Rabezol Dsr Capsule (10 Cap)

RABEZOL DSR CAPSULE

Rabezol DSR Capsule is a combination medication manufactured by Aristo Pharmaceuticals Private Limited. It is designed to address various digestive issues related to excess stomach acid and impaired gastrointestinal motility.

Composition

Rabezol DSR Capsule contains two active ingredients:

• Rabeprazole (20 mg): A proton pump inhibitor (PPI) that reduces stomach acid production by blocking the H+/K+-ATPase enzyme (gastric proton pump) in the stomach lining cells.
• Domperidone (30 mg): A dopamine-2 receptor antagonist that enhances the motility of the upper gastrointestinal tract and speeds up gastric emptying, while also blocking the chemoreceptor trigger zone (CTZ) to reduce nausea and vomiting.

Uses

Rabezol DSR Capsule is primarily used to treat:

• Gastroesophageal Reflux Disease (GERD) (acid reflux), especially in patients who have not responded adequately to rabeprazole alone. It helps alleviate symptoms like heartburn, acidity, indigestion, chest pain, and difficulty swallowing.
• Peptic ulcer disease, including stomach ulcers, duodenal ulcers, and those caused by H. pylori infection or NSAID use.
• Zollinger-Ellison syndrome, a condition involving the overproduction of acid due to a pancreatic tumor.
• Nausea and vomiting associated with these gastrointestinal conditions.

Dosage and Administration

It is recommended to take Rabezol DSR Capsule as advised by a doctor.

• The capsule should be swallowed whole with a glass of water, typically on an empty stomach, ideally one hour before a meal.
• Do not crush, chew, or break the capsule, as this may disrupt its sustained-release properties.
• The dosage and duration of treatment are determined by the physician based on the patient's age, body weight, and medical condition.
• Do not stop taking the medication without consulting a doctor, as symptoms may recur.

Side Effects

Common side effects may include:

• Headache
• Diarrhea
• Nausea, vomiting
• Abdominal pain, flatulence
• Dizziness, weakness
• Dry mouth
• Joint pain (arthralgia)

Serious side effects, though less common, warrant immediate medical attention:

• Severe allergic reactions (e.g., sudden wheezing, swelling of lips, face, body, rash, difficulty swallowing)
• Symptoms of liver problems (e.g., yellow skin, dark urine, tiredness)
• Severe skin reactions (e.g., erythema multiforme, Stevens-Johnson syndrome)
• Seizures

Precautions

• Allergies: Contraindicated if allergic to rabeprazole, domperidone, or any of its ingredients.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding. Consult a doctor to weigh benefits and risks.
• Liver and Kidney Disease: Use with caution in patients with liver or kidney problems; contraindicated in moderate or severe liver impairment and severe heart problems.
• Heart Conditions: Contraindicated in individuals with a history of cardiac arrhythmias (e.g., ventricular fibrillation, QT prolongation) or those taking medications that prolong the QT interval.
• Long-term Use: Prolonged intake (more than three months or a year) may lead to deficiencies of Vitamin B12, magnesium, calcium, and Vitamin D, potentially increasing the risk of bone fractures. Regular monitoring by a doctor may be necessary.
• Other Interactions: Inform your doctor about all other medications, supplements, and herbal products being taken to prevent potential drug interactions (e.g., with blood thinners, antifungals, anti-HIV drugs, iron supplements, methotrexate, digoxin, erlotinib, atazanavir).
• Alcohol and Smoking: Avoid alcohol and smoking as they can worsen acid reflux symptoms and cause serious side effects.
• Driving: May cause dizziness, sleepiness, or blurred vision, so avoid driving or operating heavy machinery if these symptoms occur.
• Children: Not recommended for children below 18 years of age due to lack of safety and effectiveness data.

Storage

Store Rabezol DSR Capsule in a cool, dry place, protected from direct sunlight and moisture. Keep the medicine out of reach of children. Store below 25°C or 30°C.

RABEZOL DSR CAPSULE (10 CAP) by ARISTO PHARMACEUTICALS PRIVATE LIMITED is a combination medication containing Rabeprazole and Domperidone, commonly prescribed for various gastrointestinal conditions.

