Tolaz La 210mg Inj

TOLAZ LA 210MG INJ

Name

• Brand Name: TOLAZ LA 210MG INJ, Tolaz LA 210 mg Convenience Kit
• Common Name: Olanzapine Long-Acting Injection

Composition

• Active Ingredient: Olanzapine 210 mg

Uses

TOLAZ LA 210MG INJ is a potent antipsychotic medicine used for the treatment of certain mood disorders. It is prescribed for:

• Schizophrenia and its associated symptoms, including rapid control of agitation and disturbed behavior when oral therapy is not appropriate.
• Manic or mixed episodes associated with Bipolar I Disorder. It helps in improving thinking, mood, and behavior by restoring the balance of chemical messengers in the brain, and can lessen hallucinations.

Dosage and Administration

TOLAZ LA 210MG INJ is administered as an intramuscular injection into the buttock region by a healthcare professional. It is crucial not to self-administer this medication. The doctor will determine the correct dose and duration based on the patient's age, body weight, and medical condition. It should not be discontinued without consulting a prescriber.

Side Effects

Common Side Effects:

• Weight gain (especially among young adults)
• Sleepiness/Drowsiness
• Orthostatic hypotension (sudden lowering of blood pressure on standing), dizziness
• Headache
• Dry mouth
• Injection site pain, redness, or swelling
• Increase in body fat and cholesterol
• Increased prolactin level in blood
• Constipation, stomach pain, abdominal distension
• Uncontrolled muscle movements (dyskinesias, tremors, shaking)
• Nausea, vomiting, diarrhea
• Running nose and cough
• Loss of libido/sexual dysfunctions

Serious Side Effects (Seek immediate medical attention if experienced):

• Increased risk of death in elderly patients with dementia-related psychosis.
• Excessive sleepiness, dizziness, confusion, disorientation, difficulty talking and walking, muscle stiffness or shaking, weakness, irritability, aggression, anxiety, increase in blood pressure, or convulsions.
• Unusual movement of face or tongue (Tardive Dyskinesia).
• Blood clots in the veins, especially in the legs (swelling, pain, and redness), which may travel to the lungs causing chest pain and difficulty breathing.
• Significantly elevated blood sugar levels (diabetes) or high fat levels in the blood.

Precautions

• Age Restrictions: Not recommended for individuals below 13 years of age. Use with caution in elderly patients and not recommended for elderly patients above 75 years of age with dementia.
• Pregnancy and Breastfeeding: Use with caution during pregnancy, only if benefits outweigh the risks. Not recommended for use in breastfeeding women as it can pass into breast milk.
• Alcohol: Avoid alcohol consumption as it can increase drowsiness and dizziness.
• Driving and Operating Machinery: Avoid driving or operating heavy machinery as it can cause drowsiness and dizziness.
• Pre-existing Conditions: Inform your doctor if you have a history of:
  • Diabetes mellitus (close monitoring of blood sugar is recommended).
  • Heart problems, including hemodynamic instability, chest pain, or a history of allergic reactions to Olanzapine.
  • Liver or kidney diseases.
  • Seizure disorders.
  • Glaucoma or other eye problems.
  • Blood clotting issues or stroke.
  • Parkinson's disease.
  • Enlarged prostate or intestinal problems.
  • Breast cancer or other prolactin-dependent tumors.
• Drug Interactions: Inform your doctor about all medications you are taking, as Olanzapine can interact with CYP1A2 inhibitors (e.g., fluvoxamine), CNS depressants (e.g., alcohol, benzodiazepines), antihypertensives, levodopa, and dopamine agonists. Activated charcoal can decrease the absorption of olanzapine.
• Food Interactions: Take Tolaz LA 210MG INJ before food; if advised to take after food, maintain a sufficient time gap. Avoid grapefruit and grapefruit juice.

Storage

Store in a cool and dry place, away from sunlight and moisture. Keep out of sight and reach of children. Store below 30°C and protect from light. Do not use after the expiry date.

