Nexito Ls

NEXITO LS by SUN PHARMA VV

Name

• Brand Name: NEXITO LS
• Common Name: Nexito LS Tablet

Composition

NEXITO LS Tablet contains a combination of two active ingredients:

• Clonazepam (0.25 mg)
• Escitalopram Oxalate (10 mg)

Uses

NEXITO LS Tablet is primarily prescribed for the management of:

• Comorbid depression and anxiety disorders, addressing symptoms such as excessive worry, fear, sadness, and hopelessness.
• Anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder.
• Symptoms often associated with anxiety and depression, such as restlessness, tension, insomnia, difficulty concentrating, and sleep problems.
• It may also help in controlling panic attacks and can be involved in alleviating Obsessive-Compulsive Disorder (OCD) symptoms.

Dosage and Administration

• NEXITO LS Tablet is typically taken once a day, with or without food.
• It should be swallowed whole with a glass of water and not crushed or chewed.
• The dosage may vary based on individual factors like the severity of the condition and response to treatment, and should always be followed as prescribed by a doctor.
• It is important to take the medicine at the same time each day to maintain consistent levels in the body.
• Do not suddenly stop taking this medicine, as it can lead to withdrawal symptoms; dosage reduction should be gradual under medical guidance.

Side Effects

Common side effects of NEXITO LS Tablet may include:

• Drowsiness, excessive tiredness, or sleepiness.
• Nausea.
• Confusion.
• Problems with coordination or uncoordinated body movements.
• Difficulty falling asleep (insomnia).
• Headache.
• Dizziness.
• Fatigue.
• Stomach upset/diarrhea.
• Decreased libido (low sexual desire) or delayed ejaculation in males.
• Memory impairment.
• Dry mouth, increased or decreased appetite, increased sweating.

Precautions

• Allergy: Do not take NEXITO LS if you are allergic to escitalopram, clonazepam, other SSRIs, or benzodiazepines.
• Pregnancy: NEXITO LS Tablet is not recommended during pregnancy due to potential risks of fetal harm and should only be used if clearly advised by a doctor.
• Breastfeeding: It is generally considered unsafe during breastfeeding, as it may pass into breast milk and harm the baby.
• Alcohol: Avoid consuming alcohol while taking this medicine, as it can increase the risk of side effects like drowsiness and dizziness.
• Driving & Operating Machinery: NEXITO LS can cause dizziness and drowsiness, affecting mental and physical abilities; avoid driving or operating machinery until you know how the medication affects you.
• Liver & Kidney Conditions: Use with caution in patients with liver disease or severe kidney disease, as dose adjustments may be required.
• Other Medical Conditions: Caution is advised for patients with a history of seizures, heart problems, low blood sodium levels, manic-depressive illness, bleeding disorders, diabetes, or certain respiratory conditions.
• Suicidal Tendencies: This medicine may cause suicidal behavior, especially with prolonged use. Patients should be monitored for changes in mood or behavior.
• Drug Interactions: Inform your doctor about all other medications, including antidepressants, antipsychotics, blood thinners (e.g., Warfarin), NSAIDs (e.g., Aspirin, Ibuprofen), stimulant drugs, certain antibiotics, antifungals, heartburn medications (e.g., Cimetidine), and other sleep-inducing medicines, as interactions can occur.
• Children: NEXITO LS is not recommended for individuals below 18 years of age due to unestablished safety and efficacy.

Storage

• Store NEXITO LS Tablet at a temperature below 30ºC, in a cool and dry place.
• Protect it from light and moisture.
• Keep out of sight and reach of children and pets.
• Do not use the medicine after the expiry date.

What is Nexito LS used for?

Nexito LS Tablet is a prescription medicine primarily used for the management of comorbid depression and anxiety disorder, which is when a person experiences both anxiety and depression simultaneously. It is also used to treat generalized anxiety disorder, social anxiety disorder, panic disorder, and obsessive-compulsive disorder (OCD). The medication helps alleviate symptoms such as excessive worry, fear, tension, sadness, and hopelessness, and can also improve sleep quality.

