Aprezo 30 Mg Tablet

APREZO 30 MG TABLET

APREZO 30 MG TABLET, manufactured by GLENMARK PHARMACEUTICALS LTD, is a medication used for treating inflammatory conditions.

• Name:

  • Brand Name: Aprezo 30 mg Tablet
  • Common Name: Apremilast

• Composition:

  • Each tablet contains 30 mg of Apremilast as the active ingredient. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that works by blocking certain chemical messengers responsible for inflammation, thereby reducing the signs and symptoms of inflammatory conditions.

• Uses: APREZO 30 MG TABLET is prescribed for the management of:

  • Moderate to severe plaque psoriasis, a chronic skin condition characterized by red, scaly, itchy, and painful patches on the skin.
  • Active psoriatic arthritis, a type of arthritis that affects individuals with psoriasis, causing joint inflammation and pain.
  • Oral ulcers associated with Behcet's disease, a rare inflammatory condition.

• Dosage and Administration:

  • APREZO 30 MG TABLET is taken orally. Tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken.
  • It can be taken with or without food.
  • The typical dosage usually starts low and is gradually increased over the first 6 days to a recommended maintenance dose of 30 mg twice daily. It may take several months for the full effectiveness of the medicine to show.

• Side Effects:

  • Common: Nausea, diarrhea, vomiting, headache, stomach pain, loss of appetite, indigestion/heartburn, upper respiratory tract infection, back pain, and sleep disturbances (insomnia). These are usually mild and may subside as the body adjusts.
  • Serious: Worsening of depression or suicidal thoughts, and significant unintended weight loss.

• Precautions:

  • Pregnancy: Generally not recommended; consult a doctor if pregnant or planning pregnancy.
  • Breastfeeding: Not recommended as it may pass into breast milk.
  • Alcohol: Exercise caution and consult your doctor.
  • Kidney/Liver Problems: Use with caution; dose adjustments may be necessary, especially for severe kidney impairment.
  • Depression/Suicidal Thoughts: Use with caution as it may exacerbate these conditions.
  • Drug Interactions: Inform your doctor about all other medications, including Rifampicin, Phenytoin, Phenobarbital, Carbamazepine, and St. John's Wort, as they may reduce Apremilast's effectiveness. Avoid grapefruit and grapefruit juice.
  • Children and Adolescents: Not recommended for individuals under 17 or 18 years of age.

• Storage:

  • Store in a cool and dry place below 30°C.
  • Protect from sunlight and moisture.
  • Keep out of reach of children.

APREZO 30 MG TABLET is a medication primarily used to treat certain inflammatory conditions. Here are some frequently asked questions about it:

What is Aprezo 30 MG Tablet used for?

APREZO 30 MG Tablet is used to treat psoriatic arthritis, a type of arthritis that affects some people with psoriasis, characterized by joint pain, stiffness, and swelling. It is also prescribed for moderate to severe plaque psoriasis, a skin condition causing red, scaly, itchy, and painful patches on the skin. Additionally, it can be used for oral ulcers associated with Behçet's disease, a rare inflammatory condition.

How does Aprezo 30 MG Tablet work?

APREZO 30 MG Tablet contains apremilast, which is a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking the activity of PDE4, an enzyme responsible for inflammation in the body. By reducing inflammation, it helps to alleviate the signs and symptoms of psoriatic arthritis, plaque psoriasis, and oral ulcers. This action helps regulate the immune response and decreases pro-inflammatory factors.

What is the usual dosage of Aprezo 30 MG Tablet?

Aprezo 30 MG Tablet is typically taken orally, usually twice a day, with or without food, as directed by your doctor. The dosage is often gradually increased over the first 5 to 6 days to help reduce gastrointestinal side effects. After the initial titration, the recommended maintenance dosage is 30 mg twice daily. It's important to swallow the tablet whole and not crush, chew, or break it.

What are the possible side effects?

Common side effects of Aprezo 30 MG Tablet include diarrhea, nausea, vomiting, headache, and upper respiratory tract infection. Other possible side effects can include indigestion, back pain, feeling tired, stomach pain, loss of appetite, and difficulty sleeping. These side effects are usually mild and may subside as your body adjusts to the medication. If they persist or worsen, consult your doctor.

Is it safe during pregnancy or breastfeeding?

APREZO 30 MG Tablet is generally not recommended during pregnancy as it may be unsafe and has shown harmful effects on developing babies in animal studies. Women of childbearing age should discuss birth control methods with their physician. It is also not recommended for use during breastfeeding, as it is not known whether the medicine passes into breast milk and may harm the newborn baby.

Can it be taken with other medications?

Aprezo 30 MG Tablet can interact with certain medications. It is not recommended with strong cytochrome P450 enzyme inducers such as rifampicin (for tuberculosis), phenytoin, phenobarbital, and carbamazepine (for epilepsy/fits), and the herbal medicine St. John's Wort, as these can decrease the effectiveness of Aprezo. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken?

Inform your doctor if you have severe kidney problems, as your dose may need to be adjusted. Exercise caution if you have a history of depression or suicidal thoughts, as Aprezo may worsen these conditions, and your doctor should be informed immediately about any mood changes. Also, tell your doctor if you are underweight, have gut problems, or an intolerance to certain sugars. Regular weight monitoring is recommended as the medicine may cause weight loss. Avoid consuming grapefruit or grapefruit juice, as it can increase the concentration of the medication.

What happens if a dose is missed?

If you miss a dose of Aprezo 30 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Aprezo 30 MG Tablet should be stored in a cool and dry place, typically below 30°C, away from direct sunlight and moisture. Keep it out of sight and reach of children.