Trajenta Duo 2.5 Mg/500 Mg Tablet (10 Tab)

TRAJENTA DUO 2.5 MG/500 MG TABLET

TRAJENTA DUO 2.5 MG/500 MG TABLET is a prescription medicine manufactured by BOEHRINGER INGELHEIM INDIA PVT. LTD.

• Name
  • Brand Name: TRAJENTA DUO 2.5 MG/500 MG TABLET
  • Common Name: Linagliptin/Metformin Hydrochloride
• Composition
  • Each film-coated tablet contains 2.5 mg of Linagliptin and 500 mg of Metformin Hydrochloride.
  • Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin is a biguanide.
• Uses
  • TRAJENTA DUO is used in the treatment of Type 2 Diabetes Mellitus as an adjunct to diet and exercise.
  • It helps to control high blood sugar levels by improving the body's response to insulin, reducing sugar production by the liver, delaying glucose absorption from the intestines, and increasing insulin release when needed.
  • Effective management of blood sugar can help prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and heart disease or stroke.
• Dosage and Administration
  • The typical recommended dosage is one tablet twice daily with meals.
  • Swallow the tablet whole with water; do not crush, chew, or break it.
  • Dosage should be individualized by a healthcare professional based on the patient's condition and other medications.
• Side Effects
  • Common: Hypoglycemia (low blood sugar), especially when combined with other antidiabetic medicines, characterized by dizziness, sweating, hunger pangs, dry mouth, or palpitations. Other common side effects include changes in taste (metallic taste), nausea, diarrhea, stomach pain, headache, vomiting, constipation, and upper respiratory symptoms.
  • Serious (Rare): Lactic acidosis (signs include muscle pain/weakness, difficulty breathing, persistent nausea/vomiting, stomach pain, slow heart rate) and pancreatitis. Long-term use may also lead to Vitamin B12 deficiency.
• Precautions
  • Inform your doctor if you have a history of kidney, liver, or heart disease, or pancreatic issues.
  • Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
  • Not recommended for Type 1 diabetes, diabetic ketoacidosis, or severe kidney or liver impairment.
  • Pregnant or breastfeeding women should consult their doctor before use.
  • Do not stop taking the medicine without consulting your doctor.
• Storage
  • Store below 25°C or 30°C.
  • Keep out of reach of children.

Here are some frequently asked questions about TRAJENTA DUO 2.5 MG/500 MG TABLET:

What is TRAJENTA DUO 2.5 MG/500 MG TABLET used for?

TRAJENTA DUO 2.5 MG/500 MG TABLET is a combination medicine used as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It is prescribed when treatment with both linagliptin and metformin is considered appropriate.

How does TRAJENTA DUO 2.5 MG/500 MG TABLET work?

This medication contains two active ingredients: linagliptin and metformin. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the release of insulin from the pancreas and reducing the amount of sugar produced by the liver, particularly after meals. Metformin, a biguanide, works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and improving the body's sensitivity to insulin. Together, they help prevent blood glucose levels from rising too high.

What is the usual dosage for TRAJENTA DUO 2.5 MG/500 MG TABLET?

The recommended dose is typically one tablet of 2.5 mg linagliptin/500 mg metformin hydrochloride twice daily, taken with meals. The dosage should be individualized based on the patient's current regimen, effectiveness, and tolerability, with a maximum recommended daily dose of 5 mg of linagliptin and 2000 mg of metformin. Taking it with food helps reduce gastrointestinal side effects associated with metformin.

What are the possible side effects of TRAJENTA DUO 2.5 MG/500 MG TABLET?

Common side effects include headache, nausea, diarrhea, stomach pain, changes in taste (metallic taste), dizziness, and upper respiratory symptoms. Hypoglycemia (low blood sugar) can also occur, especially when taken with other antidiabetic medicines like insulin or sulfonylureas. A rare but serious side effect associated with metformin is lactic acidosis, which requires immediate medical attention. Long-term use may also lead to vitamin B12 deficiency.

Is TRAJENTA DUO 2.5 MG/500 MG TABLET safe during pregnancy or breastfeeding?

TRAJENTA DUO is generally considered unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. It is also unsafe to use during breastfeeding, as its components are known to pass into breast milk and may harm the baby. Consult your doctor before using this medicine if you are pregnant, planning a pregnancy, or breastfeeding.

Can TRAJENTA DUO 2.5 MG/500 MG TABLET be taken with other medications?

TRAJENTA DUO can interact with other medications. Co-administration with certain anti-diabetic medications, such as insulin or sulfonylureas, may increase the risk of hypoglycemia and may require dose adjustments. Medicines that can affect kidney function, such as NSAIDs, ACE inhibitors, angiotensin II receptor antagonists, and diuretics, may increase the risk of lactic acidosis. Rifampicin (a potent inducer of P-glycoprotein and CYP3A4) can decrease the effectiveness of linagliptin. Inform your doctor about all medications, over-the-counter drugs, and herbal preparations you are taking.

What precautions should be taken with TRAJENTA DUO 2.5 MG/500 MG TABLET?

It is important to inform your doctor if you have a history of kidney, liver, or heart disease, or any pancreatic issues. The medication is contraindicated in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis. Alcohol consumption should be avoided or limited, as it can increase the risk of low blood sugar and lactic acidosis. Regular monitoring of blood sugar levels and kidney function is recommended during treatment.

What happens if a dose of TRAJENTA DUO 2.5 MG/500 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should TRAJENTA DUO 2.5 MG/500 MG TABLET be stored?

Store TRAJENTA DUO below 25°C. Keep it in a safe place out of the reach of children. Always check the expiry date on the package and do not use the medicine after this date.