Glucreta S (10 + 100)

GLUCRETA S (10 + 100) Tablet is a combination medicine used in the management of type 2 diabetes mellitus. It helps to control blood sugar levels and can also be used in adults with reduced kidney function for chronic kidney disease.

Name

• Brand Name: GLUCRETA S (10 + 100)
• Manufacturer: Torrent Pharmaceuticals Ltd.

Composition

• Active Ingredients: Dapagliflozin (10 mg) and Sitagliptin (100 mg).
  • Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by increasing glucose excretion through urine, thereby lowering blood sugar levels.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that improves insulin secretion from the pancreas and reduces glucagon production by the liver, which decreases glucose levels in the blood.

Uses

GLUCRETA S (10 + 100) Tablet is primarily prescribed for:

• Treatment of type 2 diabetes mellitus in adults, especially when diet and exercise alone are insufficient for blood sugar control.
• Lowering high blood sugar levels and improving the body's response to insulin.
• Management of chronic kidney disease in adults with reduced kidney function.
• May reduce the risk of heart attack, heart failure, or other cardiovascular events.

Dosage and Administration

• Typically, GLUCRETA S (10 + 100) Tablet is taken orally once daily.
• It can be taken with or without food, but it is recommended to take it at the same time each day for consistent results.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• The dosage is determined by your doctor based on your medical condition, blood sugar levels, and response to treatment. Do not stop taking the medication without consulting your doctor.

Side Effects

Common Side Effects:

• Urinary tract infection (UTI)
• Nasal congestion, sore throat, or upper respiratory tract infection
• Headache, dizziness
• Nausea, vomiting, diarrhea, abdominal pain, flatulence, constipation
• Frequent urination
• Genital fungal infections (in both males and females)
• Back pain, joint pain

Serious Side Effects (consult your doctor immediately if experienced):

• Lactic acidosis (a buildup of lactic acid in the blood)
• Allergic reactions (rash, hives, blisters, swelling of lips, tongue, face, or throat, difficulty breathing)
• Pancreatitis (severe and persistent stomach pain that may radiate to the back, with or without nausea and vomiting)
• Diabetic ketoacidosis (increased ketone bodies, nausea, vomiting, stomach ache, excessive thirst, confusion)
• Low blood sugar (hypoglycemia), especially when used with other antidiabetic medicines

Precautions

• Inform your doctor if you have kidney or liver problems, heart disease, a history of pancreatitis, or urinary tract infections.
• Not suitable for individuals with type 1 diabetes mellitus or severe kidney/liver disease.
• Use with caution in pregnant or breastfeeding women; consult your doctor. Dapagliflozin is contraindicated in the second and third trimesters of pregnancy.
• Inform your doctor about all other medications, including prescription, over-the-counter, and herbal supplements, as they may interact with GLUCRETA S.
• Avoid excessive alcohol intake as it can interfere with the medicine's effectiveness and affect blood sugar levels.
• Maintain good hygiene to prevent genital fungal and urinary tract infections.
• Drink plenty of fluids to prevent dehydration.
• Monitor blood sugar levels regularly as directed by your doctor.

Storage

• Store GLUCRETA S (10 + 100) Tablet at room temperature, ideally below 30°C.
• Keep it in a cool, dry place, away from moisture, heat, and direct sunlight.
• Keep out of reach of children and pets.

GLUCRETA S (10 + 100) is a medication manufactured by Torrent Pharmaceuticals Ltd. used for the management of type 2 diabetes mellitus. It combines two active ingredients, Dapagliflozin (10mg) and Sitagliptin (100mg), to help control blood sugar levels.

Here are some frequently asked questions about GLUCRETA S (10 + 100):

What is GLUCRETA S (10 + 100) used for?

GLUCRETA S (10 + 100) is used to manage type 2 diabetes mellitus in adults whose blood sugar levels are not adequately controlled by diet and exercise alone. It can be used as part of a comprehensive treatment plan that includes dietary changes, regular physical activity, and other prescribed diabetes medications, such as metformin, sulfonylureas, or insulin. This medication also helps reduce the risk of cardiovascular events like heart attack and heart failure in patients with type 2 diabetes.

