Trazine S Tablet (10 Tab)

TRAZINE S TABLET (10 TAB) by SUN PHARMA LABORATORIES LTD.

Name

• Common Name: TRAZINE S TABLET
• Brand Name: TRAZINE S TABLET (10 TAB)

Composition

TRAZINE S TABLET is a combination medication containing two active ingredients:

• Trifluoperazine (5mg): A typical antipsychotic that primarily works by inhibiting dopamine receptors in the brain. Dopamine is a chemical messenger involved in regulating mood, behavior, and emotions, and blocking its action helps control psychotic illness, relieve depression, lighten mood, and alleviate anxiety symptoms.
• Trihexyphenidyl (2mg): An anticholinergic/antispasmodic agent that is added to prevent and manage involuntary movements, muscle spasms, and shaking often associated with Trifluoperazine. It works by affecting acetylcholine receptors to improve muscle control and reduce stiffness.

Uses

TRAZINE S TABLET is prescribed for the treatment and management of various mental health conditions and associated symptoms, including:

• Schizophrenia: To manage its positive and negative symptoms and prevent relapses.
• Anxiety: For short-term relief of symptoms like fear and panic.
• Depression: To alleviate symptoms and lighten mood over a short period.
• Parkinson's Disease: To reduce involuntary movements associated with the condition.
• Neurosis and Extrapyramidal Symptoms caused by other medications.

Dosage and Administration

• TRAZINE S TABLET should be taken strictly as prescribed by your physician.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It can be taken with or without food, preferably at the same time each day to maintain a consistent level of medicine in the body.
• Do not discontinue the medication suddenly without consulting your doctor, as this may worsen symptoms or lead to withdrawal effects.
• For schizophrenia, a typical adult dosage might be one tablet daily, but this should be determined by your doctor based on your medical condition.

Side Effects

Common side effects may include:

• Nausea, constipation, dry mouth
• Sedation, drowsiness, dizziness
• Weight gain
• Blurred vision, nervousness, headache
• Orthostatic hypotension (sudden drop in blood pressure upon standing)
• Urinary retention, increased prolactin levels in the blood, abnormal heart rhythm, muscle spasm, tremor, restlessness, confusion.

Serious side effects, though less common, can include severe tremors, muscle spasms, neuroleptic malignant syndrome (characterized by fever, altered mental status, and muscle stiffness), or tardive dyskinesia (involuntary movements of the face). Seek immediate medical attention if these occur.

Precautions

• Allergies: Do not take if you have a known allergy to Trifluoperazine, Trihexyphenidyl, or any other components of the tablet.
• Pregnancy: TRAZINE S TABLET is generally not recommended during pregnancy, especially in the third trimester, as it may harm the baby. Consult your doctor if you are pregnant or planning to conceive.
• Breastfeeding: It is likely unsafe during breastfeeding. Consult your doctor if you are a nursing mother.
• Elderly Patients: Use with caution in patients over 65 years, as there is an increased risk of adverse reactions. Dose adjustments may be necessary.
• Alcohol Consumption: Avoid alcohol while on this medication, as it can intensify drowsiness and dizziness.
• Driving & Operating Machinery: TRAZINE S TABLET can cause dizziness, drowsiness, and blurred vision. Avoid driving or operating heavy machinery until you understand how the medicine affects you.
• Pre-existing Medical Conditions: Inform your doctor if you have glaucoma, prostate problems, urination issues, stomach ulcers, acidity, myasthenia gravis, tardive dyskinesia, alcoholism, high blood pressure, heart, liver, kidney disease, seizure disorder, infectious diarrhea, or dementia.
• Heat Sensitivity: This medicine may reduce sweating, increasing the risk of heatstroke. Drink plenty of fluids and dress lightly in hot weather, avoiding strenuous activity.
• Children: TRAZINE S TABLET is not recommended for use in patients below 18 years of age.

Storage

• Keep TRAZINE S TABLET out of the sight and reach of children.
• Store at room temperature, protected from light and moisture, in its original container, tightly closed.

What is TRAZINE S TABLET used for?

TRAZINE S TABLET is a combination medicine primarily used to manage symptoms and prevent relapse in schizophrenia, a mental disorder characterized by unreal thoughts and behaviors. It is also used for the symptomatic control of all forms of Parkinson's disease, which is a neurological disorder affecting movement. Additionally, it can be used for treating anxiety and depression over a short period, and to manage extrapyramidal symptoms caused by other medicines.

How does TRAZINE S TABLET work?

