breastfeeding: Generally considered safe if prescribed by a doctor.
  • Administration: Do not mix LUPISULIN M 30 with other insulins. Do not share needles or injection devices to prevent transmission of infections.

• Storage:

  • Unopened cartridges should be stored in a refrigerator at a temperature between 2°C and 8°C. Do not freeze.
  • Once opened, cartridges can be stored at room temperature (below 25-30°C) for up to 4 weeks.
  • Protect from light.

What is LUPISULIN M 30 used for?

LUPISULIN M 30 is a combination medicine containing human insulin and isophane insulin, primarily used to treat both Type 1 and Type 2 diabetes mellitus in adults and children. It helps manage blood sugar levels effectively throughout the day by controlling both mealtime and basal glucose levels.

How does LUPISULIN M 30 work?

This medicine works by combining a short-acting insulin (human insulin) and an intermediate-acting insulin (isophane insulin). The human insulin provides a rapid onset of action, while isophane insulin offers a more prolonged effect. Together, they help your body utilize circulating blood glucose by stimulating its uptake into muscle and fat cells and inhibiting the liver's production of glucose, thereby lowering blood sugar levels.

What is the usual dosage and how should it be administered?

The specific dosage of LUPISULIN M 30 is determined by your doctor, based on your individual needs. It is administered as an injection subcutaneously (under the skin) in areas like the thigh, upper arm, or abdomen. You should inject it 15 to 30 minutes before a meal or within 20 minutes after starting a meal. It's crucial to rotate the injection sites continuously within the same region to prevent skin issues.

What are the possible side effects of LUPISULIN M 30?

The most common side effect is low blood sugar (hypoglycemia), which can manifest as lightheadedness, dizziness, anxiety, nervousness, tiredness, hunger, headache, shaking, sweating, or pale skin. Other possible side effects include reactions at the injection site such as pain, redness, swelling, itching, rash, or lipodystrophy (skin thickening or small pits/shrinkage of fat tissue). Some individuals may also experience weight gain, edema (swelling due to fluid retention), nausea, or vomiting.

Is LUPISULIN M 30 safe during pregnancy or breastfeeding?

LUPISULIN M 30 is generally considered safe for use during pregnancy if prescribed by your doctor. However, close monitoring of blood sugar levels is advised as insulin dose requirements may change with each trimester. It is also considered safe for use while breastfeeding, though your insulin dosage might need adjustment.

Can LUPISULIN M 30 be taken with other medications?

It's important to inform your doctor about all other medications you are taking, as some can interact with LUPISULIN M 30. For instance, certain medicines like beta-blockers (e.g., Metoprolol, Propranolol, Atenolol), Clonidine, Guanethidine, and Reserpine can mask the symptoms of low blood sugar. Combining insulin with other antidiabetic medicines may increase the risk of hypoglycemia. Additionally, using thiazolidinediones (TZDs) with insulin has been linked to an increased risk of heart failure.

What precautions should be taken while using LUPISULIN M 30?

Regularly monitor your blood glucose levels as advised by your doctor. Always carry a quick source of sugar (like candy or fruit juice) to treat sudden drops in blood sugar. Rotate your injection sites to prevent skin changes such as lipodystrophy. Avoid skipping or delaying meals, as this can lead to fluctuations in blood sugar. Inform your doctor if you have liver, kidney, or heart problems or thyroid disorders. Exercise caution when driving, as both high and low blood sugar levels can impair your ability. Do not stop taking LUPISULIN M 30 without consulting your doctor. Also, avoid consuming alcohol, as it can interfere with how insulin works and increase the risk of both low and high blood sugar levels. Do not share your insulin device or needles with others.

What happens if a dose is missed?

Missing a dose of LUPISULIN M 30 can lead to elevated blood sugar levels. If you remember soon after the missed dose, take it. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can cause a dangerous drop in blood glucose.

How should LUPISULIN M 30 be stored?

Unopened cartridges/vials of LUPISULIN M 30 should be stored in a refrigerator between 2°C and 8°C. Do not freeze the medicine. Once opened, the cartridge/vial can be stored at room temperature (typically below 25°C or 30°C, depending on specific product instructions) for up to 4 weeks (28 days). Keep it out of reach of children and away from direct sunlight.