What is Rabezol DSR Capsule used for?

Rabezol DSR Capsule is primarily used to treat symptoms of acid reflux due to hyperacidity, gastroesophageal reflux disease (GERD), stomach ulcers (peptic ulcer disease), and Zollinger-Ellison syndrome (a condition causing overproduction of acid due to a pancreatic tumor). It helps alleviate symptoms such as heartburn, acidity, indigestion, chest pain, difficulty swallowing, nausea, and vomiting. It can also aid in healing duodenal ulcers and protecting the digestive tract lining.

How does it work?

Rabezol DSR Capsule contains two active ingredients: Rabeprazole and Domperidone.

• Rabeprazole is a proton pump inhibitor (PPI). It works by blocking the action of an enzyme called the gastric proton pump (H+/K+ ATPase) in the stomach lining cells, which is responsible for secreting stomach acid. This prevents the release of stomach acid, thereby reducing the overall acid production and relieving acid-related symptoms.
• Domperidone is a prokinetic agent and a dopamine-2 receptor antagonist. It increases the motility of the upper gastrointestinal tract and speeds up gastric emptying, allowing food to move more easily through the stomach. It also blocks the vomiting-inducing center (chemoreceptor trigger zone - CTZ), helping to control nausea and vomiting.

What is the usual dosage?

Rabezol DSR Capsule should be taken as advised by your doctor, usually once daily. It is generally recommended to take it one hour before a meal, preferably in the morning, as food can interact with its absorption. The capsule should be swallowed whole with a glass of water and not crushed, chewed, or broken. Your doctor will determine the correct dosage and duration based on your medical condition.

What are the possible side effects?

Common side effects of Rabezol DSR Capsule may include headache, diarrhea, nausea, abdominal pain, vomiting, dizziness, dryness in the mouth, and flatulence. These side effects are usually temporary and may resolve over time. More serious but rare side effects can include severe allergic reactions, symptoms of liver problems, severe skin reactions, and seizures. Long-term use may also lead to deficiencies in Vitamin B12 and magnesium, and an increased risk of osteoporosis or fractures. If you experience persistent or severe side effects, consult your doctor.

Is it safe during pregnancy or breastfeeding?

Rabezol DSR Capsule is generally not recommended for use during pregnancy. While some sources suggest it may be safe, it's crucial to inform your doctor if you are pregnant or planning to conceive, as the components may harm the unborn baby. Similarly, for breastfeeding, components of Rabezol DSR Capsule pass into breast milk in small amounts and might affect the baby. It is contraindicated for breastfeeding women by some sources. Always consult your doctor to weigh the benefits and potential risks before taking this medicine while pregnant or breastfeeding.

Can it be taken with other medications?

Rabezol DSR Capsule can interact with various medications. It may interact with blood thinners (e.g., warfarin, clopidogrel), antifungals (e.g., ketoconazole, itraconazole, fluconazole), anti-HIV drugs (e.g., rilpivirine), iron supplements, and anti-cancer medications (e.g., methotrexate). Heart medications like digoxin and quinidine can also interact. It is essential to inform your doctor about all medicines, including supplements and herbal products, you are taking to prevent potential interactions.

What precautions should be taken?

Inform your doctor if you have any history of gastric cancer, liver disease, kidney problems, serious heart problems (like heart failure, heart rhythm problems, or electrolyte imbalance), low magnesium levels, or low vitamin B1. Prolonged intake may lead to lupus erythematosus, vitamin B12, and magnesium deficiency, and increase the risk of osteoporosis. Avoid consuming alcohol and smoking, as they can worsen acid reflux and cause serious side effects. Do not drive or operate heavy machinery if you experience dizziness, sleepiness, or blurred vision. It is not recommended for children below 16 or 18 years of age depending on the source.

What happens if a dose is missed?

If you miss a dose of Rabezol DSR Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

Rabezol DSR Capsule should be stored in a cool and dry place, ideally at room temperature (below 25°C or 30°C), protected from moisture and direct sunlight. Keep the medicine out of reach of children. Always check the expiry date and discard the medicine if it has expired.