Nexovas O 40 Tab

NEXOVAS O 40 Tablet

NEXOVAS O 40 Tablet is a prescription medication manufactured by Macleods Pharmaceuticals Pvt Ltd, primarily used for the management of high blood pressure (hypertension).

Composition

NEXOVAS O 40 Tablet contains a combination of two active ingredients:

• Olmesartan medoxomil (40 mg)
• Cilnidipine (10 mg)

Olmesartan is an angiotensin II receptor blocker (ARB) that works by blocking the hormone angiotensin, leading to the relaxation of blood vessels. Cilnidipine is a calcium channel blocker that prevents the contraction of blood vessels and reduces the heart's workload. Together, these actions allow blood to flow more smoothly and the heart to pump more efficiently, thereby lowering blood pressure.

Uses

NEXOVAS O 40 Tablet is prescribed for:

• Treatment of hypertension (high blood pressure) in adults.
• Reducing the risk of serious cardiovascular events such as heart attack and stroke, by effectively controlling blood pressure.

Dosage and Administration

The dosage and duration of treatment for NEXOVAS O 40 Tablet are determined by a doctor based on the patient's medical condition and response to therapy.

• It is typically taken once daily.
• The tablet can be taken with or without food, but it is recommended to take it regularly at a fixed time each day for consistent effects.
• Swallow the tablet whole with a glass of water. Do not chew, crush, or break it.
• Do not stop taking this medicine without consulting your doctor, as abrupt discontinuation can lead to a rise in blood pressure.

Side Effects

Common side effects of NEXOVAS O 40 Tablet may include:

• Headache
• Dizziness
• Fatigue/Tiredness
• Nausea
• Peripheral oedema (swelling of legs/hands/ankles)
• Increased serum potassium levels
• Increased serum creatinine levels

Serious side effects, though less common, warrant immediate medical attention:

• Skin rash or itchiness
• Painful joints
• Fast or irregular heartbeat
• Shortness of breath or tightness in the chest
• Aching, tender, or weak muscles not caused by exercise
• Severe, persistent diarrhea causing substantial weight loss
• Symptoms indicating high potassium levels in the blood, such as muscle weakness or changes in heart rhythm.

Precautions

• Pregnancy and Breastfeeding: NEXOVAS O 40 Tablet is unsafe during pregnancy, especially in the second and third trimesters, due to potential risks to the fetus. It is not recommended for use in breastfeeding women as its effect on the baby is unknown.
• Medical Conditions: Inform your doctor if you have kidney disease, liver disease (especially severe liver disease), heart problems (e.g., heart failure, aortic stenosis, cardiogenic shock), low blood pressure (hypotension), chest pain (angina), severe vomiting or diarrhea, or problems with your adrenal glands.
• Drug Interactions:
  • Avoid concomitant use with medicines containing aliskiren, particularly in patients with diabetes or kidney problems.
  • Concomitant use with ACE inhibitors (e.g., captopril, enalapril) is generally not recommended.
  • Lithium levels may increase if taken with NEXOVAS O 40 Tablet, potentially leading to toxicity.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect and increase the risk of kidney problems.
  • Avoid grapefruit juice and St. John's wort.
  • Alcohol consumption should be avoided as it can enhance the blood pressure-lowering effect and cause dizziness.
• Driving and Operating Machinery: This medicine may cause dizziness or drowsiness; therefore, avoid driving or operating heavy machinery until you know how it affects you.
• Children: NEXOVAS O 40 Tablet is not generally recommended for use in children. Some sources indicate it may be used in children above 6 years for high blood pressure, but this should be strictly under medical guidance.

Storage

Store NEXOVAS O 40 Tablet below 25°C or 30°C. Keep it in a cool, dry place, away from heat and direct light. Ensure it is out of the reach of children and pets.

What is Nexovas O 40 Tablet used for?

Nexovas O 40 Tablet is primarily used for the management of hypertension, also known as high blood pressure, in adults. This combination medicine helps to regulate blood flow by relaxing blood vessels, thereby reducing the risk of stroke and heart attack. It can be used alone or in conjunction with other antihypertensive agents to effectively control blood pressure levels.

How does Nexovas O 40 Tablet work?

Nexovas O 40 Tablet contains two active ingredients: Cilnidipine (10 mg) and Olmesartan Medoxomil (40 mg).

