Sitazit Dm Er 500/10

SITAZIT DM ER 500/10 Tablet

SITAZIT DM ER 500/10 is an extended-release oral antidiabetic medication manufactured by Glenmark Pharmaceuticals Ltd., used for the comprehensive management of Type 2 Diabetes Mellitus in adults.

• Composition

  • Dapagliflozin: 10 mg
  • Metformin: 500 mg
  • Sitagliptin: 100 mg

• Uses SITAZIT DM ER 500/10 is prescribed for adults with Type 2 Diabetes Mellitus to improve glycemic control. It is particularly indicated when diet, exercise, and therapy with metformin alone or dual therapy with metformin and either dapagliflozin or sitagliptin do not provide adequate blood sugar control. Additionally, it can assist in weight management and help reduce cardiovascular risk. The medicine works by promoting glucose excretion through urine, enhancing insulin release, and reducing glucose production in the liver.

• Dosage and Administration This medicine should be taken exactly as advised by your doctor. It can be taken with or without food, though taking it with meals may help reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water and not crushed, broken, or chewed. For optimal benefits, it is recommended to take it at the same time each day.

• Side Effects

  • Common Side Effects: Genital infections, common cold, diarrhea, headache, nausea, influenza, back pain, cough, vomiting, abdominal pain, flatulence, nasopharyngitis, urinary tract infection, increased or frequent urination, drowsiness, dizziness, constipation, stomach pain, itching, dry mouth, decreased weight, and thirst.
  • Serious Side Effects: Seek immediate medical attention if you experience signs of lactic acidosis (e.g., weakness, breathing difficulty, stomach pain), ketoacidosis (e.g., nausea, vomiting, confusion, fruity breath), painful or persistent genital/urinary infections, pancreatitis (severe stomach pain, nausea), or allergic reactions (e.g., rash, swelling, breathing problems).

• Precautions SITAZIT DM ER 500/10 is contraindicated in patients with severe kidney impairment, end-stage renal disease (ESRD), Type 1 diabetes, acute metabolic acidosis, or severe liver disease. Consult your doctor if you are pregnant or breastfeeding, as the medicine is generally not recommended in these conditions. Alcohol consumption should be avoided as it can increase the risk of lactic acidosis. Caution is advised while driving or operating machinery if the medicine causes dizziness or sleepiness. Inform your doctor about all existing medical conditions and current medications, including diuretics, insulin, beta-blockers, or oral contraceptives, to avoid potential drug interactions.

• Storage Store SITAZIT DM ER 500/10 Tablet at a consistent temperature below 30°C, away from moisture and direct sunlight. Keep the medicine out of the sight and reach of children, and ensure it is used before its expiry date.

What is Sitazit DM ER 500/10 used for?

Sitazit DM ER 500/10 is used to manage Type 2 Diabetes Mellitus in adults. It helps improve blood sugar control when diet and exercise alone, or other single or dual therapies, are insufficient. Additionally, it may aid in weight management and help reduce cardiovascular risk.

How does Sitazit DM ER 500/10 work?

This medicine combines three active ingredients: Dapagliflozin, Sitagliptin, and Metformin. Dapagliflozin (10 mg) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by causing the kidneys to excrete more glucose through urine, thus lowering blood sugar levels. Metformin (500 mg) is a biguanide that reduces glucose production in the liver, decreases glucose absorption from the intestines, and enhances the body's sensitivity to insulin. Sitagliptin (100 mg) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of natural substances called incretin hormones, which help the pancreas release more insulin and reduce the amount of sugar made by the liver when blood sugar is high.

What is the usual dosage of Sitazit DM ER 500/10?

The dosage of Sitazit DM ER 500/10 is determined by your doctor based on your individual health condition. It should be taken exactly as prescribed, typically with or without food at the same time each day. It is important to swallow the tablet whole and not to crush, break, or chew it. Do not stop taking the medicine or change your dose without consulting your doctor.

What are the possible side effects of Sitazit DM ER 500/10?

Common side effects may include genital infections, common cold symptoms (like nasal congestion, sore throat, cough), diarrhea, headache, nausea, back pain, and influenza. More serious, but rare, side effects can include lactic acidosis (signs like weakness, breathing difficulty, or stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), severe genital or urinary infections, pancreatitis, or allergic reactions. Seek immediate medical attention if you experience severe or persistent side effects.

Is Sitazit DM ER 500/10 safe during pregnancy or breastfeeding?

Sitazit DM ER 500/10 is generally not recommended during pregnancy or breastfeeding. It is important to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as some ingredients may pose risks to the baby or affect milk production.

Can Sitazit DM ER 500/10 be taken with other medications?

Sitazit DM ER 500/10 can interact with certain medications. For example, diuretics (water pills) may increase the risk of volume depletion. When taken with insulin or insulin secretagogues (like sulfonylureas), there is an increased risk of low blood sugar (hypoglycemia), which may necessitate a lower dose of these medications. It is crucial to inform your doctor about all other medicines, including prescription, non-prescription, and herbal supplements, you are currently taking.

What precautions should be taken?

Patients with severe kidney impairment, end-stage renal disease, or liver disease should generally avoid this medication due to increased risks like lactic acidosis. Excessive alcohol consumption should be avoided as it can increase the risk of lactic acidosis and hypoglycemia. Regular monitoring of blood sugar levels and kidney function is advisable. Maintain good hygiene to help prevent genital infections.

What happens if a dose is missed?

If you miss a dose of Sitazit DM ER 500/10, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Sitazit DM ER 500/10 should be stored at a consistent temperature below 30°C, away from moisture and direct sunlight. Keep the medicine out of the sight and reach of children, and use it before its expiry date.