Dyamide Plus 10/25

DYAMIDE PLUS 10/25

Name:

• Brand Name: DYAMIDE PLUS 10/25
• Common Name: Spironolactone and Torsemide tablets

Composition:

• Each tablet contains:
  • Torsemide 10 mg
  • Spironolactone 25 mg

Uses: DYAMIDE PLUS 10/25 is a combination medication primarily used as a diuretic ("water pill") to remove excess fluid from the body. It is prescribed for:

• Oedema (Fluid Overload) Management:
  • Associated with congestive heart failure
  • Related to hepatic cirrhosis (chronic liver damage)
  • Due to kidney disease, including nephrotic syndrome
  • Associated with pulmonary hypertension (high blood pressure in the lungs)
  • Reducing swelling in the lower limbs, hands, or abdomen
• Hypertension Treatment:
  • Managing resistant high blood pressure (hypertension)
  • Lowering high blood pressure to reduce the risk of future heart attacks, strokes, or angina
• Heart Disease Support: Alleviating symptoms of fluid overload to support heart disease management
• Primary Hyperaldosteronism: Treating conditions where adrenal glands produce too much aldosterone

Dosage and Administration:

• DYAMIDE PLUS 10/25 should be taken orally as directed by a doctor.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
• It can be taken with or without food, but taking it with food may help reduce symptoms like nausea.
• It is often recommended to take this medicine in the morning to avoid frequent urination at night.
• For consistent results, try to take it at the same time each day.
• Do not stop taking the medicine abruptly, as it may raise blood pressure and increase the risk of heart diseases and stroke.

Side Effects: Common side effects may include:

• Headache
• Dizziness
• Nausea and vomiting
• Diarrhoea
• Fatigue
• Dehydration
• Electrolyte disturbances (e.g., increased potassium (hyperkalemia), decreased sodium, or magnesium levels)
• Increased urination
• Gynaecomastia (enlargement of breast tissue in males)
• Menstrual irregularities in women
• Stomach pain
• Leg cramps

Serious side effects that require medical attention if persistent or worsening include:

• Severe dizziness or fainting
• Signs of high potassium (weakness, lightheadedness, numbness or tingling, heavy legs, weak pulse, irregular heartbeat)
• Very bad allergic reactions (rash, hives, itching, shortness of breath, swelling of face/lips/tongue/throat)

Precautions:

• Allergies: Do not take if allergic to Spironolactone, Torsemide, or any other components of the tablet.
• Kidney/Liver Disease: Use with caution in patients with kidney or liver problems. Close monitoring is required, and dose adjustments may be necessary. It is contraindicated in severe kidney disease (creatinine clearance less than 30 mL/min) and hepatic coma or pre-coma.
• Low Blood Pressure: Not recommended for individuals with low blood pressure (less than 90 mmHg) or cardiogenic shock.
• Pregnancy and Breastfeeding: DYAMIDE PLUS 10/25 should be used with caution during pregnancy and is generally not recommended during breastfeeding as its components may pass into breast milk. Consult a doctor to weigh the potential risks and benefits.
• Electrolyte Imbalance: Dehydration and electrolyte disturbances must be corrected before starting this medicine. Regular monitoring of electrolyte levels is crucial due to the risk of hyperkalemia (high potassium levels).
• Potassium Supplements/Foods: Avoid taking extra potassium supplements or consuming potassium-rich foods (e.g., bananas, broccoli) unless advised by a doctor, as this can lead to excessive potassium levels.
• Alcohol: Avoid or limit alcohol consumption, as it may increase the risk of dehydration, dizziness, and low blood pressure.
• Driving/Operating Machinery: May cause dizziness or drowsiness; therefore, it is advised not to drive or operate machinery if these symptoms occur.
• Diabetes: Use with caution in diabetic patients as it may affect blood sugar levels, requiring closer monitoring.
• Drug Interactions: Inform your doctor about all medications, herbal supplements, and over-the-counter drugs being taken. Notable interactions include:
  • ACE inhibitors (e.g., Captopril, Lisinopril): May cause excessive lowering of blood pressure and increased potassium levels.
  • Lithium: May increase lithium levels, leading to toxicity.
  • NSAIDs (e.g., Indomethacin): May reduce the diuretic effect.
  • Cholestyramine: May reduce the effect of DYAMIDE PLUS 10/25.
  • Other potassium-sparing diuretics (e.g., Amiloride, Eplerenone): Concomitant use is generally not recommended due to increased risk of hyperkalemia.

