Glucoryl M2 Forte Tablet

GLUCORYL M2 FORTE TABLET

Name

Brand Name: GLUCORYL M2 FORTE TABLET Manufacturer: ALKEM LABORATORIES LTD

Composition

Each tablet contains:

• Glimepiride: 2 mg
• Metformin Hydrochloride: 1000 mg

Uses

GLUCORYL M2 FORTE TABLET is an anti-diabetic medication primarily prescribed for adults with Type 2 Diabetes Mellitus. It is indicated when blood sugar levels are not adequately controlled by diet and exercise alone, or by a single antidiabetic agent such as glimepiride or metformin.

This medication helps to:

• Lower blood sugar levels effectively.
• Improve insulin sensitivity, making the body's tissues more responsive to insulin.
• Prevent and manage diabetes-related complications, including kidney damage, eye problems, nerve issues, and limb amputations.
• Reduce the risk of cardiovascular events such as heart attack and stroke.

Dosage and Administration

GLUCORYL M2 FORTE TABLET should be taken orally with food, typically once daily, or as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. It is advisable to take the medicine at a fixed time each day to achieve optimal therapeutic benefits. The specific dosage and duration of treatment will be determined by the doctor based on the patient's individual medical condition, blood sugar levels, and response to treatment.

Side Effects

Common Side Effects:

• Stomach pain
• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Metallic taste in the mouth
• Taste disturbance
• Flatulence
• Hypoglycemia (low blood sugar levels), which can manifest as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, and frequent urination.

Serious/Rare Side Effects (Seek immediate medical attention if experienced):

• Lactic acidosis (a serious buildup of lactic acid in the blood), indicated by symptoms like muscle pain, difficulty breathing, tiredness, cold feeling in arms and legs, nausea, vomiting, stomach pain, or slow heart rate.
• Abnormal liver function, including jaundice (yellowing of the skin or eyes), problems with bile flow (cholestasis), inflammation of the liver (hepatitis), or liver failure.
• Severe allergic reactions, such as skin rash, hives, increased sensitivity to the sun, inflammation of blood vessels, difficulty breathing, a fall in blood pressure, and shock.
• Severe hypoglycemia, including loss of consciousness, seizures, or coma.
• Vitamin B12 deficiency with prolonged use, which may lead to anemia, fatigue, pale skin, and shortness of breath or headache.

Precautions

• Contraindications: Do not take if allergic to glimepiride, metformin, or any other components of the tablet. It is contraindicated in patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, diabetic pre-coma, severe kidney or liver failure, metabolic acidosis, dehydration, severe infections, shock, and acute heart problems.
• Pregnancy and Breastfeeding: Not recommended for use during pregnancy as it may harm the unborn baby. It should also be avoided by nursing mothers as the medicine may pass into breast milk.
• Alcohol Consumption: Avoid alcohol consumption while taking this medicine as it may increase the risk of lactic acidosis and can affect blood sugar levels.
• Hypoglycemia: Be aware of the symptoms of low blood sugar and always carry a quick source of sugar (e.g., glucose tablets, honey, or fruit juice) for immediate relief.
• Medical Conditions: Inform your doctor if you have a history of liver or kidney problems, heart conditions (especially congestive heart failure), or circulation problems, as dose adjustments or alternative treatments may be necessary.
• Driving and Operating Machinery: This medicine may decrease alertness due to the risk of hypoglycemia. Drive or operate machinery only if you are alert.
• Drug Interactions: Inform your doctor about all other medicines, supplements, or herbal products you are currently taking to avoid possible interactions. Interactions may occur with other antidiabetic agents, ACE inhibitors, diuretics, certain antibiotics, NSAIDs, fibrates, fluoxetine, allopurinol, probenecid, and sulfinpyrazone.
• Surgery: Inform your doctor if you are scheduled for surgery, as dose adjustments may be required.
• Pediatric Use: Not suitable for use in children and adolescents under 18 years of age.

Storage

Store GLUCORYL M2 FORTE TABLET in a cool and dry place, typically below 30°C. Protect from light and keep it out of reach and sight of children. Do not use the medicine after the expiry date.

Here are the most frequently asked questions about GLUCORYL M2 FORTE TABLET by ALKEM LABORATORIES LTD, along with their answers:

What is Glucoryl M2 Forte Tablet used for?

Glucoryl M2 Forte Tablet is primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and a single antidiabetic agent are not sufficient to control blood sugar levels. This medicine helps improve blood sugar control and prevents severe complications of uncontrolled diabetes, such as kidney damage, blindness, nerve problems, limb amputations, and cardiovascular events like heart attack and stroke.

How does Glucoryl M2 Forte Tablet work?

Glucoryl M2 Forte Tablet contains two active ingredients: Glimepiride and Metformin. Glimepiride works by stimulating the beta cells in the pancreas to release more insulin, which helps lower blood sugar levels and increases insulin sensitivity in the body's tissues. Metformin reduces the amount of glucose produced by the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin.

What is the usual dosage for Glucoryl M2 Forte Tablet?

The dosage of Glucoryl M2 Forte Tablet is determined by your doctor based on your individual health condition and response to the medicine. It is typically taken once daily with a full meal, preferably in the evening. You should swallow the tablet whole with a glass of water and not crush or chew it. Always follow your doctor's instructions regarding the dose and duration of treatment.

What are the possible side effects of Glucoryl M2 Forte Tablet?

Common side effects may include diarrhea, nausea, vomiting, abdominal discomfort or pain, indigestion, flatulence, headache, altered taste, and low blood sugar (hypoglycemia). More serious but rare side effects can include lactic acidosis (a serious build-up of lactic acid in the blood), severe allergic reactions, inflammation of the liver, and vitamin B12 deficiency with long-term use. If you experience any severe or persistent side effects, consult your doctor.

Is Glucoryl M2 Forte Tablet safe during pregnancy or breastfeeding?

Glucoryl M2 Forte Tablet is generally not recommended during pregnancy as it may be unsafe and could harm the unborn baby. It is also advised to avoid this medicine while breastfeeding, as it may pass into breast milk and potentially cause adverse effects in the baby. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.

Can Glucoryl M2 Forte Tablet be taken with other medications?

Glucoryl M2 Forte Tablet can interact with various other medications, including other antidiabetic agents (like insulin), certain heart medicines, blood thinners (e.g., warfarin), diuretics, corticosteroids, and some antibiotics or antifungal drugs. These interactions can affect its efficacy or increase the risk of side effects like low blood sugar. It is crucial to inform your doctor about all prescription, over-the-counter medicines, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using Glucoryl M2 Forte Tablet?

You should avoid alcohol consumption while taking this medicine as it can increase the risk of lactic acidosis and low blood sugar. Inform your doctor if you have kidney or liver disease, heart conditions, type 1 diabetes, diabetic ketoacidosis, or a history of severe infections. Regular monitoring of your blood sugar levels is essential, and you should always carry a quick source of sugar (like glucose tablets or juice) to manage episodes of hypoglycemia. Do not stop taking the medicine without consulting your doctor.

What happens if a dose of Glucoryl M2 Forte Tablet is missed?

If you miss a dose of Glucoryl M2 Forte Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one without consulting your doctor, as this can lead to dangerously low blood sugar levels.

How should Glucoryl M2 Forte Tablet be stored?

Store Glucoryl M2 Forte Tablet in a cool and dry place, away from direct sunlight. It should be kept at room temperature, generally between 15-25°C or below 30°C. Always keep the medicine out of reach and sight of children and do not use it after its expiry date.