Azr 50 Mg Tablet

AZR 50 MG Tablet

Name:

• Brand Name: AZR 50 MG Tablet
• Common Name: Azathioprine

Composition: Each tablet contains 50 mg of Azathioprine as the active ingredient.

Uses: AZR 50 MG Tablet is an immunosuppressant primarily used to reduce the activity of the body's immune system. It is prescribed for:

• Organ Transplantation: To prevent the body from rejecting transplanted organs such as kidneys, liver, heart, lung, or pancreas.
• Autoimmune Diseases:
  • Rheumatoid Arthritis: To alleviate pain, stiffness, and swelling in joints and slow the progression of joint damage.
  • Systemic Lupus Erythematosus (SLE).
  • Inflammatory Bowel Disease: Including Crohn's disease and ulcerative colitis.
  • Other severe inflammatory conditions of the skin, liver, arteries, and certain blood disorders.

Dosage and Administration: AZR 50 MG Tablet should be taken orally as advised by a healthcare professional.

• It is typically taken once or twice daily.
• It can be taken with food to minimize stomach discomfort.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• The exact dose and duration of treatment will depend on the patient's medical condition, weight, and response to treatment.

Side Effects: Common Side Effects:

• Nausea, vomiting, diarrhea
• Loss of appetite
• Stomach pain or upset stomach
• Hair loss or thinning of hair
• Fatigue or weakness
• Headaches

Serious Side Effects:

• Increased risk of infections (due to suppressed immune system)
• Low blood cell counts (leukopenia, anemia, low platelet count) due to bone marrow suppression, leading to symptoms like fever with chills, sore throat, unusual bleeding or bruising.
• Liver function abnormalities or inflammation of the pancreas (pancreatitis).
• Increased risk of certain cancers, including skin cancer, lymphoma, and leukemia, with long-term use.
• Allergic reactions (rare), which may include skin rash, itching, swelling, or difficulty breathing.

Precautions:

• Contraindications: Do not take if allergic to azathioprine or any other ingredients. Not recommended during pregnancy or breastfeeding.
• Medical Conditions: Inform your doctor if you have liver or kidney disease, severe bone marrow disease, active infections, inflammation of the pancreas, or a rare genetic disorder called Lesch-Nyhan syndrome or thiopurine methyltransferase (TPMT) deficiency.
• Drug Interactions: Discuss all other medications, including over-the-counter drugs and herbal supplements, with your doctor, as interactions can occur. Specific interactions include allopurinol (increases azathioprine effect), warfarin (azathioprine may decrease its effect), and certain muscle relaxants used in surgery (tubocurarine, pancuronium, succinylcholine).
• Vaccinations: Live vaccines should be avoided while on this medication.
• Monitoring: Regular blood tests (including complete blood count, liver, and kidney function tests) are necessary to monitor for side effects and ensure proper dosing.
• Sunlight Exposure: Avoid excessive exposure to sunlight and use protective clothing and high-factor sunscreen due to an increased risk of skin cancer.
• Alcohol: Avoid alcohol consumption as it may increase dizziness.
• Contraception: Effective contraceptive methods must be used during treatment and for a specified period (e.g., up to 3 months) after completing the course.

Storage: Store AZR 50 MG Tablet below 30°C in the original package. Keep it out of the sight and reach of children and pets.

Here are frequently asked questions about AZR 50 MG TABLET (Azathioprine) by IPCA LABORATORIES LTD, along with concise answers:

What is AZR 50 MG Tablet used for?

AZR 50 MG Tablet, containing Azathioprine, is primarily used as an immunosuppressant to prevent the body from rejecting transplanted organs (such as kidneys, heart, or liver). It is also used to treat autoimmune conditions where the immune system mistakenly attacks the body's own tissues, including severe rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, and autoimmune hepatitis.

How does AZR 50 MG Tablet work?

Azathioprine works by weakening the immune system. It is a prodrug that is converted in the body into active metabolites, mainly 6-mercaptopurine (6-MP). These metabolites interfere with the synthesis of DNA and RNA, which are crucial for the proliferation of rapidly dividing immune cells (like T and B lymphocytes). This disruption suppresses the immune response, helping to prevent organ rejection or reduce inflammation in autoimmune diseases.

What is the usual dosage for AZR 50 MG Tablet?

The dosage of Azathioprine varies depending on the condition being treated and the patient's body weight. For preventing kidney transplant rejection, an initial dose of 3 to 5 milligrams (mg) per kilogram (kg) of body weight per day is typically given, followed by a maintenance dose of 1 to 3 mg/kg per day. For rheumatoid arthritis, the initial dose is usually around 1 mg/kg per day (50 to 100 mg), which may be adjusted by your doctor. The tablets are generally taken once or twice a day.

What are the possible side effects of AZR 50 MG Tablet?

Common side effects include nausea, vomiting, diarrhea, loss of appetite, and fatigue. More serious side effects can include bone marrow suppression (leading to low white blood cell counts, increasing infection risk), liver damage, pancreatitis, and an increased risk of certain cancers (like skin cancer and lymphoma). It can also increase susceptibility to infections. Regular blood tests are necessary to monitor for these serious side effects.

Is AZR 50 MG Tablet safe during pregnancy or breastfeeding?

Pregnancy: Azathioprine can cause fetal harm. While some experts believe it can be continued during pregnancy for autoimmune conditions or organ transplants if the benefits outweigh the risks, it's generally advised to discuss this thoroughly with your doctor. Use of effective birth control is crucial. Breastfeeding: The use of Azathioprine during breastfeeding is debated. Some official guidelines advise against it due to potential immunosuppressive effects on the baby. However, recent studies suggest that low levels of active metabolites are found in breast milk, and it may be considered safe for healthy, full-term babies at typical doses, with clinical monitoring of the infant. Avoiding breastfeeding for 4-6 hours after a dose may reduce infant exposure. Always consult your healthcare provider.

Can AZR 50 MG Tablet be taken with other medications?

Azathioprine can interact significantly with several medications. It should not be taken with mercaptopurine or febuxostat. If taken with allopurinol (a gout medication), the Azathioprine dose must be significantly reduced. Other medications that may interact include blood thinners (like warfarin), aminosalicylates, ACE inhibitors, methotrexate, and ribavirin. It is crucial to inform your doctor about all prescription and over-the-counter medicines, vitamins, herbal products, and other supplements you are taking.

What precautions should be taken while on AZR 50 MG Tablet?

It is very important to have regular blood tests (e.g., blood cell counts and liver function tests) to monitor for side effects and effectiveness. You should avoid contact with people who are sick or have infections, as Azathioprine can lower your immune system. Avoid live vaccines while on this medication, as they may not be effective or could cause infection. Also, use sun protection (sunscreen, protective clothing, hats) when outdoors, as there's an increased risk of skin cancer.

What happens if a dose of AZR 50 MG Tablet is missed?

If you miss a dose of AZR 50 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double or extra dose to make up for the missed one. If you frequently miss doses, discuss this with your doctor or pharmacist.

How should AZR 50 MG Tablet be stored?

AZR 50 MG tablets should be stored at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Keep the medicine in its original, tightly sealed container, away from direct heat, moisture, and light. Do not store it in damp places like a bathroom or near a kitchen sink, as heat or moisture can cause it to break down. Keep all medicines out of the reach of children.