Zoryl 0.5 Mg Tablet

ZORYL 0.5 MG Tablet

ZORYL 0.5 MG Tablet, manufactured by INTAS PHARMACEUTICALS LTD, is an oral anti-diabetic medication used to manage Type 2 Diabetes Mellitus in adults.

• Name:
  • Brand Name: Zoryl 0.5 MG Tablet
  • Common Name: Glimepiride
• Composition: Each tablet contains Glimepiride 0.5 mg.
• Uses: ZORYL 0.5 MG Tablet is prescribed for the management of Type 2 Diabetes Mellitus in adults, particularly when diet and exercise alone are insufficient to control blood sugar levels. It can be used as a standalone therapy or in combination with other anti-diabetic medicines or insulin. It works by stimulating the pancreas to release more insulin, thereby lowering blood glucose.
• Dosage and Administration:
  • Typically taken orally once daily, before or with the first main meal, usually breakfast.
  • The tablet should be swallowed whole with water and not chewed, crushed, or cut.
  • The recommended starting dose is usually 1 mg or 2 mg once daily.
  • Dosage adjustments are made by a healthcare professional based on individual blood glucose levels, with a usual maintenance dose of 1–4 mg once daily and a maximum recommended dose of 8 mg once daily.
• Side Effects:
  • Common: Low blood sugar levels (hypoglycemia), which can manifest as headache, nausea, dizziness, weakness, sweating, and shaking. Other common side effects include nausea, headache, dizziness, and weight gain.
  • Serious (less common): Allergic skin reactions (rash, hives, photosensitivity), flu-like symptoms, anemia, jaundice, liver dysfunction, and seizures.
• Precautions:
  • Hypoglycemia: This medicine can cause moderate to severe low blood sugar. Regular meals and carrying a fast-acting source of glucose are important.
  • Alcohol: Avoid or limit alcohol consumption, as it can increase the risk of hypoglycemia.
  • Pregnancy and Breastfeeding: ZORYL 0.5 MG Tablet is generally not recommended during pregnancy or breastfeeding, as Glimepiride may pass into breast milk and potentially harm the infant.
  • Medical Conditions: Contraindicated in patients with Type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, G6PD deficiency, or a known allergy to glimepiride or other sulfonylureas/sulfonamides. Use with caution in patients with pre-existing heart, kidney, or liver conditions.
  • Drug Interactions: Inform your doctor about all current medications, supplements, and herbal products, as ZORYL 0.5 MG Tablet can interact with various drugs, potentially affecting blood glucose levels.
  • Photosensitivity: The medicine can increase skin sensitivity to sunlight; protective measures like sunscreen or clothing are advised.
• Storage: Store the medicine at room temperature (below 25°C or 30°C) in its original packaging, protected from heat, moisture, and direct sunlight. Keep out of the reach of children.

Zoryl 0.5 MG Tablet, containing the active ingredient Glimepiride, is an oral medication primarily used to manage Type 2 Diabetes Mellitus. It helps to lower elevated blood sugar levels when diet and exercise alone are insufficient.

Here are some frequently asked questions about Zoryl 0.5 MG Tablet:

What is Zoryl 0.5 MG Tablet used for?

Zoryl 0.5 MG Tablet is used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus (non-insulin-dependent diabetes). It is typically used in conjunction with a healthy diet and regular exercise. It can also be prescribed alongside other diabetes medications or insulin to achieve better blood sugar control, helping to prevent serious complications such as kidney damage, eye problems, and nerve issues.

How does Zoryl 0.5 MG Tablet work?

Zoryl 0.5 MG Tablet belongs to a class of medications called sulfonylureas. It works by stimulating the beta cells in the pancreas to release more insulin. Additionally, it helps to improve the body's sensitivity to insulin, allowing peripheral tissues to absorb and utilize glucose more effectively, thereby reducing blood sugar levels.

What is the usual dosage for Zoryl 0.5 MG Tablet?

Zoryl 0.5 MG Tablet is usually taken once daily with breakfast or the first main meal of the day. The typical starting dose of glimepiride (the active ingredient) is 1 mg or 2 mg once daily, but for patients at increased risk of low blood sugar, such as the elderly or those with kidney impairment, a starting dose of 1 mg once daily may be recommended. Your doctor will determine the appropriate dosage based on your blood sugar levels and may adjust it in increments of 1 mg or 2 mg, not more frequently than every 1 to 2 weeks. The maximum recommended dose is 8 mg once daily.

What are the possible side effects of Zoryl 0.5 MG Tablet?

The most common side effect is low blood sugar (hypoglycemia), which can manifest as trembling, shaking, nervousness, anxiety, sweating, lightheadedness, dizziness, headache, fast heart rate, intense hunger, and fatigue. Other common side effects include headache, nausea, dizziness, weakness, and unexplained weight gain. More serious but less common side effects can include allergic skin reactions, liver dysfunction, and, in rare cases, severe allergic reactions or hemolytic anemia, especially in individuals with G6PD deficiency. There is also a warning that glimepiride may increase the risk of fatal heart problems compared to diet alone or diet plus insulin.

Is Zoryl 0.5 MG Tablet safe during pregnancy or breastfeeding?

Zoryl 0.5 MG Tablet is generally not recommended and may be unsafe to use during pregnancy. If you are pregnant or planning to become pregnant, your doctor may switch you to insulin therapy. Similarly, it is not recommended during breastfeeding as it may pass into breast milk and could potentially cause low blood sugar in the baby. Your doctor should be consulted to discuss the risks and benefits.

Can Zoryl 0.5 MG Tablet be taken with other medications?

Zoryl 0.5 MG Tablet can interact with many other medications, which may either increase its effect (leading to lower blood sugar) or decrease its effect (leading to higher blood sugar). Medications that can increase its blood sugar-lowering effect include certain antibiotics (like quinolones and chloramphenicol), antifungals (like fluconazole), ACE inhibitors, salicylates, and MAOIs. Conversely, drugs like thiazide diuretics, corticosteroids, and certain antipsychotics can decrease its effectiveness. It's crucial to inform your doctor about all prescription, over-the-counter medications, and herbal supplements you are taking to avoid potential interactions. For example, if also taking colesevelam, it should be taken at least 4 hours after glimepiride to prevent reduced absorption.

What precautions should be taken while on Zoryl 0.5 MG Tablet?

It is very important to recognize and promptly treat symptoms of low blood sugar, and always carry a quick source of sugar (like glucose tablets or fruit juice). Alcohol consumption should be avoided or severely limited as it can significantly increase the risk of hypoglycemia. Regular monitoring of blood sugar levels and HbA1C is essential. Inform your doctor if you have a sulfa allergy, G6PD deficiency, or severe kidney or liver disease, as this medication may not be suitable or may require dose adjustments. Also, report any unusual stress, infection, fever, trauma, or upcoming surgery, as these can affect blood sugar control. Zoryl 0.5 MG Tablet may also increase sensitivity to sunlight, so protective clothing and sunscreen are advised.

What happens if a dose of Zoryl 0.5 MG Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Zoryl 0.5 MG Tablet be stored?

Zoryl 0.5 MG Tablet should be stored at room temperature, typically between 20°C and 25°C (68°F and 77°F). It should be kept in its original packaging, away from heat, moisture, and direct light, and protected from freezing. Ensure the medication is kept out of reach of children and pets.