Presidio Tablet (10 Tab)

PRESIDIO TABLET (10 TAB) by AJANTA PHARMA LIMITED

Name

• Brand Name: Presidio Tablet
• Common Name: Etoricoxib and Pregabalin Tablets

Composition

Each tablet contains:

• Etoricoxib: 60 mg
• Pregabalin: 75 mg

Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking the COX-2 enzyme, thereby reducing inflammation and pain. Pregabalin is an anticonvulsant that affects nerve signals to alleviate nerve pain and control seizures.

Uses

Presidio Tablet is prescribed for the management of various pain and inflammatory conditions, including:

• Neuropathic pain due to nerve damage or dysfunction, such as painful diabetic neuropathy and pain caused by spinal cord injury or shingles
• Pain and inflammation associated with arthritis and gout
• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Fibromyalgia
• Certain types of seizures

Dosage and Administration

Presidio Tablet is typically taken orally, with or without food. It is important to swallow the tablet whole with a glass of water, without crushing, chewing, or dissolving it.

• Typical Guidance: Etoricoxib is usually administered once daily, and Pregabalin is taken two to three times a day. The exact dosage and duration depend on the condition, severity, and patient's response, as directed by a healthcare professional.
• Missed Dose: If a dose is missed, it should be taken as soon as remembered, unless it's almost time for the next dose. Do not double the dose.

Side Effects

Common side effects may include:

• Dizziness
• Sleepiness/Drowsiness
• Stomach pain/Abdominal pain
• Nausea
• Diarrhea
• Swelling of the legs or feet (oedema)
• Headache
• Fatigue
• Dryness in mouth
• Blurred vision
• Weight gain
• Impaired concentration

Serious side effects, though less common, can include:

• High blood pressure and heart problems
• Allergic reactions (e.g., swelling of the face, mouth, or neck, skin rashes)
• Mood changes
• Changes in liver function tests

Precautions

• Contraindications: Should not be used by individuals with severe heart failure, active stomach ulcers, or known allergies to etoricoxib, pregabalin, or similar NSAIDs (e.g., aspirin, ibuprofen).
• Heart/Kidney/Liver Conditions: Caution is advised for patients with a history of heart, kidney, or liver problems. Etoricoxib can increase cardiovascular risk, and both components should be used carefully in patients with kidney problems.
• Substance Abuse History: Caution is advised for those with a history of substance abuse due to the habit-forming potential of Pregabalin.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding due to potential risks to the baby; consult a doctor.
• Alcohol Interaction: Avoid alcohol consumption as it can enhance side effects like dizziness and drowsiness and may increase the risk of liver damage.
• Driving and Operating Machinery: May cause dizziness, sleepiness, or blurred vision, so caution is advised when driving or operating machinery.
• Drug Interactions:
  • Etoricoxib can interact with blood thinners (e.g., warfarin) and other NSAIDs, increasing the risk of bleeding or stomach ulcers.
  • Pregabalin can interact with medications that cause drowsiness (e.g., opioids, benzodiazepines), leading to increased sedation.
  • Inform your doctor about all other medicines, including herbal tonics and supplements.

Storage

Store Presidio Tablet at room temperature (20-25°C), away from direct sunlight and moisture. Keep it out of reach of children and pets.

PRESIDIO TABLET is a combination medication containing Etoricoxib and Pregabalin, used primarily for managing neuropathic pain and other inflammatory conditions. It is manufactured by Ajanta Pharma Limited.

What is PRESIDIO TABLET used for?

PRESIDIO TABLET is primarily used to treat neuropathic pain, which is pain caused by nerve damage. This includes conditions such as painful diabetic neuropathy, post-herpetic neuralgia (pain after shingles), and pain associated with spinal cord injury. It is also used to manage fibromyalgia, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and certain types of seizures.

How does PRESIDIO TABLET work?

PRESIDIO TABLET contains two active ingredients: Etoricoxib and Pregabalin. Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking the release of specific chemical messengers (prostaglandins) in the brain responsible for causing pain, redness, and swelling. Pregabalin is an anticonvulsant that affects chemicals in the brain responsible for sending pain signals across the nervous system, helping to relieve nerve pain by binding to specific sites on voltage-gated calcium channels.

What is the usual dosage for PRESIDIO TABLET?

The dosage of PRESIDIO TABLET will be determined by your doctor based on your medical condition and response to treatment. It should be taken orally with water, with or without food, as directed by your doctor. It is important to swallow the tablet whole and not to chew, crush, or break it. To get the most benefit, try to take your medicine at the same time each day, and do not increase your dose without consulting your doctor. Your doctor may start you on a low dose and gradually increase it.

What are the possible side effects of PRESIDIO TABLET?

Common side effects of PRESIDIO TABLET may include dizziness, headache, sleepiness (somnolence), dry mouth, nausea, vomiting, stomach pain, swelling (oedema) of the ankles or feet, blurred vision, weight gain, fatigue, indigestion (dyspepsia), and diarrhoea. If any of these side effects worsen or persist, you should consult your doctor.

Is PRESIDIO TABLET safe during pregnancy or breastfeeding?

PRESIDIO TABLET is generally not recommended for use during pregnancy unless specifically prescribed by a doctor who has assessed the potential benefits against the risks to the fetus. Women who are able to become pregnant should use effective birth control methods during treatment. It is also advisable to avoid PRESIDIO TABLET while breastfeeding, as its safety during lactation is not well-established, and the medicine passes into human breast milk. Always consult your doctor for personalized advice.

Can PRESIDIO TABLET be taken with other medications?

PRESIDIO TABLET may interact with certain medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions. Particular care should be taken if you are using blood thinners (e.g., warfarin, low-dose aspirin), medicines for high blood pressure (e.g., furosemide, ramipril, losartan), other pain relievers (especially other NSAIDs), antiepileptic drugs, medicines for immune system alteration (e.g., cyclosporine, tacrolimus), mental disorders (e.g., lithium), cancer (e.g., methotrexate), or hormonal contraceptives.

What precautions should be taken while using PRESIDIO TABLET?

Avoid consuming alcohol while taking PRESIDIO TABLET as it can enhance side effects like dizziness and drowsiness and may increase the risk of liver damage. Due to potential dizziness, drowsiness, or blurred vision, avoid driving or operating heavy machinery until you know how the medication affects you. Caution is advised for elderly patients and those with a history of heart disease, liver disease, kidney problems, gastrointestinal ulcers, or uncontrolled high blood pressure. Do not stop taking the medication abruptly without consulting your doctor, as this could lead to withdrawal symptoms or a worsening of your condition.

What happens if a dose of PRESIDIO TABLET is missed?

If you miss a dose of PRESIDIO TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. If you have concerns about missed doses, consult your doctor.

How should PRESIDIO TABLET be stored?

PRESIDIO TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. The ideal storage temperature is generally below 30°C (or between 20-25°C). Keep the medicine out of the reach and sight of children.