Istamet D Xr 1000 Mg Tablet (7 Tab)

ISTAMET D XR 1000 MG TABLET

ISTAMET D XR 1000 MG Tablet, manufactured by SUN PHARMA LABORATORIES LTD., is a prescription medicine formulated for the management of Type 2 Diabetes Mellitus in adults. This extended-release tablet combines three active ingredients to help control blood sugar levels effectively.

Composition Each ISTAMET D XR 1000 MG Tablet contains:

• Dapagliflozin: 10 mg
• Metformin Hydrochloride: 1000 mg
• Sitagliptin: 100 mg

Uses ISTAMET D XR 1000 MG Tablet is primarily used to:

• Improve blood sugar control in adults with Type 2 Diabetes Mellitus, often in conjunction with diet and exercise.
• Help regulate blood sugar levels by enhancing insulin sensitivity, increasing glucose excretion through urine, and reducing glucose production in the liver.
• Reduce the risk of hospitalization due to heart failure in patients with established cardiovascular disease or multiple cardiovascular risk factors.
• Support weight loss and improve overall metabolic health in some individuals with Type 2 Diabetes.

Dosage and Administration ISTAMET D XR 1000 MG Tablet should be taken exactly as advised by your doctor. It can be consumed with or without food, but it is recommended to take it at the same time each day for optimal benefits. The tablet should be swallowed whole and not chewed, crushed, or broken. Do not discontinue the medication without consulting your doctor, as stopping abruptly may lead to increased blood sugar levels and serious complications.

Side Effects

• Common Side Effects: Nausea, headache, dizziness, fatigue, stomach upset, diarrhea, vomiting, abdominal pain, increased urination, dry mouth, urinary tract infection (UTI), nasal congestion, sore throat, upper respiratory tract infection, and genital mycotic (fungal) infections.
• Serious Side Effects: Seek immediate medical attention if you experience signs of lactic acidosis (e.g., weakness, difficulty breathing, severe stomach pain), hypoglycemia (low blood sugar), pancreatitis (severe abdominal pain), kidney problems, or allergic reactions such as rash, swelling of the face, tongue, or lips, or breathing difficulties.

Precautions

• Inform your doctor about any existing kidney or liver problems, urinary tract infections, heart failure, or a history of pancreatitis.
• Pregnant or breastfeeding women should consult their doctor before using this medication. It is generally not recommended during breastfeeding.
• Avoid excessive alcohol consumption, as it can increase the risk of serious side effects like lactic acidosis and hypoglycemia.
• Caution is advised when taken with diuretics or with insulin and insulin secretagogues, as this may lead to low blood pressure or extremely low blood sugar levels, respectively.
• This medicine is not suitable for individuals with Type 1 diabetes or diabetic ketoacidosis.
• Regular monitoring of blood sugar levels is crucial during treatment.
• Maintain good personal hygiene to help prevent genital fungal infections.

Storage Store ISTAMET D XR 1000 MG Tablet in a cool and dry place, protected from direct sunlight. Keep the medicine out of the sight and reach of children. Store at a temperature between 10°C to 25°C or below 30°C.

What is ISTAMET D XR 1000 MG TABLET used for?

ISTAMET D XR 1000 MG TABLET is an antidiabetic medicine primarily used to manage Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels when diet and exercise alone are not sufficient. Additionally, it may aid in reducing the risk of hospitalization due to heart failure and diabetic kidney disease in certain patients with cardiovascular risk factors.

How does ISTAMET D XR 1000 MG TABLET work?

This medicine is a combination of three active ingredients: Dapagliflozin, Sitagliptin, and Metformin, which work together to control blood sugar levels.

• Dapagliflozin works by increasing the removal of excess sugar from the body through urine.
• Sitagliptin increases the levels of natural substances (incretins) that help the pancreas release more insulin and decrease sugar production when blood sugar is high.
• Metformin reduces the amount of sugar produced by the liver, delays sugar absorption from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage of ISTAMET D XR 1000 MG TABLET?

The typical recommended dosage is one tablet once daily. However, your doctor will determine the appropriate dose based on your individual needs and how your body responds to the medicine. It should be swallowed whole and not crushed, broken, or chewed. It can be taken with or without food, but it is best to take it at the same time each day to maintain a consistent routine.

What are the possible side effects of ISTAMET D XR 1000 MG TABLET?

Common side effects may include:

• Urinary tract infections (UTIs)
• Nasal congestion or sore throat (nasopharyngitis)
• Upper respiratory tract infections
• Nausea
• Vomiting
• Abdominal pain or stomach upset
• Headache
• Genital fungal infections

Most of these side effects are temporary and usually resolve over time. If they persist or worsen, you should consult your doctor. Serious but rare side effects can include lactic acidosis, hypoglycemia (low blood sugar), and pancreatitis.

Is ISTAMET D XR 1000 MG TABLET safe during pregnancy or breastfeeding?

There is limited information on the effect of ISTAMET D XR 1000 MG TABLET during pregnancy, and it is generally not recommended. It is also generally not recommended for use during breastfeeding, as it is not known if it passes into human breast milk. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medicine.

Can ISTAMET D XR 1000 MG TABLET be taken with other medications?

ISTAMET D XR 1000 MG TABLET can interact with certain medications. It is crucial to inform your doctor about all other medicines, herbal products, or supplements you are currently taking or might take to avoid potential interactions. Particular care should be taken if you are on:

• Diuretics (water pills), as this may increase the risk of dehydration and low blood pressure.
• Insulin or insulin secretagogues (like sulfonylureas), as this combination may lead to extremely low blood sugar levels.
• Corticosteroids, which may increase blood glucose levels.
• Medicines for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), or HIV/AIDS (e.g., ritonavir), especially if you have kidney disorders.
• Medicines for heart failure (e.g., digoxin).
• Carbonic anhydrase inhibitors (e.g., acetazolamide, dorzolamide) or renal function impairing medications (e.g., ranolazine, vandetanib, dolutegravir, cimetidine), as these can increase the risk of metformin-associated lactic acidosis.

What precautions should be taken with ISTAMET D XR 1000 MG TABLET?

• Do not take this medicine if you are allergic to any of its components.
• Inform your doctor about your medical history, especially if you have liver or kidney disease, heart failure, or a history of low blood pressure.
• Avoid excessive alcohol consumption while taking this medicine, as it can increase the risk of lactic acidosis and hypoglycemia.
• Maintain good hygiene to help prevent genital fungal infections.
• Regularly monitor your blood sugar levels as advised by your doctor.
• Stay well-hydrated by drinking plenty of fluids.
• This medicine is not recommended for children below 18 years of age.
• Be cautious when driving or operating machinery if you experience dizziness or sleepiness.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should ISTAMET D XR 1000 MG TABLET be stored?

Store ISTAMET D XR 1000 MG TABLET in a cool and dry place, protected from direct sunlight, typically between 10ºC to 30ºC. Keep it out of the sight and reach of children and pets.