Glucreta Gm 2/10/500 Tab

GLUCRETA GM 2/10/500 TAB

Name

Brand Name: GLUCRETA GM 2/10/500 TAB (also referred to as Glucreta GM 10 mg/2 mg/500 mg Tablet) Manufacturer: Torrent Pharmaceuticals Ltd.

Composition

GLUCRETA GM 2/10/500 TAB is a fixed-dose combination tablet containing three active ingredients:

• Dapagliflozin: 10 mg (Sodium-glucose cotransporter-2 (SGLT2) inhibitor)
• Glimepiride: 2 mg (Sulfonylurea)
• Metformin: 500 mg (Biguanide)

Uses

This medication is prescribed for the management of Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels when diet, exercise, and dual therapy are not sufficient. Its actions include enhancing insulin secretion, improving the body's response to insulin, reducing glucose production by the liver, delaying sugar absorption from the intestines, and increasing the elimination of excess glucose through urine. This helps improve glycemic control and reduce the risk of diabetes-related complications.

Dosage and Administration

GLUCRETA GM 2/10/500 TAB should be taken orally with meals, typically once daily, or as directed by a healthcare provider. It is important to follow the prescribed dosage and not exceed it without consulting a doctor.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood sugar)
• Nausea, vomiting, abdominal pain
• Headache, dizziness
• Increased urination
• Genital fungal infections, urinary tract infections

Serious Side Effects:

• Lactic acidosis (a rare but serious condition due to metformin accumulation)
• Severe urinary tract infections
• Allergic reactions (e.g., swelling, skin rashes)

Precautions

• Allergies: Avoid if allergic to dapagliflozin, glimepiride, metformin, or any components of the tablet.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding; consult a doctor.
• Alcohol: Limit alcohol consumption as it may increase the risk of hypoglycemia and lactic acidosis.
• Organ Impairment: Use with caution in patients with liver or severe kidney problems; dose adjustments or alternative treatments may be necessary.
• Children: Not recommended for use in children under 18 years of age.
• Drug Interactions: Inform your doctor about all medications, herbs, and supplements being taken, especially diuretics, insulin secretagogues (e.g., gliclazide), beta-blockers, ACE inhibitors, and corticosteroids, as interactions can occur.

Storage

Store in a cool, dry place, away from direct sunlight and moisture. Keep the medicine in its original packaging and out of the sight and reach of children. Recommended storage temperature is below 30°C or between 10ºC to 25ºC.

GLUCRETA GM 2/10/500 TAB by TORRENT PHARMA is a combination medication containing Dapagliflozin (10mg), Glimepiride (2mg), and Metformin (500mg). It is used to manage type 2 diabetes mellitus in adults.

Here are some frequently asked questions about GLUCRETA GM 2/10/500 TAB:

What is GLUCRETA GM 2/10/500 TAB used for?

GLUCRETA GM 2/10/500 TAB is primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is prescribed when diet and exercise alone, or other single medications, are not sufficient to control blood sugar. This medicine helps to reduce the risk of serious diabetes complications like kidney damage, vision problems, nerve issues, and heart-related problems.

How does GLUCRETA GM 2/10/500 TAB work?

This medicine combines three active ingredients that work together to control blood sugar:

• Dapagliflozin (10mg): This component works by causing the kidneys to remove more glucose from the body through urine.
• Glimepiride (2mg): This stimulates the pancreas to produce more insulin, a natural hormone that helps move glucose from the bloodstream into cells for energy. It also helps the body use insulin more efficiently.
• Metformin (500mg): This helps to control the amount of glucose in your blood by decreasing the amount of glucose absorbed from food and the amount produced by your liver. It also improves the body's response to insulin.

What is the usual dosage for GLUCRETA GM 2/10/500 TAB?

The dose of GLUCRETA GM 2/10/500 TAB is determined by your doctor, based on your blood glucose levels and how you respond to the treatment. It is usually taken once daily with food, preferably with the first meal of the day, to help reduce stomach upset and the risk of low blood sugar. You should take it at the same time every day to maintain consistent blood levels and not stop taking it without consulting your doctor.

What are the possible side effects of GLUCRETA GM 2/10/500 TAB?

Common side effects may include hypoglycemia (low blood glucose level), dizziness, weakness, headache, nausea, vomiting, abdominal pain, and increased urination. Some individuals may also experience genital fungal infections. Serious side effects, though rare, can include lactic acidosis (a life-threatening buildup of lactic acid in the blood) and severe urinary tract infections. You should consult your doctor if side effects persist or worsen, or if you experience any serious symptoms.

Is GLUCRETA GM 2/10/500 TAB safe during pregnancy or breastfeeding?

GLUCRETA GM 2/10/500 TAB may be unsafe to use during pregnancy, and animal studies have shown harmful effects on developing babies. Information regarding its use during breastfeeding is not available, but it is generally not recommended. Always consult your doctor if you are pregnant, planning pregnancy, or breastfeeding, as they will weigh the potential benefits against any risks and may suggest alternative treatments.

Can GLUCRETA GM 2/10/500 TAB be taken with other medications?

GLUCRETA GM 2/10/500 TAB can interact with other medications. For instance, diuretics (like furosemide or hydrochlorothiazide) may increase the risk of volume depletion. Other anti-diabetic medications (like insulin or gliclazide) may increase the risk of low blood sugar. Corticosteroids (like prednisolone) may reduce the blood glucose-lowering effect. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken with GLUCRETA GM 2/10/500 TAB?

Before taking this medicine, inform your doctor if you have any kidney or liver problems, a history of bladder cancer, or a urinary tract infection. Caution is advised with alcohol consumption, as it can increase the risk of low blood sugar and lactic acidosis. Stay hydrated to prevent dehydration, as this medicine can increase urination. Regularly monitor your blood sugar levels as advised by your doctor. It is not recommended for use in children below 18 years of age.

What happens if a dose of GLUCRETA GM 2/10/500 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, and do not change the dose or stop the medication without talking to your doctor.

How should GLUCRETA GM 2/10/500 TAB be stored?

Store GLUCRETA GM 2/10/500 TAB in a cool, dry place away from direct sunlight and moisture, preferably below 30°C. Keep it in its original packaging and out of the reach of children. Do not use the medicine after the expiry date printed on the package.