How does Nexito LS work?

Nexito LS is a combination of two active ingredients: Clonazepam and Escitalopram. Clonazepam is a benzodiazepine that works by increasing the action of gamma-aminobutyric acid (GABA), a chemical messenger in the brain that suppresses abnormal nerve cell activity, leading to a calming effect and reduced anxiety and panic attacks. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases the levels of serotonin, a natural substance in the brain responsible for regulating mood, emotions, and sleep, thereby improving mood and reducing anxiety symptoms.

What is the usual dosage of Nexito LS?

Nexito LS Tablet should be taken orally exactly as prescribed by your doctor. It is typically taken once daily, with or without food, preferably at the same time each day to maintain consistent blood levels. The specific dosage and duration of treatment will depend on your individual medical condition, its severity, and your response to the medication. It is crucial not to change the dose or stop taking the medication without consulting your doctor.

What are the possible side effects of Nexito LS?

Common side effects of Nexito LS can include nausea, headache, blocked or runny nose, increased or decreased appetite, restlessness, anxiety, abnormal dreams, difficulties falling asleep or feeling excessively sleepy, dizziness, tremors, yawning, prickling of the skin, diarrhea, constipation, vomiting, dry mouth, increased sweating, muscle and joint pain, and sexual problems (such as problems with erection, delayed ejaculation, decreased sexual drive, and difficulties achieving orgasm in women). Other potential side effects include fatigue, fever, increased weight, confusion, memory impairment, and uncoordinated body movements.

Is Nexito LS safe during pregnancy or breastfeeding?

Pregnancy: Nexito LS is generally considered unsafe for use during pregnancy, as there is definite evidence of risk to the developing baby. If taken in the third trimester, it may cause issues in the newborn such as breathing difficulties, body temperature changes, bluish skin, fits, feeding difficulties, and stiff or floppy muscles. It should only be used if clearly necessary and if the potential benefits are considered to outweigh the risks by your doctor.

Breastfeeding: Nexito LS is probably unsafe to use during breastfeeding or should be used with caution. Your doctor may advise you to stop breastfeeding while taking this medication. Always consult your doctor for a thorough risk-benefit assessment.

Can Nexito LS be taken with other medications?

Nexito LS can interact with various medications. It should not be taken with MAO inhibitors (e.g., phenelzine, isocarboxazid, moclobemide), selegiline, linezolid, or alcohol.

Inform your doctor if you are taking blood thinners (like warfarin), stimulant drugs, NSAIDs (e.g., aspirin, ibuprofen), other anxiety medications (e.g., buspirone), seizure medications (e.g., carbamazepine), heartburn medications (e.g., cimetidine), diuretics, other antidepressants (including herbal remedies like St. John's Wort), pain medications (e.g., tramadol), lithium, antipsychotics (e.g., risperidone), tryptophan, antifungal medicines, certain antibiotics (e.g., erythromycin), asthma medications, or other sleep-inducing medicines. Taking Nexito LS with other drugs that cause sleepiness can worsen this effect.

What precautions should be taken while taking Nexito LS?

It is important to avoid alcohol consumption while taking Nexito LS, as it can increase the sedative effects. This medicine is not recommended for children and adolescents (18 years and below) and should be used with caution in elderly patients (above 65 years of age).

Exercise caution if you have liver disease, kidney dysfunction, heart problems (including abnormal heart rhythm), acute narrow-angle glaucoma, epilepsy, diabetes, bleeding or bruising disorders, or a history of suicidal thoughts. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause drowsiness, dizziness, or sudden sleep. Abruptly stopping Nexito LS can lead to withdrawal symptoms, so always follow your doctor's guidance for discontinuation.

What happens if a dose of Nexito LS is missed?

If you miss a dose of Nexito LS, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should Nexito LS be stored?

Nexito LS Tablet should be stored at room temperature, ideally not exceeding 30°C. Keep it in a tightly closed container, away from excess heat and moisture (it should not be stored in the bathroom). Always ensure it is kept out of reach of children and pets.