TOLAZ LA 210MG INJ by TORRENT PHARMACEUTICALS LTD is an injectable medication containing Olanzapine, an atypical antipsychotic. It is primarily used to manage schizophrenia and bipolar I disorder, specifically for agitation associated with these conditions.

What is TOLAZ LA 210MG INJ used for?

TOLAZ LA 210MG INJ is used for the treatment of schizophrenia and bipolar I disorder, including the rapid control of agitation and disturbed behavior when oral therapy is not appropriate. It can also be used in combination with other medications to treat depression.

How does TOLAZ LA 210MG INJ work?

This medicine contains Olanzapine, which is an atypical antipsychotic. It works by restoring the balance of certain chemical messengers in the brain, specifically dopamine and serotonin. This action helps to improve thinking, mood, and behavior, reducing symptoms like hallucinations, delusions, and disorganized thought.

What is the usual dosage of TOLAZ LA 210MG INJ?

TOLAZ LA 210MG INJ is administered by a healthcare professional as an injection into the muscle (intramuscularly), typically in the buttock region. The doctor will determine the correct dose and duration based on the patient's age, body weight, and specific condition. It is not to be self-administered.

What are the possible side effects of TOLAZ LA 210MG INJ?

Common side effects include weight gain, sleepiness, dizziness, headache, dry mouth, constipation, increased appetite, and pain or swelling at the injection site. Other possible side effects include orthostatic hypotension (a sudden drop in blood pressure when standing up), increased prolactin levels in the blood, restlessness, tremors, uncontrolled muscle movements, and changes in the levels of some blood cells.

Is TOLAZ LA 210MG INJ safe during pregnancy or breastfeeding?

TOLAZ LA 210MG INJ should be used with caution during pregnancy and only if the benefits outweigh the risks. Using it in the last three months of pregnancy may cause unwanted symptoms in the unborn baby, such as shaking, muscle stiffness or weakness, sleepiness, agitation, breathing problems, and difficulty feeding. It is generally not recommended for use in breastfeeding women as it can pass into breast milk.

Can TOLAZ LA 210MG INJ be taken with other medications?

It is crucial to inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements. TOLAZ LA 210MG INJ can interact with certain medications, including diuretics, antidepressants, tranquilizers, benzodiazepines, and some medications for Parkinson's disease (e.g., carbamazepine, fluvoxamine) and antibiotics (e.g., ciprofloxacin). Effects may be potentiated with CYP1A2 inhibitors such as fluvoxamine. Increased sedation can occur with alcohol or other CNS depressants, and there's an increased risk of hypotension with antihypertensives.

What precautions should be taken?

Avoid consuming alcohol during treatment as it can increase side effects like dizziness and drowsiness. Do not drive or operate machinery if you experience drowsiness or dizziness. Inform your doctor if you have a history of allergies to Olanzapine, Alzheimer's disease, liver or kidney diseases, heart problems, breathing problems, high cholesterol, glaucoma, diabetes, breast cancer, enlarged prostate, seizures, or blood clotting issues. This medicine is not recommended for individuals under 13 years of age or for elderly patients above 75 years, especially those with dementia-related psychosis, due to an increased risk of serious side effects, including death. Regular monitoring of weight, blood sugar, and cholesterol levels is recommended.

What happens if a dose is missed?

Since TOLAZ LA 210MG INJ is administered by a healthcare professional, a missed dose is unlikely. If you are concerned about a missed dose, contact your healthcare provider for instructions. Do not stop taking this medication abruptly without consulting your doctor, as sudden discontinuation can lead to unpleasant withdrawal symptoms like sweating, insomnia, tremor, anxiety, nausea, or vomiting, and may worsen your symptoms.

How should it be stored?

TOLAZ LA 210MG INJ should be stored at room temperature, away from the reach of children or pets, and protected from light. The kit should be stored according to the recommended storage conditions listed on the package insert to maintain the medication's consistency and effectiveness.