How does GLUCRETA S (10 + 100) work?

GLUCRETA S (10 + 100) contains a combination of two active substances: Dapagliflozin and Sitagliptin.

• Dapagliflozin (10mg) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking a specific protein in the kidneys responsible for reabsorbing glucose (sugar) back into the blood. This action leads to increased removal of sugar through the urine, thereby reducing blood sugar levels.
• Sitagliptin (100mg) is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It indirectly increases the activity of certain natural chemicals in the body called incretin hormones. These hormones stimulate the pancreas to release more insulin after a meal and decrease the amount of glucagon (a hormone that raises blood sugar) produced by the liver, thus lowering blood sugar levels.

What is the usual dosage for GLUCRETA S (10 + 100)?

GLUCRETA S (10 + 100) should be taken exactly as prescribed by your doctor. It is typically taken once daily, and can be consumed with or without food. For optimal benefits and consistent blood sugar control, it's recommended to take the medicine at the same time each day. Do not alter your dosage or stop taking the medication without consulting your doctor, as this could lead to increased blood sugar levels and potential complications.

What are the possible side effects of GLUCRETA S (10 + 100)?

Common side effects of GLUCRETA S (10 + 100) include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, headache, diarrhea, nausea, back pain, and joint pain. Some individuals may also experience fungal infections in the genital area. Drinking plenty of fluids is important to prevent dehydration, which can be a side effect. Rarely, more serious side effects such as lactic acidosis or acute pancreatitis can occur. If you experience symptoms of low blood sugar (hypoglycemia) like cold sweats, pale skin, tremor, or anxiety, especially when taking other anti-diabetic medicines or consuming alcohol, carry a sugary food or fruit juice.

Is GLUCRETA S (10 + 100) safe during pregnancy or breastfeeding?

During Pregnancy: There is limited information on the effects of GLUCRETA S (10 + 100) in pregnant women. Therefore, it is generally not recommended for use during pregnancy, especially as one of its active ingredients, dapagliflozin, is contraindicated in the second and third trimesters. It is crucial to inform your doctor if you are pregnant or planning to become pregnant before starting this medication.

During Breastfeeding: Information regarding whether GLUCRETA S (10 + 100) passes into human breast milk is not available. Hence, this medicine should not be used by breastfeeding women. Always consult your doctor if you are breastfeeding or lactating.

Can GLUCRETA S (10 + 100) be taken with other medications?

It is essential to inform your doctor about all other medicines, herbal products, or supplements you are currently taking or might take, as they can interact with GLUCRETA S (10 + 100). Particular caution should be exercised with:

• Diuretics (water pills) like furosemide or hydrochlorothiazide, as they may increase the risk of dehydration and low blood pressure.
• Insulin or insulin secretagogues (e.g., glipizide, glimepiride) which can increase the risk of low blood sugar (hypoglycemia), potentially requiring a lower dose of these medications.
• Certain antibiotics, antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir), immunosuppressants (e.g., ciclosporin), and cardiac glycosides (e.g., digoxin), as they may interact with GLUCRETA S (10 + 100).
• Oral contraceptives can also affect blood glucose levels and potentially reduce the efficacy of GLUCRETA S.

What precautions should be taken while using GLUCRETA S (10 + 100)?

Before taking GLUCRETA S (10 + 100), inform your doctor if you have any kidney or liver problems, a history of urinary tract infections, heart disease, pancreatitis, gallstones, alcohol dependence, very high triglyceride levels, or a history of low blood pressure, or if you are elderly. This medicine is not suitable for individuals with type 1 diabetes mellitus or diabetic ketoacidosis. It's important to avoid excessive alcohol consumption, as it can interfere with the medicine's effectiveness and affect blood sugar levels. Maintain good personal hygiene to help prevent genital fungal infections. Regular monitoring of blood sugar levels is crucial during treatment.

What happens if a dose of GLUCRETA S (10 + 100) is missed?

If you miss a dose of GLUCRETA S (10 + 100), take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should GLUCRETA S (10 + 100) be stored?

Store GLUCRETA S (10 + 100) in a cool and dry place below 30°C, away from direct sunlight and moisture. Keep this medicine out of the sight and reach of children and pets.