Ticavic 90 Tablet

TICAVIC 90 TABLET

TICAVIC 90 TABLET, manufactured by Alkem Laboratories Ltd., is an antiplatelet medication designed to reduce the risk of serious cardiovascular events.

Composition

Each TICAVIC 90 TABLET contains 90 mg of Ticagrelor, which is the active pharmaceutical ingredient. Ticagrelor belongs to a class of drugs called P2Y12 inhibitors (ADP receptor antagonists).

Uses

TICAVIC 90 TABLET is primarily used as a blood thinner to prevent the formation of harmful blood clots in blood vessels. It is prescribed for:

• Prevention of Heart Attack and Stroke: Reducing the risk of future heart attacks and strokes, especially in patients with a history of heart disease or blocked arteries.
• Acute Coronary Syndrome (ACS): Reducing the rate of cardiovascular death, myocardial infarction (heart attack), and stroke in patients with ACS or a history of myocardial infarction.
• Post-Stenting Procedures: Preventing blood clots in stents in patients who have undergone stenting of the heart or percutaneous coronary intervention (PCI) for unstable angina or a recent heart attack.
• Unstable Angina: Management of severe heart-related chest pain.

Dosage and Administration

TICAVIC 90 TABLET should be taken exactly as prescribed by a healthcare professional.

• Typical Dosage: For adults, the recommended initial dose is often 180 mg (two 90 mg tablets), followed by a maintenance dose of 90 mg twice daily. In some cases, after a year, the dose may be reduced to 60 mg twice a day.
• Administration: The tablet can be taken with or without food, but it is advised to take it regularly at the same time each day for best results. Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• Concomitant Therapy: It is often prescribed along with a low dose of aspirin to enhance its protective effect against clot-related events.

Side Effects

As an antiplatelet medicine, TICAVIC 90 TABLET increases the risk of bleeding.

• Common Side Effects: Dyspnea (shortness of breath), bleeding and bruising (which may take longer than usual to stop), headache, dizziness, nausea, diarrhea, indigestion or constipation, skin rash, itching, gout, and low blood pressure.
• Serious Side Effects: Unexpected or severe bleeding (including internal bleeding, pink/red/brown urine, vomiting blood clots, red/black stools), signs of stroke (e.g., sudden numbness or confusion), fainting, or Thrombotic Thrombocytopenic Purpura (characterized by fever and purplish spots on the skin). Seek immediate medical attention if these occur.

Precautions

• Bleeding Risk: TICAVIC 90 TABLET can cause severe bleeding. Inform your doctor if you have any bleeding disorders, a history of bleeding in the brain (intracranial hemorrhage), stomach ulcers, or are scheduled for surgery or dental treatment, as you may be asked to temporarily stop taking the medicine.
• Liver and Kidney Conditions: Caution is advised in patients with liver problems; it is not recommended for those with moderate to severe liver impairment. It is generally considered safe for use in patients with kidney disease, but consult your doctor.
• Pregnancy and Breastfeeding: TICAVIC 90 TABLET is generally not recommended for use during pregnancy or breastfeeding unless necessary, and only after consulting a doctor.
• Alcohol: Avoid excessive alcohol consumption as it can irritate the stomach and increase the risk of stomach ulcers.
• Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements, and vitamins, as Ticagrelor can interact with other blood thinners, NSAIDs, certain antidepressants, antibiotics, antifungals, and other heart medicines.
• Abrupt Discontinuation: Do not stop taking this medicine without consulting your doctor, as this may significantly increase your risk of another heart attack or stroke.

Storage

Store TICAVIC 90 TABLET in a cool and dry place, at a temperature below 30°C. Keep it away from direct sunlight and moisture, and out of the sight and reach of children and pets.

TICAVIC 90 TABLET contains ticagrelor, an antiplatelet medication used to prevent serious cardiovascular events. Below are frequently asked questions about TICAVIC 90 TABLET.

What is TICAVIC 90 TABLET used for?

