Pregeb D 75/30 Mg Capsule (10 Cap)

PREGEB D 75/30 MG CAPSULE

PREGEB D 75/30 MG CAPSULE is a medicine manufactured by Torrent Pharmaceuticals Ltd.

Composition

PREGEB D 75/30 MG CAPSULE contains two active ingredients: Pregabalin 75 mg and Duloxetine 30 mg. Pregabalin is classified as an anticonvulsant, while Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). This combination works by increasing chemical messengers in the brain responsible for regulating pain and by calming overactive nerves.

Uses

This medication is primarily used for the treatment of various types of neuropathic pain and chronic pain conditions. It is prescribed for:

• Diabetic neuropathic pain, which is nerve damage associated with diabetes.
• Fibromyalgia, a chronic condition characterized by widespread muscle pain, tenderness, and fatigue.
• Nerve pain resulting from shingles (postherpetic neuralgia).
• Pain caused by spinal cord injuries. The combination of Pregabalin and Duloxetine aims to provide enhanced pain relief due to their complementary mechanisms of action.

Dosage and Administration

PREGEB D 75/30 MG CAPSULE should be taken exactly as prescribed by a doctor, in the recommended doses and duration. It can be consumed with or without food. Patients may need to wait 2 to 4 weeks before experiencing the full effects of the medicine. It is crucial not to exceed the prescribed dose to avoid an overdose. If discontinuing the medication, the dosage should be reduced gradually under medical supervision to prevent withdrawal symptoms.

Side Effects

Common side effects include:

• Headache, dizziness, and drowsiness.
• Nausea, constipation, diarrhea, and dry mouth.
• Increased sweating, loss of appetite, and weight gain.
• Fatigue, difficulty sleeping, and blurred vision.
• Peripheral edema (swelling of hands, arms, legs, and feet).

Serious side effects, though rare, require immediate medical attention:

• Suicidal thoughts or behavioral changes, new or worsening depression.
• Allergic reactions or angioedema, characterized by skin rash, itching, hives, or swelling of the face, eyes, lips, tongue, or difficulty breathing/swallowing.
• Liver problems, indicated by yellowing of the skin or eyes.
• Low sodium levels (hyponatremia), with symptoms like confusion, headaches, memory problems, or unusual weakness.
• Significant changes in blood pressure, including sudden drops or increases.
• Muscle injury (unusual weakness, muscle pain, dark urine).
• Hallucinations.
• Gastrointestinal bleeding (black or red stool, blood in vomit).
• Respiratory depression (serious breathing problems), particularly if used with narcotic pain medicines.

Precautions

• Alcohol: Avoid consuming alcohol as it can exacerbate drowsiness and increase the risk of liver damage.
• Pregnancy and Breastfeeding: Consult a doctor before use, as it may be unsafe during pregnancy and is probably unsafe during breastfeeding.
• Driving and Machinery: This medicine can cause dizziness, drowsiness, and blurred vision, impairing alertness. Patients should avoid driving or operating heavy machinery until they understand how the medication affects them.
• Kidney and Liver Conditions: Use with caution in patients with kidney disease. It is probably unsafe and should be avoided in patients with liver disease.
• Mental Health: Monitor for any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Report such symptoms to a doctor immediately.
• Discontinuation: Do not stop taking the medicine suddenly without consulting your doctor, as abrupt cessation can worsen the underlying condition or increase the risk of seizures.
• Blood Pressure: Regular monitoring of blood pressure is advised, especially during the initial month of treatment.
• Drug Interactions: Inform your doctor about all other medications you are taking to prevent potential drug interactions.

Storage

Store PREGEB D 75/30 MG CAPSULE in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. The recommended storage temperature is between 10ºC to 25ºC or below 30ºC.

What is PREGEB D 75/30 MG CAPSULE used for?

PREGEB D 75/30 MG CAPSULE is primarily used for the management of neuropathic pain (nerve pain) caused by conditions such as diabetes, spinal cord injury, or fibromyalgia. It is also utilized for widespread musculoskeletal pain and can be part of anxiety disorder management.

How does PREGEB D 75/30 MG CAPSULE work?

This medication combines two active ingredients: Pregabalin and Duloxetine. Pregabalin works by controlling calcium channels in overactive nerve cells, which helps to reduce the transmission of pain signals and alleviate burning, tingling, or stabbing sensations. Duloxetine increases the levels of serotonin and norepinephrine, two chemical messengers in the brain that play a crucial role in regulating mood and pain pathways, thereby reducing stress, anxiety, and pain associated with chronic conditions.

What is the usual dosage for PREGEB D 75/30 MG CAPSULE?

PREGEB D 75/30 MG CAPSULE should be taken exactly as prescribed by your doctor. It can be taken with or without food, but it is important to take it at the same time each day to maintain consistent levels of the medication in your body. The capsule should be swallowed whole with water and not crushed, chewed, or broken. The specific dosage and duration of treatment will be determined by your doctor based on your medical condition and how you respond to the medicine.

What are the possible side effects of PREGEB D 75/30 MG CAPSULE?

Common side effects may include dizziness, drowsiness, dry mouth, weight gain, blurred vision, constipation, headache, nausea, increased appetite, difficulty concentrating, tingling or numbness, and swelling in the limbs (peripheral edema). Less common but potentially more serious side effects can include changes in mood or behavior, including suicidal thoughts, and severe allergic reactions. If you experience any severe or persistent side effects, you should contact your doctor.

Is PREGEB D 75/30 MG CAPSULE safe during pregnancy or breastfeeding?

Using PREGEB D 75/30 MG CAPSULE during pregnancy is generally advised against unless absolutely necessary, as there is limited safety information in humans, and animal studies have indicated potential harm to the developing baby. It is crucial to consult your doctor if you are pregnant, planning to conceive, or become pregnant while taking this medication. The medicine passes into breast milk, so it is recommended to avoid breastfeeding or discuss the potential risks and benefits with your doctor.

Can PREGEB D 75/30 MG CAPSULE be taken with other medications?

It is very important to inform your doctor about all other medications, supplements, and herbal products you are currently taking to avoid potential drug interactions. This medicine can interact with certain other medications, including other antidepressants (like Monoamine Oxidase Inhibitors (MAOIs) or Selective Serotonin Reuptake Inhibitors (SSRIs)), blood thinners (such as aspirin or warfarin), and some antibiotics (like ciprofloxacin). These interactions can either reduce the effectiveness of PREGEB D 75/30 MG CAPSULE or increase the risk of adverse effects. Alcohol and other central nervous system depressants should also be avoided due to the increased risk of drowsiness and dizziness.

What precautions should be taken while taking PREGEB D 75/30 MG CAPSULE?

Do not stop taking PREGEB D 75/30 MG CAPSULE suddenly, as this can lead to withdrawal symptoms or a worsening of your condition; your doctor will advise on a gradual reduction of the dose. Due to potential dizziness and drowsiness, avoid driving or operating heavy machinery until you understand how the medication affects you. Inform your doctor if you have kidney or liver problems, a history of depression, mood changes, suicidal thoughts, glaucoma, heart conditions, or diabetes. It is not recommended for individuals under 18 years of age.

What happens if a dose of PREGEB D 75/30 MG CAPSULE is missed?

If you miss a dose of PREGEB D 75/30 MG CAPSULE, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should PREGEB D 75/30 MG CAPSULE be stored?

Store PREGEB D 75/30 MG CAPSULE in a cool, dry place, away from direct sunlight and moisture. It is crucial to keep the medication out of the sight and reach of children and pets. Do not store this medicine in the bathroom.