Lupisit Dm 10/500 Tablet

LUPISIT DM 10/500 TABLET

LUPISIT DM 10/500 TABLET, manufactured by Lupin Ltd., is a fixed-dose combination medication used in the management of type 2 diabetes mellitus. It is designed to help control blood sugar levels in adults when diet and exercise alone are insufficient, or when existing therapies (like metformin monotherapy or dual therapy) do not provide adequate glycemic control.

Composition Each tablet contains:

• Dapagliflozin: 10 mg
• Sitagliptin Phosphate: 50 mg
• Metformin Hydrochloride: 500 mg

These active ingredients work synergistically to lower blood glucose. Dapagliflozin (an SGLT2 inhibitor) promotes glucose excretion via urine. Metformin (a biguanide) reduces hepatic glucose production and improves insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) enhances incretin hormone levels, which stimulate insulin release and decrease glucagon secretion.

Uses LUPISIT DM 10/500 TABLET is primarily prescribed for:

• Treatment of type 2 diabetes mellitus in adults.
• Improvement of glycemic control.
• Can aid in weight management and may help reduce cardiovascular risk in some patients.

Dosage and Administration

• Typically taken once or twice daily, as prescribed by your doctor.
• It is crucial to take the tablet with meals to help reduce the risk of stomach upset.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Your doctor will determine the appropriate dosage based on your individual needs, response to medication, and other concurrent treatments.
• Regular monitoring of blood sugar levels is essential to ensure effectiveness and allow for dosage adjustments.

Side Effects Common side effects may include:

• Nausea, vomiting, diarrhea, stomach pain, flatulence
• Headache, drowsiness, dizziness
• Genital infections, urinary tract infections, increased or more frequent urination
• Upper respiratory tract infections, cough, influenza, back pain
• Dry mouth, decreased weight

Serious side effects, though rare, can occur and require immediate medical attention:

• Lactic acidosis (symptoms include weakness, difficulty breathing, unusual muscle pain, stomach pain)
• Kidney problems
• Acute pancreatitis (severe, persistent abdominal pain with or without nausea/vomiting)
• Severe allergic reactions (rash, hives, swelling of face/lips/tongue/throat, difficulty breathing or swallowing)

Precautions

• Contraindications: Not recommended for patients with severe kidney impairment, end-stage renal disease, or those on dialysis. It should also be avoided in cases of severe liver disease, heart failure, respiratory failure, acute metabolic acidosis (including diabetic ketoacidosis or lactic acidosis), type 1 diabetes mellitus, diabetic pre-coma, dehydration, severe infection, or recent myocardial infarction.
• Alcohol Consumption: Avoid excessive alcohol intake, as it can increase the risk of side effects such as drowsiness, dizziness, and lactic acidosis.
• Pregnancy and Breastfeeding: LUPISIT DM 10/500 TABLET is generally not recommended during pregnancy or breastfeeding. Consult your doctor for alternative treatment options.
• Kidney and Liver Function: Use with caution in patients with existing kidney or liver problems. Regular monitoring of kidney and liver function tests is advisable.
• Hypersensitivity: Do not take this medicine if you have a known allergy to Dapagliflozin, Metformin, Sitagliptin, or any other components of the tablet.
• Driving and Operating Machinery: This medication may cause dizziness or blurred vision. Exercise caution when driving or operating heavy machinery until you know how the medicine affects you.
• Drug Interactions: Inform your doctor about all prescription, non-prescription, and herbal supplements you are taking. LUPISIT DM 10/500 TABLET may interact with other antidiabetic medications (like insulin or sulfonylureas), diuretics, certain antifungals (e.g., ketoconazole, itraconazole), antivirals (e.g., ritonavir), antibacterials (e.g., clarithromycin), and corticosteroids.

Storage Store LUPISIT DM 10/500 TABLET in a cool, dry place, ideally below 30°C. Protect it from moisture and direct sunlight. Keep the medicine out of the sight and reach of children and pets.

Here are the frequently asked questions about LUPISIT DM 10/500 Tablet, along with their answers:

What is LUPISIT DM 10/500 Tablet used for?