• Cilnidipine is a calcium channel blocker. It works by blocking calcium channels in the body, which helps to relax the smooth muscles of the blood vessels, leading to a decrease in blood pressure.
• Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB). It works by blocking the effects of a hormone called angiotensin II, which normally constricts blood vessels. By blocking this action, it relaxes and widens blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. The combined action of these two ingredients effectively lowers high blood pressure and reduces the heart's workload.

What is the usual dosage for Nexovas O 40 Tablet?

Nexovas O 40 Tablet is typically taken orally, usually once daily, with or without food. It is important to take the medicine regularly at a fixed time each day as prescribed by your doctor. The specific dose and duration will be determined by your doctor based on your medical condition and how you respond to the medicine. Do not alter the dose or stop taking the medicine without consulting your doctor.

What are the possible side effects of Nexovas O 40 Tablet?

Common side effects of Nexovas O 40 Tablet may include headache, dizziness, fatigue, nausea, and peripheral oedema (swelling in the limbs, typically legs or feet). Other reported side effects include increased serum potassium and creatinine levels, sleepiness, taste changes, flushing, and upset stomach. Most side effects are temporary and resolve over time, but if they persist or worsen, you should consult your doctor. Serious side effects can include skin rash, itchiness, painful joints, fast heartbeat, shortness of breath, chest tightness, aching/tender/weak muscles, and severe swelling of hands, feet, or ankles.

Is Nexovas O 40 Tablet safe during pregnancy or breastfeeding?

Nexovas O 40 Tablet is generally not recommended during pregnancy. It should not be used during the second and third trimesters due to potential risks to the fetus. If you are pregnant, planning to conceive, or become pregnant while taking this medicine, you must consult your doctor immediately.

Regarding breastfeeding, it is not known whether the ingredients of Nexovas O 40 Tablet pass into breast milk. Therefore, it is generally not recommended for use in breastfeeding women, and a decision should be made in consultation with your doctor to either stop nursing or discontinue the medicine.

Can Nexovas O 40 Tablet be taken with other medications?

Nexovas O 40 Tablet can interact with other medications. It's crucial to inform your doctor about all prescription, over-the-counter, herbal medications, and supplements you are taking.

• Potassium supplements and potassium-sparing diuretics may increase the risk of hyperkalemia (too much potassium in your blood).
• Lithium-based medicines can have their levels increased in the blood, leading to lithium toxicity.
• NSAIDs (like ibuprofen or naproxen) can reduce the blood pressure-lowering effect and increase the risk of kidney problems.
• CYP3A4 inhibitors (such as itraconazole or ritonavir) can increase the levels of cilnidipine in your body, potentially leading to more side effects.
• Other antihypertensive medications may increase the blood pressure-lowering effect.
• Aliskiren should not be used with Nexovas O 40 Tablet if you have diabetes or renal impairment. Grapefruit juice may also increase the blood levels of Cilnidipine, increasing the risk of side effects, and should be avoided.

What precautions should be taken while taking Nexovas O 40 Tablet?

• Alcohol Consumption: Alcohol may enhance the blood pressure-lowering effect of Nexovas O 40 Tablet and can cause dizziness, headache, and changes in heart rate. It is advised to avoid or limit alcohol intake.
• Driving and Operating Machinery: This medicine may cause dizziness, sleepiness, or affect vision. Avoid driving or performing activities that require concentration until you know how the medicine affects you.
• Kidney and Liver Conditions: Use with caution if you have kidney or liver problems, as it may worsen your condition. Regular monitoring of kidney function may be necessary.
• Low Blood Pressure: Inform your doctor if you have low blood pressure (hypotension) or conditions like cardiogenic shock or aortic stenosis.
• Dehydration: Inform your doctor if you have severe dehydration.
• Sudden Discontinuation: Do not stop taking Nexovas O 40 Tablet suddenly without consulting your doctor, as it may lead to a sudden increase in blood pressure and increased risk of heart attack or stroke.
• Diet: Maintaining a low-salt and low-fat diet can help the medication work better.

What happens if a dose is missed?

If you miss a dose of Nexovas O 40 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Always consult your doctor before altering the prescribed dosage.

How should it be stored?

Nexovas O 40 Tablet should be stored at room temperature, below 30°C, away from heat and direct light. Keep it out of the reach of children and pets. Do not use the medicine past its expiry date.