Valkem Od 1000

VALKEM OD 1000

Name: VALKEM OD 1000 (brand name); Divalproex Sodium (common name) Manufactured by Alkem Laboratories Ltd.

Composition: Each extended-release tablet contains Divalproex Sodium 1000 mg.

Uses: VALKEM OD 1000 is primarily prescribed for:

• Epilepsy/Seizures: It is an anticonvulsant that stabilizes electrical activity in the brain, thereby preventing and controlling seizures (fits).
• Bipolar Disorder: Used in the management of manic episodes associated with bipolar disorder, helping to stabilize mood and reduce extreme emotional shifts.
• Migraine Prevention: Utilized as a preventive measure to reduce the frequency and intensity of migraine headaches.

Dosage and Administration: VALKEM OD 1000 is for oral administration. The tablet should be swallowed whole with water, without crushing, chewing, or breaking it. It can be taken with or without food, but it is advisable to take it at the same time each day to maintain consistent blood levels and maximize effectiveness. The dosage and duration of treatment are determined by a healthcare professional based on the patient's condition and response. Do not stop taking this medication suddenly, as abrupt cessation can trigger seizures or worsen the condition.

Side Effects: Common side effects may include:

• Headache
• Blurred vision, double vision
• Nausea, vomiting, abdominal pain, diarrhea, constipation
• Dizziness, fatigue, sleepiness, unsteadiness, tremors
• Weight gain, increased appetite
• Bruising
• Decreased body temperature
• Hair loss

More serious, though less common, side effects include:

• Skin rash or redness
• Liver injury (especially in children under 2 years)
• Anemia (low red blood cell count)
• Decreased sodium level in blood
• Hypersensitivity
• Deafness, urinary incontinence
• Pancreatitis
• Osteoporosis (reduced bone mass) with long-term use
• Mood and behavioral changes, including suicidal thoughts

Consult a doctor if any side effects persist or worsen, or if serious symptoms occur.

Precautions:

• Contraindications: Do not use if allergic to Divalproex, or if you have liver problems, urea cycle disorders, or porphyria.
• Pregnancy and Breastfeeding: Not recommended during pregnancy due to the risk of serious birth defects (Category D). Effective contraception is advised for women of childbearing age. Consult a doctor if pregnant, planning pregnancy, or breastfeeding.
• Liver/Kidney Problems: Use with caution in patients with kidney impairment and is not recommended for those with liver injury or a family history of liver injury. Liver function tests are often performed before and during treatment.
• Other Medical Conditions: Inform your doctor about any history of heart issues, depression, suicidal thoughts, pancreatitis, blood problems, or multi-organ hypersensitivity.
• Alcohol: Avoid or limit alcohol consumption, as it can intensify side effects like dizziness and sleepiness, and increase the risk of seizures.
• Drug Interactions: Inform your doctor about all current medications, as Divalproex Sodium can interact with drugs like Warfarin, Lamotrigine (potentially causing serious skin reactions), and other antiepileptic drugs, requiring dose adjustments.
• Activities: May cause dizziness and sleepiness; avoid driving or operating heavy machinery until you know how the medicine affects you.
• Monitoring: Regular blood tests may be ordered to monitor the effects on the body, and weight should be monitored due to potential weight gain.

Storage: Store VALKEM OD 1000 at controlled room temperature (15-30°C or below 30°C), away from moisture and heat. Keep out of the sight and reach of children and pets.

Frequently Asked Questions About VALKEM OD 1000

What is VALKEM OD 1000 used for?

VALKEM OD 1000 is an anticonvulsant medication primarily used for the treatment of epilepsy and seizures. It is also prescribed for managing manic or mixed episodes associated with bipolar disorder and for the prevention of migraine headaches.

How does VALKEM OD 1000 work?

VALKEM OD 1000 contains Divalproex sodium, which works by calming overactive nerve signals in the brain. It does this by reducing abnormal electrical activity and increasing the levels of a natural brain chemical called gamma-aminobutyric acid (GABA), which helps to block nerve transmission and produce a calming effect.

What is the usual dosage for VALKEM OD 1000?

The exact dosage and frequency of VALKEM OD 1000 will be determined by your doctor based on your specific condition and response to the medication. It is generally recommended to take the tablet whole, without crushing or chewing, at the same time each day, with or without food, for optimal results. It may take a few weeks for the medication to show its full effect.

What are the possible side effects of VALKEM OD 1000?

Common side effects can include headache, blurred vision, nausea, vomiting, dizziness, fatigue, unsteadiness, bruising, decreased body temperature, abdominal pain, diarrhea, and weight gain. More serious, but rare, side effects may include skin rash, changes in mood (including suicidal thoughts), or liver injury. You should consult your doctor if any side effects persist, become bothersome, or if you notice any severe reactions.

Is VALKEM OD 1000 safe during pregnancy or breastfeeding?

VALKEM OD 1000 is generally considered unsafe during pregnancy as there is definite evidence of risk to the developing baby and it can lead to serious birth defects. Women of childbearing age are advised to use effective contraception during treatment. During breastfeeding, it should be used with caution, and you should consult your doctor as it may pass into breastmilk, although typically not in harmful amounts.

Can VALKEM OD 1000 be taken with other medications?

It is crucial to inform your doctor about all other medications you are currently taking, including over-the-counter drugs and herbal supplements, as some can interact negatively with VALKEM OD 1000. For example, it can increase the concentration of lamotrigine, potentially causing serious skin reactions, and may reduce the effectiveness of oral contraceptives.

What precautions should be taken while taking VALKEM OD 1000?

Before taking VALKEM OD 1000, inform your doctor if you have a history of heart issues, liver or kidney problems, difficulty urinating, depression, or suicidal thoughts. Avoid consuming alcohol, as it can intensify certain side effects and increase the risk of seizures. This medication may cause dizziness or sleepiness, so caution is advised when driving or operating machinery. Do not stop taking the medication abruptly, as this can worsen your condition or trigger seizures; gradual discontinuation should always be under medical supervision.

What happens if a dose of VALKEM OD 1000 is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. Missing doses can disrupt treatment and potentially lead to seizures or a worsening of your condition.

How should VALKEM OD 1000 be stored?

VALKEM OD 1000 should be stored at room temperature, ideally below 30°C, and away from moisture and heat. Keep it out of the sight and reach of children and pets.

Can VALKEM OD 1000 cause weight gain?

Yes, weight gain is a potential side effect of VALKEM OD 1000, possibly due to an increase in appetite. Monitoring your weight, maintaining a healthy diet, and exercising regularly can help manage this side effect. If you have concerns about weight gain, consult your doctor.