Storage:

• Store in a cool and dry place, away from direct sunlight, moisture, and heat.
• Keep out of sight and reach of children and pets.
• Store at room temperature (10ºC to 25ºC or below 30ºC).
• Do not use after the expiry date printed on the package.

What is DYAMIDE PLUS 10/25 used for?

DYAMIDE PLUS 10/25 is primarily used to treat oedema (fluid overload or fluid retention) associated with various conditions such as heart failure, liver cirrhosis, kidney disease, and pulmonary hypertension (high blood pressure in the lungs). It is also used to manage resistant hypertension (high blood pressure that doesn't respond well to single medications) and primary hyperaldosteronism. By reducing excess fluid, it helps to alleviate symptoms like swelling in the legs, shortness of breath, and chest pain, and also helps lower high blood pressure.

How does DYAMIDE PLUS 10/25 work?

DYAMIDE PLUS 10/25 is a combination medicine containing Torsemide (10 mg) and Spironolactone (25 mg). Torsemide is a loop diuretic that increases the amount of urine passed from the kidneys, helping to remove excess salt and water from the body. Spironolactone is a potassium-sparing diuretic and an aldosterone antagonist. It works by blocking the action of the hormone aldosterone, which normally causes the body to retain salt and water. By blocking it, spironolactone increases sodium and water excretion while helping the body retain potassium. This combination effectively reduces fluid levels and the workload on the heart, making it more efficient at pumping blood.

What is the usual dosage for DYAMIDE PLUS 10/25?

The dosage of DYAMIDE PLUS 10/25 should be taken exactly as prescribed by your doctor. It can typically be taken orally with or without food, usually once daily in the morning to avoid frequent urination at night. It is important to swallow the tablet whole with a glass of water and not to crush, break, or chew it.

What are the possible side effects of DYAMIDE PLUS 10/25?

Common side effects may include dehydration, electrolyte disturbances (changes in potassium and sodium levels), headache, nausea, dizziness, increased urination, muscle cramps, stomach pain, vomiting, indigestion, diarrhea, and weakness. More serious, though less common, side effects can include hyperkalemia (high potassium levels), which can lead to irregular heartbeats. If side effects persist or worsen, consult your doctor.

Is DYAMIDE PLUS 10/25 safe during pregnancy or breastfeeding?

DYAMIDE PLUS 10/25 should generally be used with caution during pregnancy, and its use should be discussed with a doctor to weigh potential risks and benefits. It is usually not recommended during breastfeeding, as its components may pass into breast milk and could potentially harm the nursing infant. It is advisable to consult your doctor regarding breastfeeding while on this medication.

Can DYAMIDE PLUS 10/25 be taken with other medications?

DYAMIDE PLUS 10/25 can interact with several other medications. It may interact with ACE inhibitors and ARBs (angiotensin receptor blockers), NSAIDs (non-steroidal anti-inflammatory drugs like ibuprofen), cardiac glycosides (like digoxin), potassium supplements, and lithium. Concomitant use with certain antibiotics (such as Streptomycin, Gentamicin, or cephalosporins), cholestyramine, probenecid, or carbenoxolone should be avoided or used with caution. Always inform your doctor about all medications, herbal supplements, and over-the-counter drugs you are taking to avoid potential interactions.

What precautions should be taken while taking DYAMIDE PLUS 10/25?

Avoid consuming alcohol while taking DYAMIDE PLUS 10/25, as it can increase the risk of dizziness and dehydration, and may cause a sudden drop in blood pressure. Exercise caution if you have kidney or liver disease, and your doctor may adjust the dose. Due to the risk of increased potassium levels, avoid potassium-rich foods (like bananas and broccoli) and potassium supplements unless advised by your doctor. This medication may cause dizziness, so refrain from driving or operating machinery until you know how it affects you. Do not stop taking the medication abruptly without consulting your doctor.

What happens if a dose of DYAMIDE PLUS 10/25 is missed?

If you miss a dose of DYAMIDE PLUS 10/25, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should DYAMIDE PLUS 10/25 be stored?

DYAMIDE PLUS 10/25 should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it in its original packaging and out of the sight and reach of children and pets. Do not use the medicine after the expiry date printed on the package.