Mactor F

MACTOR F Tablet

MACTOR F is a combination medication manufactured by Macleods Pharmaceuticals Pvt Ltd, designed to manage high cholesterol and triglyceride levels, thereby reducing the risk of cardiovascular diseases.

Composition Each tablet contains:

• Atorvastatin (10 mg)
• Fenofibrate (160 mg)

Atorvastatin belongs to the statin class, working by inhibiting an enzyme crucial for cholesterol production in the liver, thus lowering "bad" cholesterol (LDL) and triglycerides. Fenofibrate, a fibric acid derivative, reduces triglycerides and increases "good" cholesterol (HDL) by enhancing the breakdown of fats in the bloodstream.

Uses MACTOR F is prescribed for:

• Hyperlipidemia: High levels of lipids (fats) in the blood.
• Mixed Dyslipidemia: Abnormal levels of cholesterol and triglycerides.
• Hypercholesterolemia: High total and LDL cholesterol.
• Hypertriglyceridemia: High triglyceride levels.
• Prevention of cardiovascular events: Reduces the risk of heart attack and stroke, particularly in individuals with dyslipidemia or metabolic syndrome.

Dosage and Administration Typically, one tablet is taken daily. It can be taken with or without food, but maintaining a consistent time each day is recommended to ensure stable drug levels. Swallow the tablet whole; do not chew, crush, or break it. Adherence to the prescribed dosage and duration is crucial, and discontinuation should only be done under medical advice.

Side Effects Common side effects may include:

• Muscle pain or weakness (myalgia)
• Headache
• Abdominal discomfort, stomach pain, nausea, diarrhea, constipation, flatulence, dyspepsia
• Elevated liver enzymes

Serious side effects, though rare, warrant immediate medical attention, such as severe, unexplained muscle pain with fever or weakness (signs of rhabdomyolysis), or yellowing of the skin/eyes (jaundice) indicating liver damage.

Precautions

• Liver Function: Regular liver function tests are necessary, especially for patients with a history of liver problems. MACTOR F is not recommended for severe liver or gallbladder issues.
• Kidney Function: Use with caution in patients with kidney problems, as dose adjustments and monitoring may be required.
• Muscle Pain: Report any unexplained muscle pain, tenderness, or weakness immediately.
• Drug Interactions: Inform your doctor about all medications, including over-the-counter drugs and herbal supplements, due to potential interactions, especially with CYP3A4 inhibitors and oral anticoagulants.
• Alcohol: Limit alcohol consumption as it can increase the risk of liver damage.
• Pregnancy and Breastfeeding: Contraindicated during pregnancy (Category X) and breastfeeding. Women of childbearing potential should use effective contraception.
• Diabetes: Diabetic patients should monitor blood sugar levels regularly as the medicine can slightly increase blood sugar.

Storage Store MACTOR F tablets at room temperature, ideally below 30°C, away from moisture, direct light, and heat. Keep out of sight and reach of children.

What is MACTOR F used for?

MACTOR F is primarily used to treat high levels of lipids (cholesterol and triglycerides) in the blood. It helps reduce "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL). By doing so, it helps prevent serious cardiovascular problems like heart attacks and strokes.

How does MACTOR F work?

MACTOR F is a combination medication containing Atorvastatin and Fenofibrate. Atorvastatin belongs to a class of drugs called statins, which work by blocking an enzyme in the liver responsible for cholesterol production, thereby lowering LDL and triglycerides. Fenofibrate, a fibric acid derivative, increases the breakdown and removal of fats from the bloodstream, leading to reduced triglycerides and increased HDL levels.

What is the usual dosage of MACTOR F?

The typical dosage of MACTOR F is one tablet once daily. Your doctor will determine the exact dose and duration of treatment based on your medical condition and response to the medication. It can be taken with or without food, but it's best to take it at the same time each day for consistency. The tablet should be swallowed whole and not chewed, crushed, or broken.

What are the possible side effects of MACTOR F?

Common side effects can include headache, stomach pain, constipation, joint pain, muscle pain or weakness, back pain, nausea, indigestion, and diarrhea. Most of these side effects are usually temporary and resolve over time. However, if you experience persistent or severe side effects, especially unexplained muscle pain or weakness accompanied by fever, dark-colored urine, or yellowing of the skin, you should contact your doctor immediately.

Is MACTOR F safe during pregnancy or breastfeeding?

No, MACTOR F is considered unsafe and is not recommended for use during pregnancy as it can harm the unborn baby. Women of childbearing potential should use effective contraception to prevent pregnancy while taking this medication. MACTOR F is also contraindicated for breastfeeding women, as it may pass into breast milk and affect the baby.

Can MACTOR F be taken with other medications?

It is crucial to inform your doctor about all other medications, supplements, or herbal products you are currently taking to avoid potential drug interactions. MACTOR F can interact with certain medications, such as blood thinners (e.g., Warfarin, increasing bleeding risk), some antibiotics (e.g., Clarithromycin, Erythromycin), antifungals (e.g., Itraconazole), and other cholesterol-lowering drugs (e.g., Niacin, Gemfibrozil), which can increase the risk of muscle problems or affect the medicine's effectiveness. Immunosuppressants like Cyclosporine can also interact, potentially leading to kidney problems.

What precautions should be taken while on MACTOR F?

Do not take MACTOR F if you are allergic to any of its components or have severe kidney or liver disease, or gallbladder disease. Caution is advised if you have a history of stroke, hypothyroidism, diabetes (blood sugar levels may need monitoring), or a family history of muscle problems. Avoid consuming excessive alcohol, as it can increase the risk of liver damage. Also, avoid large amounts of grapefruit juice, as it can increase the blood levels of the medication. Regular liver function tests may be recommended by your doctor. It is important to follow a healthy diet and exercise regimen along with taking this medicine.

What happens if a dose of MACTOR F is missed?

If you miss a dose of MACTOR F, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should MACTOR F be stored?

MACTOR F tablets should be stored in a cool and dry place, away from direct sunlight, moisture, and heat. Keep the medicine out of the sight and reach of children and pets. The typical storage temperature is below 25°C or 30°C.