Encorate 300 Mg Tablet (10 Tab)

ENCORATE 300 MG TABLET (10 TAB)

Encorate 300 MG Tablet is an anticonvulsant medication manufactured by Sun Pharma Laboratories Ltd.. It is also commonly available as Encorate Chrono 300 mg.

Composition Each Encorate 300 MG Tablet contains 300 mg of active ingredients, typically comprising Sodium Valproate and Valproic Acid. For instance, Encorate Chrono 300 mg controlled-release tablets contain Sodium valproate BP 199.8 mg and Valproic acid USP 87 mg. Sodium valproate works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, a neurotransmitter that helps calm nerve activity and control seizures and mood.

Uses Encorate 300 MG Tablet is prescribed for a range of neurological and psychiatric conditions:

• Epilepsy/Seizures: It is used to manage various types of epilepsy, including partial seizures, absence seizures (petit mal), generalized tonic-clonic seizures (grand mal), myoclonic seizures, atonic seizures, and mixed seizures.
• Bipolar Disorder: It is effective in stabilizing mood and managing manic episodes associated with bipolar disorder.
• Migraine Prophylaxis: It can be used to prevent and reduce the frequency of migraine headaches.

Dosage and Administration Encorate 300 MG Tablet is for oral administration and should be taken as directed by a healthcare professional, preferably with or after food to minimize gastrointestinal upset. The dosage varies based on the patient's condition, age, and response to treatment.

• Epilepsy (Adults): An initial dose of 600 mg daily, given in two divided doses, is common. The dose may be increased by 200 mg/day at 3-day intervals, up to a maximum of 2.5 g daily. The usual maintenance dose is 1-2 g daily (20-30 mg/kg daily).
• Bipolar Disorder: An initial dose of 600 mg daily, with a typical maintenance dosage of 1000-2000 mg daily.
• Migraine Prophylaxis: Doses typically range from 400-600 mg daily, though some patients may require 1000-1500 mg daily. Tablets should be swallowed whole and not chewed or crushed.

Side Effects Common side effects may include:

• Nausea, vomiting, diarrhea, abdominal pain.
• Dizziness, drowsiness, sleepiness, headache.
• Tremors.
• Hair loss or changes in hair color/texture.
• Weight gain due to increased appetite.
• Irregular menstrual periods.
• Blurred vision, skin rashes, loss of appetite, gum swelling.

Serious side effects, though rare, can include severe pancreatitis, liver injury, bleeding disorders, hyperammonemia, and an increased risk of suicidal thoughts. Immediate medical attention is required if such effects are observed.

Precautions

• Pregnancy and Breastfeeding: Encorate 300 MG Tablet can be harmful to an unborn baby, potentially causing birth defects and developmental issues. It is contraindicated during pregnancy unless specifically prescribed by a doctor, and effective contraception should be used by women of childbearing potential. Small quantities of the medicine can pass into breast milk.
• Liver and Kidney Function: Use with caution in patients with a history of liver disease, and it is not recommended for those with active or severe liver conditions. Liver function should be monitored regularly. Caution is also advised in patients with renal impairment.
• Alcohol Consumption: Avoid alcohol while taking this medicine, as it can intensify side effects such as drowsiness and dizziness.
• Driving and Operating Machinery: Due to potential drowsiness, dizziness, or blurred vision, patients should avoid driving or operating heavy machinery until they are certain the medicine does not impair their abilities.
• Drug Interactions: Encorate 300 MG Tablet can interact with other medications, including certain anticonvulsants (e.g., phenytoin, carbamazepine, lamotrigine), blood thinners (e.g., aspirin, warfarin), antidepressants, and benzodiazepines. Patients should inform their doctor about all other medications they are taking.
• Other Conditions: Caution is advised in patients with bleeding disorders, systemic lupus erythematosus, urea cycle disorders, porphyria, diabetes, or immune system disorders. It is not recommended for children under 2 years of age. Abrupt discontinuation of the medication should be avoided.