TRAZINE S TABLET contains two active ingredients: Trifluoperazine and Trihexyphenidyl (also known as Benzhexol). Trifluoperazine is a typical antipsychotic that works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts, mood, and behavior. This helps to control psychotic symptoms, alleviate depression, and improve mood. Trihexyphenidyl is an antimuscarinic (anticholinergic) agent added to prevent and manage involuntary movements like shaking of hands and muscle spasms, which can be a side effect of Trifluoperazine. It acts by correcting chemical imbalances in the brain responsible for these side effects and also helps improve muscle control and reduce stiffness.

What is the usual dosage of TRAZINE S TABLET?

The dosage of TRAZINE S TABLET should be strictly as prescribed by your doctor, as it varies based on the patient's age, weight, health condition, and the specific condition being treated. For schizophrenia, a common adult starting dose mentioned is 2-5 mg twice daily. It is generally recommended to take the tablet whole with a glass of water, preferably at the same time each day to maintain a consistent level of medicine in the body. It can be taken with or without food, but consistency is advised.

What are the possible side effects of TRAZINE S TABLET?

Many side effects are usually temporary and resolve as your body adjusts to the medicine. Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, constipation, nausea, weight gain, nervousness, and urinary retention. Some individuals may also experience tremors, restlessness, muscle spasms, or a sudden drop in blood pressure when changing positions (orthostatic hypotension). More serious, though less common, side effects can include neuroleptic malignant syndrome (fever, altered mental status, muscle stiffness) and tardive dyskinesia (involuntary movements of the face). If side effects persist or worsen, consult your doctor.

Is TRAZINE S TABLET safe during pregnancy or breastfeeding?

TRAZINE S TABLET is generally not recommended for use during pregnancy, especially in the third trimester, as it may cause adverse effects in the unborn baby such as breathing problems, muscle stiffness or weakness, or shaking. Animal research has shown some harmful effects in developing unborn babies. If you are pregnant or planning pregnancy, consult your doctor. For breastfeeding mothers, TRAZINE S TABLET is probably unsafe to use. Limited data suggests the medicine may pass into breast milk and harm the baby. Always consult your doctor before taking this medicine if you are breastfeeding.

Can TRAZINE S TABLET be taken with other medications?

Taking TRAZINE S TABLET with certain other medications can lead to interactions. It's crucial to inform your doctor about all medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins.

• CNS Depressants: Avoid taking with alcohol, sleeping tablets (e.g., temazepam, triazolam), anesthetics (e.g., propofol), or strong painkillers (e.g., codeine) as this can increase central nervous system depression and intensify side effects like drowsiness and dizziness.
• Antihypertensives: It can interact with high blood pressure medications and further increase blood pressure or reverse their hypotensive effect.
• Anticholinergics/Antiparkinsonian medicines: Concurrent use can increase anticholinergic effects and may lead to tardive dyskinesia.
• Antidepressants: Increased risk of side effects with certain antidepressants like phenothiazines or lithium.
• Levodopa: TRAZINE S TABLET can antagonize the effects of dopaminergic drugs like levodopa.
• Antacids: May decrease the absorption of TRAZINE S TABLET.

What precautions should be taken while taking TRAZINE S TABLET?

• Driving and Operating Machinery: This medicine can cause dizziness, drowsiness, blurred vision, and mental confusion, so avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol Consumption: Do not consume alcohol as it can exaggerate side effects like lightheadedness, nausea, vomiting, dizziness, and loss of consciousness.
• Sudden Discontinuation: Do not stop taking TRAZINE S TABLET suddenly without consulting your doctor, as it can worsen symptoms or cause withdrawal effects like sweating, nervousness, vomiting, or dizziness, and may lead to neuroleptic malignant syndrome.
• Medical Conditions: Inform your doctor if you have a history of glaucoma, prostate issues, stomach ulcers, epilepsy, Parkinson's disease, heart problems, liver or kidney disease, diabetes, or tardive dyskinesia.
• Heat Exposure: TRAZINE S TABLET can reduce sweating, increasing the risk of heatstroke. Drink plenty of fluids and dress lightly in hot weather.
• Elderly Patients: Use with caution in elderly patients (above 65 years) as they may have an increased risk of adverse reactions.
• Children: Not recommended for use in children below 18 years of age without consulting a doctor, as its safety and efficacy are not clinically established in this age group.

What happens if a dose of TRAZINE S TABLET is missed?

If you miss a dose of TRAZINE S TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should TRAZINE S TABLET be stored?

TRAZINE S TABLET should be stored in its original container, tightly closed, and protected from light and moisture. Keep it out of the sight and reach of children. Dispose of any unused medicine safely according to local guidelines.