Glucomust Pm Tablet (10 Tab)

GLUCOMUST PM TABLET (10 TAB) by MANKIND PHARMA LTD.

Name: GLUCOMUST PM TABLET (Brand Name)

Composition: GLUCOMUST PM TABLET is a combination of three active ingredients:

• Glibenclamide (5 mg)
• Metformin (500 mg)
• Pioglitazone (15 mg)

Uses: This medication is primarily used for the management of Type 2 Diabetes Mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by single-drug therapy, diet, and exercise alone. It helps to lower high blood glucose levels, improve insulin sensitivity, reduce glucose production by the liver, and control blood sugar levels, particularly overnight.

Dosage and Administration: GLUCOMUST PM TABLET is designed to be taken orally, typically once daily in the evening, or as directed by a healthcare provider. It should be swallowed whole with a glass of water, preferably with food, and not chewed, crushed, or broken. Consistency in timing is important for optimal effectiveness.

Side Effects: Common side effects may include nausea, vomiting, diarrhea, stomach ache, headache, weight gain, swelling in legs (oedema), and hypoglycemia (low blood sugar). Serious side effects like lactic acidosis (a rare but severe buildup of lactic acid in the blood) or liver problems may occur, requiring immediate medical attention.

Precautions:

• Hypoglycemia: Patients should be aware of hypoglycemia symptoms (sweating, shaking, dizziness, confusion) and carry a quick source of sugar.
• Alcohol: Avoid alcohol consumption as it can increase the risk of lactic acidosis and hypoglycemia.
• Medical Conditions: Inform your doctor if you have kidney or liver disease, heart failure, or a history of bladder cancer, as these conditions may contraindicate its use or require dose adjustments.
• Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding.
• Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking due to potential drug interactions.

Storage: Store GLUCOMUST PM TABLET at room temperature, away from moisture and heat, and out of reach of children.

GLUCOMUST PM TABLET (10 TAB) by MANKIND PHARMA LTD. is a combination medication used to manage Type 2 Diabetes Mellitus. It contains three active ingredients: Glibenclamide, Metformin, and Pioglitazone.

What is GLUCOMUST PM TABLET used for?

GLUCOMUST PM TABLET is used in adults for the treatment of Type 2 Diabetes Mellitus, especially when blood sugar levels are not adequately controlled by diet, exercise, or single-drug therapy. It helps to lower high blood sugar levels, improve insulin sensitivity, control post-meal blood sugar, and manage insulin resistance.

How does GLUCOMUST PM TABLET work?

GLUCOMUST PM TABLET combines three different medicines that work synergistically.

• Glibenclamide: This belongs to the sulfonylurea class and works by stimulating the beta cells in the pancreas to release more insulin.
• Metformin: This is a biguanide that reduces glucose production in the liver and decreases the absorption of glucose from the intestines. It also enhances the body's sensitivity to insulin.
• Pioglitazone: This is a thiazolidinedione that improves the sensitivity of muscle and fat tissues to insulin, helping the body use insulin more effectively.

What is the usual dosage of GLUCOMUST PM TABLET?

The dosage of GLUCOMUST PM TABLET is determined by your doctor based on individual factors like the severity of your condition and your response to treatment. It is typically prescribed to be taken once daily, usually with the evening meal, swallowed whole with a glass of water. Do not chew, crush, or break the tablet, and do not alter the dosage without consulting your healthcare provider.

What are the possible side effects of GLUCOMUST PM TABLET?

Common side effects can include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, stomach ache, headache, weight gain, swelling in legs (edema), numbness, vision problems, and respiratory infections. Some serious but rare side effects include lactic acidosis (a build-up of lactic acid in the blood) and abnormal liver function. If you experience severe symptoms or any side effects worsen, seek immediate medical attention.

Is GLUCOMUST PM TABLET safe during pregnancy or breastfeeding?

GLUCOMUST PM TABLET is generally not recommended during pregnancy, especially in the second and third trimesters, as it may cause harmful effects to the unborn baby. Insulin is often the preferred option for managing diabetes during pregnancy. It is also not recommended for use in breastfeeding mothers as the active ingredients can pass into breast milk and may cause unwanted effects in nursing babies. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can GLUCOMUST PM TABLET be taken with other medications?

GLUCOMUST PM TABLET can interact with several medications. Inform your doctor about all other medications, supplements, and herbal products you are taking, as some can affect blood sugar control or increase the risk of side effects. Examples of interacting medications include certain ACE inhibitors, ARBs, thiazide diuretics, corticosteroids, pain medications (like ibuprofen), antibiotics, and oral contraceptives.

What precautions should be taken with GLUCOMUST PM TABLET?

Several precautions should be observed:

• Alcohol: Avoid consuming alcohol as it can increase the risk of hypoglycemia and lactic acidosis.
• Kidney and Liver Disease: Use with caution, and it is often contraindicated in severe cases of kidney or liver disease, as it can increase the risk of lactic acidosis and other side effects.
• Heart Conditions: Exercise caution if you have a history of heart disease or heart failure, as pioglitazone can cause fluid retention.
• Hypoglycemia: Be aware of the symptoms of low blood sugar (sweating, dizziness, headache, confusion) and carry a quick source of sugar.
• Driving/Operating Machinery: This medicine may cause vision problems or low blood sugar, which can affect concentration. Do not drive or operate heavy machinery if you experience these effects.
• Diabetic Ketoacidosis and Type 1 Diabetes: This medicine is not recommended for patients with Type 1 diabetes mellitus or diabetic ketoacidosis.

What happens if a dose is missed?

If you miss a dose of GLUCOMUST PM TABLET, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of side effects.

How should GLUCOMUST PM TABLET be stored?

Store GLUCOMUST PM TABLET at room temperature, away from moisture and heat. Keep it in its original packaging, away from direct sunlight, and out of sight and reach of children. Do not use the medicine after the expiry date.