Doxinate 24 Tab

DOXINATE 24 TAB by MANEESH HEALTHCARE

Name:

• Brand Name: Doxinate 24 Tablet (also referred to as Doxinate 24 Tablet ER)
• Manufacturer: Maneesh Pharmaceuticals Ltd.

Composition:

• Active Ingredients: Each tablet contains Doxylamine Succinate 20 mg and Pyridoxine Hydrochloride (Vitamin B6) 20 mg.

Uses: Doxinate 24 Tablet is primarily used to prevent and treat nausea and vomiting during pregnancy, a condition commonly known as morning sickness. It is prescribed when dietary changes or other non-medical interventions do not provide sufficient relief. Doxylamine succinate, an antihistamine, works by blocking certain chemicals in the body that cause nausea and vomiting. Pyridoxine hydrochloride, or Vitamin B6, helps by addressing deficiencies that may contribute to nausea and vomiting in pregnancy and supports fetal development.

Dosage and Administration:

• Doxinate 24 Tablet should be taken as directed by a healthcare professional.
• It is generally advised to take the tablet on an empty stomach, preferably at a fixed time daily for optimal effectiveness.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• Do not discontinue the medicine abruptly without consulting your doctor, as this may lead to a recurrence of symptoms.

Side Effects: Common Side Effects:

• Dizziness
• Drowsiness or sleepiness
• Dry mouth
• Stomach pain or discomfort
• Constipation
• Headache
• Vertigo (spinning sensation)
• Blurred vision
• Rash or itching (less common but possible)

Serious Side Effects (Seek immediate medical attention if you experience):

• Signs of allergic reactions such as skin rash, itching, swelling of the face, lips, mouth, tongue, or throat causing difficulty in swallowing or breathing.
• Symptoms of overdose include restlessness, dry mouth, dilated pupils, increased dizziness, sleepiness, confusion, increased heartbeat, seizures, or severe muscle pain or weakness.

Precautions:

• Do not take Doxinate 24 Tablet if you are allergic to doxylamine, pyridoxine, or any other ingredients in the medicine.
• Avoid consuming alcohol while taking this medicine, as it can intensify dizziness and drowsiness.
• Doxinate 24 Tablet may cause dizziness and drowsiness, so caution is advised when driving or operating heavy machinery until you know how the medicine affects you.
• Inform your doctor if you have a history of asthma, glaucoma, stomach ulcers, intestinal or urinary bladder obstruction, or liver and kidney problems.
• The use of Doxinate 24 Tablet is not recommended during breastfeeding, as doxylamine can pass into breast milk and may cause sedation and irritability in the infant.
• Not recommended for individuals under 18 years of age as safety and efficacy have not been established.
• Interactions may occur with certain medications, including monoamine oxidase inhibitors (MAOIs), central nervous system depressants, sleeping pills, Levodopa, Phenobarb, and Phenytoin. Inform your doctor about all current medications, including over-the-counter and herbal preparations.

Storage:

• Store Doxinate 24 Tablet below 25°C (or below 30°C) in a cool, clean, and dry place.
• Protect the medicine from moisture, direct sunlight, and heat.
• Keep out of sight and reach of children and pets.

Here are the most frequently asked questions about DOXINATE 24 TAB:

What is DOXINATE 24 TAB used for?

DOXINATE 24 TAB is primarily used to treat nausea and vomiting during pregnancy, often referred to as morning sickness or Nausea and Vomiting in Pregnancy (NVP). It helps to alleviate these symptoms and also provides nutritional support with Vitamin B6.

How does DOXINATE 24 TAB work?

This medicine contains two active ingredients: Doxylamine and Pyridoxine (Vitamin B6). Doxylamine is an antihistamine that works by blocking certain chemical messengers (histamine) in the brain's "chemoreceptor trigger zone" which are responsible for causing nausea and vomiting. Pyridoxine (Vitamin B6) also has anti-nausea properties and helps by addressing any Vitamin B6 deficiency that might contribute to morning sickness during pregnancy, while also providing essential nutrition.

What is the usual dosage for DOXINATE 24 TAB?

The usual dosage is typically two tablets taken at bedtime. Your doctor may adjust the dosage, prescribing an additional tablet in the morning and/or mid-afternoon, depending on the severity of your symptoms. It should generally be taken on an empty stomach. Always swallow the tablet whole with water; do not crush, chew, or break it.

What are the possible side effects of DOXINATE 24 TAB?

Common side effects include drowsiness or sleepiness, dry mouth, constipation, dizziness, abdominal pain, weakness, lightheadedness, headache, blurred vision, and difficulty emptying your bladder completely (urinary retention). If any side effects persist or worsen, consult your doctor.

Is DOXINATE 24 TAB safe during pregnancy or breastfeeding?

DOXINATE 24 TAB is considered safe to use during all trimesters of pregnancy when prescribed by a doctor for nausea and vomiting.

However, its use is generally not recommended during breastfeeding because doxylamine can pass into breast milk and may cause drowsiness or irritability in the infant. It is crucial to consult your doctor if you are breastfeeding and considering this medication.

Can DOXINATE 24 TAB be taken with other medications?

It is important to inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. DOXINATE 24 TAB should be avoided with Central Nervous System (CNS) depressants such as alcohol, sleeping pills, sedatives, tranquilizers, opioid pain relievers, certain antidepressants, and some cough and cold medicines, as this combination can significantly increase drowsiness. It should also not be taken with Monoamine Oxidase Inhibitors (MAOIs). Additionally, pyridoxine in this medicine can reduce the effects of certain drugs like levodopa, phenobarbital, and phenytoin.

What precautions should be taken while using DOXINATE 24 TAB?

Due to potential drowsiness, you should avoid driving or operating heavy machinery until you understand how this medicine affects you. Alcohol should be avoided as it can intensify drowsiness and potentially harm the baby. Use with caution if you have underlying conditions such as asthma, glaucoma, urinary retention, gastrointestinal obstructive disorders, liver or kidney problems, or psychiatric disorders like depression. DOXINATE 24 TAB is not recommended for individuals under 18 years of age.

What happens if a dose of DOXINATE 24 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should DOXINATE 24 TAB be stored?

Store DOXINATE 24 TAB in a cool, dry place below 25°C or 30°C, away from direct sunlight and moisture. Keep it out of the sight and reach of children and pets.