Sitadapa M 100/10/500 Mg (10 Tab)

SITADAPA M 100/10/500 MG (10 TAB) by MACLEODS PHARMACEUTICALS LTD.

• Name: SITADAPA M 100/10/500 Tablet

• Composition: Each tablet contains a combination of three active ingredients:

  • Dapagliflozin 10 mg
  • Sitagliptin 100 mg
  • Metformin Hydrochloride 500 mg

• Uses: SITADAPA M 100/10/500 Tablet is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used when diet, exercise, and therapy with conventional medicines do not result in adequate blood sugar control, or when patients are not adequately controlled by metformin alone or dual therapy. This medication works to improve blood sugar levels and may also help reduce the risk of cardiovascular complications and aid in weight management.

• Dosage and Administration: Take SITADAPA M 100/10/500 Tablet as advised by your physician. It can be taken with or without meals, though taking it with meals may help reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush, break, or chew it. For optimal benefits, it is recommended to take the medicine at the same time each day. Do not discontinue the medication without consulting your doctor.

• Side Effects:

  • Common: Hypoglycemia (low blood glucose level), nausea, vomiting, headache, flatulence, genital infections, increased or frequent urination, diarrhea, stomach pain, drowsiness, dizziness, itching, dry mouth, decreased weight, and thirst.
  • Serious: Seek immediate medical attention if you experience symptoms of acute pancreatitis (severe abdominal pain), severe allergic reactions (rash, swelling), bullous pemphigoid, lactic acidosis, or ketoacidosis.

• Precautions:

  • Not recommended for use during pregnancy or in breastfeeding women.
  • Contraindicated in patients with severe kidney disease, liver disease, respiratory failure, heart failure, recent myocardial infarction, Type 1 diabetes mellitus, or metabolic acidosis.
  • Use with caution in patients with mild to moderate kidney disease.
  • Inform your doctor about all other medications, including herbal supplements, as interactions can occur with diuretics, insulin, sulfonylureas, antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir), and corticosteroids.
  • Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis.
  • Regular monitoring of blood sugar levels and kidney function is crucial.

• Storage: Store SITADAPA M 100/10/500 Tablet at room temperature, below 30°C, in a cool and dry place, away from direct sunlight. Keep out of reach of children and pets.

SITADAPA M 100/10/500 MG is a combination medication containing Dapagliflozin (10 mg), Sitagliptin (100 mg), and Metformin (500 mg). It is primarily used to manage Type 2 Diabetes Mellitus in adults.

What is SITADAPA M 100/10/500 MG used for?

SITADAPA M 100/10/500 MG is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used as an adjunct to diet and exercise to improve blood sugar control. This medication also offers benefits like weight loss support and cardiovascular and renal protective effects in some individuals.

How does SITADAPA M 100/10/500 MG work?

SITADAPA M 100/10/500 MG combines three active ingredients that work through complementary mechanisms to lower blood sugar:

• Dapagliflozin: This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It reduces glucose reabsorption in the kidneys, leading to increased glucose excretion in the urine and thus lowering blood sugar levels.
• Sitagliptin: As a dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin increases the levels of incretin hormones. These hormones enhance insulin release, especially after meals, and decrease glucagon levels, which helps reduce sugar production by the liver when blood sugar is high.
• Metformin: This biguanide works by decreasing the amount of glucose produced by the liver and reducing the absorption of glucose from the intestines. It also improves the body's sensitivity to insulin, allowing cells to utilize glucose more effectively.

What is the usual dosage of SITADAPA M 100/10/500 MG?

The typical starting dose is usually one tablet once daily, taken with food to help reduce gastrointestinal side effects. Your doctor will determine the appropriate dosage based on your individual condition, response to treatment, and other medications you may be taking. It's important to swallow the tablet whole and not to crush, chew, or split it.

What are the possible side effects of SITADAPA M 100/10/500 MG?

Common side effects may include:

• Headache
• Nausea
• Vomiting
• Abdominal pain/stomach upset
• Diarrhea
• Genital fungal infections
• Urinary tract infections (UTIs)
• Common cold symptoms (nasopharyngitis)

More serious, but rare, side effects can include lactic acidosis (due to metformin accumulation, especially with kidney or liver issues) and pancreatitis. If you experience severe or persistent side effects, or symptoms like severe stomach pain, unusual tiredness, or changes in urination, consult your doctor immediately.

Is SITADAPA M 100/10/500 MG safe during pregnancy or breastfeeding?

SITADAPA M 100/10/500 MG is generally not recommended during pregnancy, especially during the second and third trimesters, as there is limited information on its effects on a developing baby. Poorly controlled diabetes during pregnancy can lead to maternal and fetal risks. Insulin is often the preferred treatment for diabetes during pregnancy.

For breastfeeding, this medication is usually not recommended as it's unknown how much of it passes into breast milk and it could potentially affect the baby's sugar levels and kidney development. It's crucial to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as they may suggest alternative medicines.

Can SITADAPA M 100/10/500 MG be taken with other medications?

This combination medication can interact with other drugs. It's important to inform your doctor about all prescription, over-the-counter, and herbal supplements you are taking.

• Insulin and insulin secretagogues (e.g., sulfonylureas): Taking SITADAPA M with these medications may increase the risk of hypoglycemia (low blood sugar), and a dose adjustment of insulin or insulin secretagogue may be necessary.
• Diuretics (water pills): Co-administration with diuretics (like furosemide and hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• Other medications: Caution should be exercised with medicines for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), HIV/AIDS (e.g., ritonavir), and heart failure (e.g., digoxin).

What precautions should be taken while taking SITADAPA M 100/10/500 MG?

• Kidney and Liver Function: This medicine is not recommended for use in patients with severe liver or kidney disease. Your doctor will monitor your kidney function before and during treatment.
• Alcohol: Avoid drinking alcohol while on this medication, as it increases the risk of hypoglycemia and lactic acidosis.
• Dehydration: Ensure adequate fluid intake, as dehydration can increase the risk of lactic acidosis, especially with high fever, excessive sweating, diarrhea, or vomiting.
• Hypoglycemia: While the risk is generally low when taken alone, hypoglycemia can occur, particularly when combined with insulin or sulfonylureas. Carry a source of sugar for immediate relief if you experience symptoms like sweating, dizziness, or palpitations.
• Pancreatitis: Be aware of symptoms of pancreatitis (e.g., sudden and severe stomach pain) and seek medical attention if suspected.
• Surgery/Diagnostic Tests: You may need to stop using this medicine before major surgery or diagnostic tests involving iodinated contrast materials.
• Lifestyle: Adhere to a proper diet and exercise regimen as advised by your doctor to help control blood sugar levels.

What happens if a dose of SITADAPA M 100/10/500 MG is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one, as this can cause your blood sugar level to fall rapidly.

How should SITADAPA M 100/10/500 MG be stored?

Store SITADAPA M in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. Some brands may have specific storage instructions regarding their original container and usage after opening, so check the product packaging or ask your pharmacist.