Telista Trio Cl 6.25 Mg Tablet (10 Tab)

TELISTA TRIO CL 6.25 MG TABLET

TELISTA TRIO CL 6.25 MG TABLET, manufactured by LUPIN LTD., is a combination medication primarily used for the management of hypertension (high blood pressure). This medication is prescribed when blood pressure cannot be effectively controlled by a single antihypertensive agent. By lowering high blood pressure, it helps reduce the risk of associated cardiovascular complications such as heart attacks, strokes, and kidney issues.

Composition

Each tablet contains a fixed-dose combination of three active ingredients:

• Telmisartan: 40 mg (an angiotensin II receptor blocker that relaxes and widens blood vessels)
• Cilnidipine: 10 mg (a calcium channel blocker that relaxes blood vessel walls and improves blood flow)
• Chlorthalidone: 6.25 mg (a thiazide-like diuretic that increases the elimination of excess water and sodium from the body)

Uses

TELISTA TRIO CL 6.25 MG TABLET is used for:

• Treatment of essential hypertension (high blood pressure in adults).
• Management of hypertension when a single medication is insufficient to control blood pressure.
• Reducing the risk of heart attacks, strokes, and kidney problems associated with high blood pressure.

Dosage and Administration

This medicine should be taken orally, as directed by a physician. It is usually taken once daily, with or without food. It is crucial to take it at the same time each day to maintain effectiveness. Due to its diuretic component, it is advisable to avoid taking it within four hours of bedtime to prevent increased urination disrupting sleep. The dosage may vary based on the patient's condition and response to the medication. Do not stop taking the medicine without consulting your doctor, even if you feel better, as high blood pressure often has no symptoms.

Side Effects

Common side effects may include:

• Ankle swelling
• Headache
• Dizziness
• Tiredness/Fatigue
• Nausea, upset stomach, or diarrhea
• Palpitations
• Sleepiness
• Taste changes
• Increased blood uric acid levels
• Glucose intolerance
• Flushing (feeling of warmth in the face, ears, neck, and trunk)

Serious side effects, though less common, warrant immediate medical attention.

Precautions

• Pregnancy and Breastfeeding: Not recommended during the second and third trimesters of pregnancy due to potential harm to the unborn baby. It is also not recommended for use by breastfeeding women.
• Liver and Kidney Issues: Use with caution in patients with liver or kidney problems; severe liver or kidney disease may contraindicate its use.
• Electrolyte Imbalances: May cause low sodium or potassium levels and hypochloremic alkalosis. Regular monitoring of serum electrolytes is necessary.
• Alcohol: Avoid or limit alcohol consumption as it may increase the risk of low blood pressure and dizziness.
• Drug Interactions: Inform your doctor about all medications, supplements, and herbal products being taken, especially NSAIDs, lithium, cardiac glycosides (like digoxin), and CYP3A4 inhibitors, as interactions can occur.
• Grapefruit Juice: Avoid consuming grapefruit or grapefruit juice, as it can increase the body's exposure to cilnidipine.
• Children: Not recommended for individuals under 18 years of age.

Storage

Store in a cool and dry place, away from direct sunlight. Keep out of reach and sight of children. The recommended storage temperature is below 30°C or between 10ºC to 25ºC.

What is Telista Trio CL 6.25 mg Tablet used for?

Telista Trio CL 6.25 mg Tablet is primarily used to treat hypertension (high blood pressure). It is often prescribed when a single medication is not sufficient to control blood pressure effectively. By lowering high blood pressure, this medicine helps to reduce the risk of future heart attacks, strokes, and kidney problems.

How does Telista Trio CL 6.25 mg Tablet work?

Telista Trio CL 6.25 mg Tablet is a combination of three active ingredients: Telmisartan (40mg), Cilnidipine (10mg), and Chlorthalidone (6.25mg).

• Telmisartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of a hormone called angiotensin II, which narrows blood vessels. By blocking this hormone, Telmisartan helps to relax and widen blood vessels, thereby lowering blood pressure.
• Cilnidipine is a calcium channel blocker. It works by preventing calcium from entering the muscle cells of the blood vessels, causing them to relax and widen. This helps improve blood flow and oxygen supply to the heart.
• Chlorthalidone is a thiazide-like diuretic (a water pill). It works by increasing the removal of excess water, sodium, and potassium from the body through urine. This reduces the volume of fluid circulating through blood vessels, which helps lower blood pressure.

What is the usual dosage for Telista Trio CL 6.25 mg Tablet?

The usual dosage of Telista Trio CL 6.25 mg Tablet is typically one tablet once daily, taken orally. It can be taken with or without food. The exact dosage and duration of treatment will be determined by your doctor based on your specific condition and response to the medicine. It is important to take it consistently at the same time each day for the best results and not to alter the prescribed dosage without consulting your doctor.

What are the possible side effects of Telista Trio CL 6.25 mg Tablet?

Common side effects of Telista Trio CL 6.25 mg Tablet may include ankle swelling, headache, dizziness, tiredness, nausea, fatigue, and changes in taste. Other reported side effects include palpitations, sleepiness, increased blood uric acid levels, glucose intolerance, flushing, upset stomach, altered blood lipid levels, diarrhoea, muscle spasms, and increased urination. Most side effects are temporary and resolve over time. If any side effects persist or worsen, it is important to consult your doctor.

Is Telista Trio CL 6.25 mg Tablet safe during pregnancy or breastfeeding?

Telista Trio CL 6.25 mg Tablet is generally not recommended during pregnancy, especially during the second and third trimesters, as it may cause harm to the fetus. For breastfeeding women, limited safety data is available, and it is advised to avoid taking this medicine and consult a doctor for safer alternatives, as it may be excreted in human milk and harm the baby.

Can Telista Trio CL 6.25 mg Tablet be taken with other medications or foods?

It is crucial to inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential drug interactions.

• Drug-Drug Interactions: Medications like NSAIDs (e.g., ibuprofen) can reduce the blood pressure-lowering effect and increase the risk of kidney problems. Lithium, cardiac glycosides (like digoxin), and CYP3A4 inhibitors (like clarithromycin) can also interact with components of Telista Trio CL 6.25 mg Tablet.
• Drug-Food Interactions: Consumption of grapefruit or grapefruit juice should be avoided as it can increase the exposure to cilnidipine. Drinking alcohol can also lower blood pressure and may exaggerate side effects. High-sodium foods can increase the risk of dehydration and electrolyte imbalances.

What precautions should be taken while taking Telista Trio CL 6.25 mg Tablet?

• Inform your doctor about any liver or kidney problems, heart conditions, diabetes, gout, or electrolyte imbalances (e.g., low sodium or potassium levels) before starting this medication.
• Regular monitoring of blood pressure, kidney function, electrolyte levels, and blood sugar is recommended.
• As the medication contains a diuretic, it may increase urination; therefore, it's advisable to avoid taking it within four hours of bedtime.
• Stay hydrated to mitigate potential side effects like muscle weakness, dry mouth, and extreme thirst.
• Avoid driving or operating machinery if you experience dizziness or tiredness.
• Do not stop taking the medication without consulting your doctor, as discontinuing it abruptly can elevate the risk of heart attack or stroke.

What happens if a dose is missed?

If you miss a dose of Telista Trio CL 6.25 mg Tablet, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Telista Trio CL 6.25 mg Tablet be stored?

Telista Trio CL 6.25 mg Tablet should be stored at room temperature, ideally around 25°C, in a clean and dry place. Protect it from excessive heat, moisture, and direct sunlight. Always keep the medicine in a safe place, out of reach of children and pets, and ensure it is used before its expiry date.