Lyvelsa 10 Mg Tab

LYVELSA 10 MG Tablet

LYVELSA 10 MG Tablet is a medication used in the management of chronic kidney disease (CKD) associated with type 2 diabetes (T2D).

• Name

  • Brand Name: LYVELSA 10 MG
  • Common Name: Finerenone

• Composition

  • Each tablet contains 10 mg of Finerenone as the active ingredient.

• Uses LYVELSA is prescribed to reduce the risk of:

  • Sustained decline in estimated glomerular filtration rate (eGFR).
  • End-stage kidney disease.
  • Cardiovascular death.
  • Nonfatal myocardial infarction.
  • Hospitalization for heart failure in adult patients with CKD associated with T2D. It works by selectively blocking the mineralocorticoid receptor, which helps to reduce inflammation and fibrosis in the kidneys and heart.

• Dosage and Administration

  • The recommended starting dosage is typically 10 mg or 20 mg orally once daily, based on eGFR and serum potassium thresholds.
  • The dosage may be increased after 4 weeks to a target dose of 20 mg once daily, depending on eGFR and serum potassium levels.
  • Tablets can be taken with or without food.
  • For patients unable to swallow whole tablets, Finerenone may be crushed and mixed with water or soft foods.
  • Regular monitoring of kidney function and electrolytes is necessary during treatment.

• Side Effects Common side effects may include:

  • Hyperkalemia (high potassium levels in the blood)
  • Hypotension (low blood pressure)
  • Hyponatremia (low sodium levels in the blood)
  • Dizziness
  • Fatigue
  • Headache

• Precautions

  • Hyperkalemia: LYVELSA can cause hyperkalemia. Serum potassium and eGFR should be measured before initiating treatment and periodically thereafter. Do not initiate if serum potassium is > 5.0 mEq/L.
  • Drug Interactions: Concomitant use with strong CYP3A4 inhibitors is contraindicated. Avoid concomitant intake of grapefruit or grapefruit juice.
  • Pregnancy and Lactation: Avoid use during pregnancy and breastfeeding due to potential risks to the infant. Effective contraception is advised for women of childbearing potential.
  • Hepatic Impairment: Avoid use in severe hepatic impairment.

• Storage

  • Store below 30°C.
  • Keep away from light and moisture.
  • Keep out of the reach of children.

What is LYVELSA 10 MG Tablet used for?

LYVELSA 10 MG Tablet is used to treat chronic kidney disease (CKD) in adults who also have type 2 diabetes. It helps to slow down kidney damage, reduce the risk of kidney failure, and lower the chances of heart complications such as heart attack and heart failure. It also helps reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, non-fatal myocardial infarction, and hospitalization for heart failure.

How does LYVELSA 10 MG Tablet work?

LYVELSA 10 MG Tablet contains Finerenone, which is a non-steroidal mineralocorticoid receptor (MR) antagonist. It works by selectively blocking the mineralocorticoid receptor, thereby reducing inflammation and fibrosis in the kidneys and heart. This action helps to counteract the effects of hormones like aldosterone, which can cause salt and water retention leading to kidney and heart damage.

What is the usual dosage for LYVELSA 10 MG Tablet?

The initial dosage of LYVELSA 10 MG Tablet is typically 10 mg or 20 mg orally once daily, which is determined by your doctor based on your estimated glomerular filtration rate (eGFR) and serum potassium levels. The dosage may be increased to a target of 20 mg once daily after four weeks, also based on eGFR and serum potassium thresholds. It should not be initiated if your serum potassium is greater than 5.0 mEq/L. This medicine is not recommended for patients with an eGFR less than 25 mL/min. The tablet should be swallowed whole with a glass of water, and can be taken with or without food. Do not crush, chew, or split the tablet.

What are the possible side effects of LYVELSA 10 MG Tablet?

Common side effects of LYVELSA 10 MG Tablet include hyperkalemia (high potassium levels), hypotension (low blood pressure), hyponatremia (low sodium levels), and hyperuricemia (high uric acid levels). Other symptoms can include weakness, tiredness, nausea, dizziness, headache, confusion, muscle weakness, spasms or cramps, and numbness in the hands and lips. Most of these side effects are usually temporary and resolve over time. If you experience any severe or persistent side effects, you should consult your doctor.

Is LYVELSA 10 MG Tablet safe during pregnancy or breastfeeding?

Pregnancy: LYVELSA 10 MG Tablet is generally not recommended during pregnancy unless your doctor determines it is absolutely necessary. Women of childbearing potential should use effective contraception to prevent pregnancy while taking this medication.

Breastfeeding: It is not recommended to breastfeed while taking LYVELSA 10 MG Tablet, as it might pass into breast milk and potentially harm the nursing infant.

Can LYVELSA 10 MG Tablet be taken with other medications?

LYVELSA 10 MG Tablet can interact with other medications. It is contraindicated with strong CYP3A4 inhibitors (such as ketoconazole, clarithromycin, itraconazole, and certain anti-HIV agents like ritonavir). Concomitant use with potassium-sparing diuretics or potassium supplements should be avoided due to an increased risk of high potassium levels. You should also avoid grapefruit or grapefruit juice while taking this medication. Always inform your doctor about all prescription, over-the-counter medications, supplements, and herbal products you are taking to prevent potential interactions. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are generally not recommended due to an increased risk of bleeding.

What precautions should be taken while using LYVELSA 10 MG Tablet?

Before starting LYVELSA 10 MG Tablet, your doctor will measure your serum potassium and eGFR levels, and monitor them periodically during treatment. Do not start this medication if your serum potassium is above 5.0 mEq/L. Caution is advised for elderly patients due to a higher risk of hyperkalemia. It is not recommended for individuals with severe liver impairment and should be used with caution in those with mild to moderate liver issues. Inform your doctor if you have a history of hyperkalemia, severe renal illness, heart failure, or Addison's disease. Limit or avoid alcohol consumption, and be cautious when driving or operating machinery if you experience dizziness or drowsiness.

What happens if a dose of LYVELSA 10 MG Tablet is missed?

If you miss a dose of LYVELSA 10 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should LYVELSA 10 MG Tablet be stored?

LYVELSA 10 MG Tablet should be stored in a cool, dry place, protected from direct sunlight, moisture, and heat. Keep the medication out of the reach of children. It is typically stored at room temperature, generally below 30°C. Do not use the medicine after the expiry date printed on the package.