Storage Store Encorate 300 MG Tablet at room temperature in a tightly closed container. Keep out of reach and sight of children.

Here are the most frequently asked questions about ENCORATE 300 MG TABLET (10 TAB) by SUN PHARMA LABORATORIES LTD., along with concise answers:

What is Encorate 300 mg Tablet used for?

Encorate 300 mg Tablet, containing sodium valproate, is primarily used to treat various types of epilepsy (seizures or fits). It is also prescribed for managing the manic phase of bipolar disorder and for the prevention of migraine headaches.

How does Encorate 300 mg Tablet work?

Encorate 300 mg Tablet works by increasing the levels of a natural chemical substance in the brain called Gamma-Aminobutyric Acid (GABA). This helps to decrease excessive and abnormal nerve activity in the brain, thereby controlling seizures and providing a calming effect that helps stabilize mood.

What is the usual dosage for Encorate 300 mg Tablet?

The dosage of Encorate 300 mg Tablet varies depending on the condition being treated, as well as the patient's age and body weight. For adults, an initial dose for epilepsy is often 600 mg per day, divided into two doses, preferably taken after food. The dose may be gradually increased by your doctor until seizure control is achieved, usually within a maintenance range of 1-2 grams daily (20-30 mg/kg daily). Always follow your doctor's specific instructions.

What are the possible side effects of Encorate 300 mg Tablet?

Common side effects can include nausea, vomiting, stomach pain, diarrhea, drowsiness, dizziness, tremors, headache, weight gain, and hair loss. These are usually mild and may subside over time. More serious but rare side effects can include liver problems, pancreatitis (inflammation of the pancreas), and blood disorders. You should report any severe or persistent side effects to your doctor.

Is Encorate 300 mg Tablet safe during pregnancy or breastfeeding?

Encorate 300 mg Tablet is contraindicated during pregnancy for women of childbearing potential due to a significant risk of birth defects (such as neural tube defects, facial, heart, and limb problems) and developmental problems in the baby. Women who can become pregnant must use effective contraception consistently and be enrolled in a pregnancy prevention program. For breastfeeding, small quantities of the medicine can pass into breast milk. It is recommended to consult your doctor to weigh the potential risks and benefits for your baby. Men taking sodium valproate should also use effective contraception with a partner and avoid sperm donation due to potential risks to the child's development.

Can Encorate 300 mg Tablet be taken with other medications?

Encorate 300 mg Tablet can interact with several other medications. These include other anti-epileptic drugs (like phenytoin, carbamazepine, lamotrigine), antidepressants, blood thinners (e.g., warfarin, aspirin), certain antibiotics (such as carbapenems), and benzodiazepines. Alcohol and other central nervous system depressants can also increase drowsiness. Always inform your doctor about all medicines, supplements, or herbal preparations you are taking to avoid potential interactions.

What precautions should be taken while taking Encorate 300 mg Tablet?

Your doctor may recommend monitoring your liver function before and during treatment, especially in the first six months. Use with caution if you have kidney or pancreatic disease, blood disorders, or a history of depression or suicidal thoughts. Do not suddenly stop taking the medicine, as this can worsen your condition or trigger seizures. Avoid consuming alcohol while on this medication as it can increase side effects. Due to potential drowsiness or dizziness, avoid driving or operating heavy machinery until you know how the medicine affects you.

What happens if a dose of Encorate 300 mg Tablet is missed?

If you miss a dose of Encorate 300 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you frequently miss doses, or are concerned, consult your doctor or pharmacist.

How should Encorate 300 mg Tablet be stored?

Store Encorate 300 mg Tablet in a cool, dry place, protected from light and moisture. Keep it out of the reach of children and pets. The ideal storage temperature is typically between 15°C and 30°C. Always check the expiration date and discard any unused medicine properly.