Istamet 50mg/500mg Tablet
Sitagliptin undefined (50mg) + undefined Metformin (500mg)
Source ID: 200393
₹176.25
₹132.54
(Inclusive of all taxes)Batch
SIH0027A
PKG
15 TABLETS
Expiry
2027-12-31
MRP
₹176.25
Stock
10
Discount
24.8%
Description
ISTAMET 50MG/500MG TABLET
Name:
- Brand Name: ISTAMET 50MG/500MG TABLET
- Common Names: Sitagliptin and Metformin tablets
Composition: Each tablet contains:
- Sitagliptin: 50 mg
- Metformin: 500 mg
Uses: ISTAMET 50MG/500MG TABLET is prescribed for the management of type 2 diabetes mellitus in adults. It is used in conjunction with a healthy diet and regular exercise to control high blood sugar levels. This medication helps to improve glycemic control by enhancing insulin sensitivity, reducing glucose production in the liver, and increasing the body's natural insulin release after meals. Effective blood sugar control helps prevent serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.
Dosage and Administration: ISTAMET 50MG/500MG TABLET is typically taken orally, usually twice daily with meals to minimize stomach upset. The tablet should be swallowed whole with water and not crushed, chewed, or broken. It is advised to take the medicine at the same time each day for best results. Your doctor will determine the appropriate dosage based on your blood sugar levels and medical history. Do not adjust the dose or stop the medication without consulting your doctor.
Side Effects: Common Side Effects:
- Hypoglycemia (low blood sugar), especially when taken with other anti-diabetic medicines
- Dizziness, headache, weakness, drowsiness
- Nausea, vomiting, diarrhea, stomach pain/upset, flatulence, changes in taste
- Upper respiratory tract infection, sore throat
Serious Side Effects (Rare):
- Lactic acidosis (symptoms include muscle pain, difficulty breathing, tiredness, stomach pain, coldness in limbs, slow heart rate)
- Pancreatitis (inflammation of the pancreas)
- Vitamin B12 deficiency with long-term use
- Skin blisters
Precautions:
- Contraindications: Avoid if allergic to any components, or if you have type 1 diabetes, severe kidney or liver disease, diabetic ketoacidosis, or severe dehydration.
- Alcohol: Limit or avoid alcohol consumption as it increases the risk of lactic acidosis and hypoglycemia.
- Pregnancy and Breastfeeding: Not recommended during pregnancy unless clearly necessary, as it may harm the fetus. Consult your doctor if pregnant, planning a pregnancy, or breastfeeding.
- Other Conditions: Use with caution in patients with heart conditions, a history of pancreatitis, gallstones, or low vitamin B12 levels. Regular monitoring of kidney function, blood sugar levels, and potentially TSH is advised.
- Driving: May cause dizziness or drowsiness, so exercise caution when driving or operating machinery.
Storage: Store in a cool and dry place, away from direct sunlight. Keep out of sight and reach of children. Store at room temperature, typically between 10-30°C (or 20°C to 25°C). Do not freeze.
₹176.25
₹132.54
(Inclusive of all taxes)Frequently Asked Questions
What is ISTAMET 50MG/500MG TABLET used for?
ISTAMET 50MG/500MG TABLET is a combination medicine primarily used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels when taken alongside a proper diet and regular exercise. Controlling blood sugar helps prevent serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.
How does ISTAMET 50MG/500MG TABLET work?
This medicine contains two active ingredients: Sitagliptin (50mg) and Metformin (500mg). Sitagliptin is a DPP-4 inhibitor that works by increasing the levels of certain natural hormones (incretins) in the body. These hormones stimulate the pancreas to produce more insulin when blood sugar levels are high and reduce the production of glucagon, a hormone that raises blood sugar. Metformin is a biguanide that works by reducing glucose production in the liver, delaying the absorption of glucose from the intestines, and improving the body's sensitivity to insulin. Together, they provide better control of blood sugar levels.
What is the usual dosage for ISTAMET 50MG/500MG TABLET?
The dosage of ISTAMET 50MG/500MG TABLET is individualized by your doctor based on your condition, blood sugar levels, and other medications you may be taking. It is typically taken once or twice daily with meals to help reduce stomach upset. The maximum daily dose should generally not exceed 100 mg of sitagliptin and 2000 mg of metformin. Always follow your doctor's prescribed schedule and do not adjust the dose without consultation.
What are the possible side effects of ISTAMET 50MG/500MG TABLET?
Common side effects can include diarrhea, headache, upper respiratory tract infection, nausea, stomach discomfort, gas (flatulence), constipation, changes in taste, and dry mouth. Low blood sugar (hypoglycemia) is a possible side effect, especially if you are taking other diabetes medicines like insulin or sulfonylurea. Serious but rare side effects include lactic acidosis (a medical emergency, especially if you have kidney or liver issues) and vitamin B12 deficiency with long-term use. Inform your doctor if any side effects persist or worsen.
Is ISTAMET 50MG/500MG TABLET safe during pregnancy or breastfeeding?
It is generally advised to consult your doctor before taking ISTAMET 50MG/500MG TABLET if you are pregnant or breastfeeding. The use of this medicine is often considered unsafe or contraindicated during pregnancy and breastfeeding, as metformin can pass into breast milk.
Can ISTAMET 50MG/500MG TABLET be taken with other medications?
ISTAMET 50MG/500MG TABLET may interact with other medications, potentially affecting blood sugar levels or increasing side effects. Inform your doctor about all other medicines, supplements, or herbals you are taking. Caution is advised with cationic medications (e.g., amiloride, trimethoprim), diuretics, corticosteroids (which can increase blood sugar), and thyroid medications. If taken with other diabetes medicines like insulin or sulfonylureas, the risk of hypoglycemia may increase.
What precautions should be taken while using ISTAMET 50MG/500MG TABLET?
Avoid consuming alcohol while taking this medicine, as it can increase the risk of lactic acidosis and severe hypoglycemia. Inform your doctor if you have kidney, liver, or heart disease, a history of pancreatitis, type 1 diabetes, diabetic ketoacidosis, or if you are severely dehydrated. Regular monitoring of kidney function, blood sugar levels, and potentially vitamin B12 levels is recommended during treatment. Take the tablet with meals to minimize stomach upset.
What happens if a dose of ISTAMET 50MG/500MG TABLET is missed?
If you forget a dose of ISTAMET 50MG/500MG TABLET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose, as this can lead to fluctuations in blood sugar levels.
How should ISTAMET 50MG/500MG TABLET be stored?
ISTAMET 50MG/500MG TABLET should be stored at room temperature, typically between 10°C to 30°C, or below 30°C. Keep it away from moisture, heat, and direct light. Ensure it is kept out of the sight and reach of children and pets. Do not freeze the medicine.