LUPISIT DM 10/500 Tablet is used to manage type 2 diabetes mellitus in adults. It helps improve blood sugar control, especially when diet and exercise alone, or therapy with metformin alone or dual therapy with metformin and either dapagliflozin or sitagliptin, are not sufficient. Additionally, it may aid in weight management and help reduce cardiovascular risk in some individuals.

How does LUPISIT DM 10/500 Tablet work?

LUPISIT DM 10/500 Tablet is a combination of three active ingredients: Dapagliflozin (10 mg), Sitagliptin (50 mg), and Metformin (500 mg).

• Dapagliflozin works by reducing the reabsorption of glucose in the kidneys, leading to more glucose being excreted through urine, thereby lowering blood glucose levels.
• Metformin decreases glucose production in the liver and reduces glucose absorption from the intestines. It also improves the body's response to insulin.
• Sitagliptin enhances the levels of incretin hormones, which stimulate insulin release and decrease glucagon secretion, contributing to lower blood sugar levels.

What is the usual dosage for LUPISIT DM 10/500 Tablet?

LUPISIT DM 10/500 Tablet is typically taken once or twice daily with meals, as prescribed by your doctor. It's important to swallow the tablet whole with a glass of water and not crush or chew it. Your doctor will determine the appropriate dosage based on your individual needs and response to the medication.

What are the possible side effects of LUPISIT DM 10/500 Tablet?

Common side effects may include genital infections, common cold, diarrhea, headache, nausea, influenza, back pain, cough, increased or frequent urination, stomach pain, dizziness, and low blood glucose (hypoglycemia). Serious but rare side effects can include lactic acidosis (signs include weakness, difficulty breathing, or stomach pain), ketoacidosis (nausea, vomiting, confusion, or fruity breath), painful or persistent genital or urinary infections, and pancreatitis (severe stomach pain or nausea). Seek immediate medical attention if you experience serious side effects.

Is LUPISIT DM 10/500 Tablet safe during pregnancy or breastfeeding?

LUPISIT DM 10/500 Tablet is generally not recommended during pregnancy or breastfeeding. It is important to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as some ingredients may harm the baby or affect milk production.

Can LUPISIT DM 10/500 Tablet be taken with other medications?

LUPISIT DM 10/500 Tablet can interact with certain medications. Inform your doctor about all other medicines, supplements, and herbal products you are taking.

• Diuretics (water pills like furosemide or hydrochlorothiazide) can increase the risk of volume depletion.
• Insulin and insulin secretagogues (like glimepiride) may increase the risk of hypoglycemia, potentially requiring a lower dose of these medications.
• Other interacting medications can include certain antifungals (e.g., ketoconazole, itraconazole), antivirals (e.g., ritonavir), and corticosteroids.

What precautions should be taken while using LUPISIT DM 10/500 Tablet?

• Kidney and Liver Issues: This medicine is not recommended for individuals with severe kidney impairment, end-stage renal disease, or liver disease due to an increased risk of lactic acidosis from metformin. Regular monitoring of kidney and liver function is advised.
• Metabolic Acidosis: Avoid if you have metabolic acidosis, including diabetic ketoacidosis.
• Alcohol: Excessive alcohol consumption should be avoided as it can enhance the effect of metformin on lactate metabolism and increase the risk of hypoglycemia.
• Dehydration: Drink plenty of fluids to help prevent dehydration.
• Hypersensitivity: Do not take if you have a known allergy to Dapagliflozin, Metformin, Sitagliptin, or any other components of the tablet.
• Children and Elderly: It is not recommended for children under 18. Older patients may be more susceptible to side effects.
• Driving: If you experience dizziness or blurred vision, avoid driving or operating heavy machinery.

What happens if a dose is missed?

If you miss a dose of LUPISIT DM 10/500 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should LUPISIT DM 10/500 Tablet be stored?

Store LUPISIT DM 10/500 Tablet in a cool, dry place at room temperature, ideally below 30°C. Protect it from moisture and heat. Always ensure that the medicine is kept out of reach of children and pets.