TICAVIC 90 TABLET, containing ticagrelor, is primarily used to reduce the risk of heart attack, stroke, and cardiovascular death in patients who have experienced an acute coronary syndrome (ACS) or a prior heart attack. It is also used to prevent blood clots in patients with ACS who have received stents in their heart blood vessels. Additionally, it can reduce the risk of a first heart attack or stroke in high-risk patients with coronary artery disease.

How does TICAVIC 90 TABLET work?

TICAVIC 90 TABLET is an antiplatelet medication that works by preventing platelets in your blood from sticking together and forming harmful blood clots. It does this by reversibly blocking the P2Y12 adenosine diphosphate (ADP) receptor on the surface of platelets, which is crucial for platelet activation and aggregation. Unlike some other antiplatelet drugs, ticagrelor does not require metabolic activation by the liver.

What is the usual dosage for TICAVIC 90 TABLET?

The usual initial dose for TICAVIC 90 TABLET is a 180 mg loading dose (two 90 mg tablets taken at the same time). This is typically followed by a maintenance dose of 90 mg twice a day for up to 12 months. In some cases, after one year, your doctor may reduce the dose to 60 mg twice daily. TICAVIC 90 TABLET should always be taken in conjunction with a daily maintenance dose of aspirin, usually 75 mg to 100 mg.

What are the possible side effects of TICAVIC 90 TABLET?

Common side effects can include bleeding more easily than normal (such as nosebleeds, bruising), shortness of breath (dyspnea), headaches, dizziness, and nausea. Other possible side effects include indigestion, diarrhea, and increased levels of uric acid, which can raise the risk of gout. Serious bleeding is a significant potential side effect.

Is TICAVIC 90 TABLET safe during pregnancy or breastfeeding?

TICAVIC 90 TABLET is generally not recommended during pregnancy or if you are trying to conceive due to limited safety information in humans and potential risks observed in animal studies. If you become pregnant while taking this medication, you should contact your doctor immediately. Regarding breastfeeding, it is generally not recommended. While the amount transferred into breast milk is likely low, infants should be monitored for any signs of bruising or bleeding if the mother is taking ticagrelor.

Can TICAVIC 90 TABLET be taken with other medications?

TICAVIC 90 TABLET can interact with many other medications. It is typically taken with a low daily maintenance dose of aspirin (75-100 mg), but higher doses of aspirin (above 100 mg) should be avoided as they may reduce ticagrelor's effectiveness. Avoid taking it with strong CYP3A4 inhibitors like ketoconazole, clarithromycin, and certain HIV medications, as these can increase ticagrelor levels and bleeding risk. Caution is advised with other blood thinners, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, certain statins (e.g., simvastatin, lovastatin), digoxin, and some antidepressants. Always inform your doctor and pharmacist about all medications, supplements, and herbal products you are taking.

What precautions should be taken while taking TICAVIC 90 TABLET?

Due to an increased risk of bleeding, it is very important to inform all medical doctors, dentists, nurses, and pharmacists that you are taking TICAVIC 90 TABLET before any surgery, medical procedures, or dental work. Your doctor may advise you to temporarily stop taking the medication, typically 5 days before a procedure with a major risk of bleeding. You should not take TICAVIC 90 TABLET if you have active pathological bleeding (like a stomach ulcer), a history of bleeding in the brain (intracranial hemorrhage), or severe liver disease. Use with caution if you have moderate liver problems, lung/breathing conditions (like COPD or asthma), or certain heart rhythm disorders. Do not stop taking TICAVIC 90 TABLET suddenly without consulting your doctor, as this can increase your risk of a heart attack or stroke.

What happens if a dose of TICAVIC 90 TABLET is missed?

If you miss a dose of TICAVIC 90 TABLET, you should skip the missed dose and take your next dose at its regularly scheduled time. Do not take a double dose to make up for a missed one.

How should TICAVIC 90 TABLET be stored?

TICAVIC 90 TABLET should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep the medication in a closed container, away from excess heat and moisture (do not store it in the bathroom). Always ensure it is kept out of sight and reach of children.