Rozucor Asp 20/150 (10 Cap)

ROZUCOR ASP 20/150 (10 CAP) by TORRENT PHARMACEUTICALS LTD.

ROZUCOR ASP 20/150 is a combination medication designed to manage high lipid levels and reduce the risk of serious cardiovascular events.

Composition

ROZUCOR ASP 20/150 contains two active ingredients:

• Rosuvastatin (20 mg)
• Aspirin (150 mg)

Rosuvastatin is a statin that lowers "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL) by inhibiting a liver enzyme essential for cholesterol production. Aspirin is a non-steroidal anti-inflammatory drug (NSAID) with anti-platelet action, which prevents platelets from clumping together and forming blood clots.

Uses

This medicine is primarily used for:

• Prevention of heart attack and stroke in high-risk individuals
• Management of high cholesterol levels (dyslipidemia)
• Reducing the risk of atherosclerosis (fatty deposits in blood vessels) and peripheral vascular disease
• Management of angina (heart-related chest pain)

Dosage and Administration

ROZUCOR ASP 20/150 capsules should be swallowed whole, not crushed or chewed. It is typically taken once daily with food to minimize stomach upset. The exact dosage and duration are determined by a doctor based on the patient's condition. It's crucial to follow the prescribed schedule and not stop the medication abruptly.

Side Effects

Common side effects may include:

• Indigestion, stomach pain, constipation, nausea, vomiting
• Headache, dizziness
• Muscle pain or weakness
• Increased bleeding tendency

Serious side effects that require medical attention include severe muscle pain with fever or dark urine, and yellowing of the skin or eyes.

Precautions

• Pregnancy and Breastfeeding: ROZUCOR ASP 20/150 is contraindicated during pregnancy and generally considered unsafe during breastfeeding.
• Liver/Kidney Disease: Use with caution in patients with liver or kidney impairment; dose adjustments may be necessary.
• Bleeding Disorders: Caution is advised for individuals with a history of bleeding disorders or those at risk of bleeding due to the aspirin component.
• Alcohol: Consumption of alcohol should be limited as it may increase the risk of liver problems.
• Drug Interactions: Inform your doctor about all medications you are taking, especially blood thinners (e.g., warfarin, heparin), other NSAIDs (e.g., ibuprofen), cyclosporine, methotrexate, and fusidic acid, as interactions can occur.
• Surgery: Patients should inform their doctor about taking this medication before any surgery or dental procedure due to an increased risk of bleeding.

Storage

Store the medicine in a cool and dry place, away from direct sunlight, and out of sight and reach of children. It should generally be stored below 30°C.

ROZUCOR ASP 20/150 is a combination medicine containing Rosuvastatin (20mg) and Aspirin (150mg). It is manufactured by Torrent Pharmaceuticals Ltd..

What is ROZUCOR ASP 20/150 used for?

ROZUCOR ASP 20/150 is primarily used to manage high cholesterol levels (dyslipidemia) and to prevent cardiovascular events such as heart attack, stroke, and peripheral vascular disease (blockage in blood vessels outside the heart). It also helps reduce the risk of atherosclerosis (fatty deposits in blood vessels) and can be used in the management of angina (chest pain).

How does ROZUCOR ASP 20/150 work?

This medicine combines two active ingredients:

• Rosuvastatin: This is a statin that works by blocking an enzyme (HMG-CoA reductase) in the liver responsible for making cholesterol. This action reduces levels of "bad" cholesterol (LDL) and triglycerides, while increasing "good" cholesterol (HDL) in the blood.
• Aspirin: This is a non-steroidal anti-inflammatory drug (NSAID) with antiplatelet effects. It prevents platelets (blood cells) from clumping together to form blood clots, thereby improving blood flow and reducing the risk of clot formation in blood vessels.

Together, these components help prevent the buildup of plaque in arteries and reduce the risk of serious cardiovascular events.

What is the usual dosage?

The typical dosage of ROZUCOR ASP 20/150 is one capsule daily, taken orally. It's recommended to take it around the same time each day for consistency. The capsule should be swallowed whole without crushing or chewing. Your doctor will determine the appropriate dose and duration of treatment based on your specific medical condition.

What are the possible side effects?

Common side effects may include indigestion, constipation, stomach pain, headache, nausea, muscle pain or weakness, and increased bleeding tendency. Some individuals might also experience dizziness, fatigue, increased blood sugar levels, or protein loss in urine. If side effects worsen or you experience severe muscle pain (especially with fever or dark urine), unusual weakness, dark urine, or yellowing of the skin/eyes, you should contact your doctor immediately.

Is it safe during pregnancy or breastfeeding?

ROZUCOR ASP 20/150 is considered unsafe and contraindicated during pregnancy, as it may harm the unborn baby. Effective birth control measures should be used during treatment. For breastfeeding mothers, it is generally advised to consult a doctor, as components of the medicine may pass into breast milk. While rosuvastatin levels in breast milk are low and unlikely to cause side effects in the baby, the consensus often recommends against breastfeeding while on statins due to concerns about infant lipid metabolism. Aspirin also passes into breast milk in small amounts, and there's a possible link to Reye's syndrome in children with viral infections.

Can it be taken with other medications?

ROZUCOR ASP 20/150 can interact with several other medications. It is crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking.

• Blood thinners (e.g., warfarin, heparin): Concomitant use can increase the risk of bleeding.
• NSAIDs (e.g., ibuprofen, naproxen): Can enhance the blood-thinning effects of aspirin.
• Certain antibiotics (e.g., erythromycin, clarithromycin) and antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir): May alter rosuvastatin levels or increase the risk of muscle problems.
• Antacids containing aluminum and magnesium hydroxide: Can make rosuvastatin less effective if taken too close together (take antacids 2 hours after ROZUCOR ASP).
• Other cholesterol-lowering medicines (e.g., gemfibrozil, fenofibrate): May increase the risk of muscle injury.
• Methotrexate: Should generally not be used with ROZUCOR ASP 20/150. Paracetamol is generally considered safe for pain relief while taking ROZUCOR ASP 20/150.

What precautions should be taken?

• Bleeding risk: This medicine increases the risk of bleeding. Be cautious with activities that may cause injury and inform your doctor if you notice unusual bruising or bleeding. You may need to stop this medicine before any surgery or dental procedure.
• Liver and kidney problems: Use with caution if you have a history of liver or kidney disease. Your doctor may need to monitor your condition.
• Muscle problems: Inform your doctor if you have a history of muscle disorders or experience unusual muscle pain or weakness, especially if accompanied by fever or malaise.
• Diabetes: ROZUCOR ASP 20/150 may increase blood sugar levels, so monitoring is necessary, especially for diabetic patients.
• Alcohol: Excessive alcohol consumption should be avoided as it can increase the risk of liver problems and raise blood pressure.
• Allergies: Do not take if you are allergic to aspirin, rosuvastatin, or any other ingredients in the capsule.
• Do not stop abruptly: Do not discontinue the medicine without consulting your doctor, as it can worsen your condition and increase the risk of future heart attack or stroke.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember on the same day. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.

How should it be stored?

Store ROZUCOR ASP 20/150 in a cool, dry place, typically at room temperature (below 25°C or between 20-25°C), away from direct sunlight, heat, and moisture. Keep the medicine in its original container and out of reach of children and pets. Do not keep outdated medicine and dispose of it safely.