Repace H Tablet (10 Tab)

REPACE H TABLET

REPACE H TABLET is a medication manufactured by SUN PHARMA LABORATORIES LTD., primarily prescribed for the management of hypertension (high blood pressure). It is also used to reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy.

• Composition Each tablet contains a combination of two active ingredients:

  • Losartan Potassium (50 mg)
  • Hydrochlorothiazide (12.5 mg)

  Losartan is an angiotensin II receptor blocker (ARB) that works by relaxing and widening blood vessels, allowing blood to flow more easily. Hydrochlorothiazide is a diuretic (water pill) that helps the body eliminate excess salt and water through increased urine production, which further contributes to lowering blood pressure.

• Uses REPACE H TABLET is used for:

  • Reducing high blood pressure levels (hypertension).
  • Managing fluid build-up and swelling (oedema) caused by heart, kidney, or liver diseases.
  • Protecting the kidneys from damage in diabetic patients.
  • Decreasing the risk of strokes in individuals with left ventricular hypertrophy.

• Dosage and Administration The typical dosage guidance is one tablet once daily, preferably at the same time each day. It can be taken with or without food, swallowed whole with a glass of water. Dosage may vary based on the severity of the condition and patient response, and it is crucial not to exceed the prescribed dose without consulting a doctor. For severe hypertension, the starting dose is usually 50/12.5 mg once daily, which may be increased to 100/25 mg once daily if the response is inadequate after 2 to 4 weeks. The maximum dose is 100/25 mg once daily.

• Side Effects Common side effects may include:

  • Dizziness or lightheadedness
  • Fatigue or weakness
  • Nausea
  • Diarrhea
  • Headache
  • Back pain
  • Decreased blood pressure
  • Increased blood uric acid or lipid levels

  Serious side effects, though rare, can include severe allergic reactions, severe low blood pressure, and kidney problems.

• Precautions

  • Allergies: Avoid use if allergic to Losartan, Hydrochlorothiazide, or any other ingredients.
  • Pregnancy and Breastfeeding: REPACE H TABLET is contraindicated during pregnancy, particularly in the second and third trimesters, due to risks to the developing baby. It is also generally advised to avoid during breastfeeding.
  • Alcohol Consumption: Caution is advised with alcohol, as it may enhance side effects like dizziness and further lower blood pressure.
  • Medical Conditions: Use with caution in patients with a history of liver disease, kidney problems (especially severe renal impairment), diabetes, and gout.
  • Other Medications: Consult a doctor before taking with other blood pressure-lowering drugs, diuretics, lithium, or potassium supplements.
  • Photosensitivity: The medicine may cause photosensitivity, so avoid excessive sun exposure.
  • Driving/Operating Machinery: May cause dizziness, affecting alertness, vision, or causing sleepiness.

• Storage Store REPACE H TABLET in a closed container at room temperature, below 30°C. Protect the medication from excessive light and moisture, and keep it out of reach of children.

What is Repace H Tablet used for?

Repace H Tablet is primarily used to treat high blood pressure, also known as hypertension. It is often prescribed when a single medicine is not sufficient to control blood pressure effectively. Additionally, it helps to manage fluid retention and swelling (oedema) caused by heart, kidney, or liver diseases. The medication also aids in protecting the kidneys from damage in individuals with diabetes and can reduce the risk of strokes in patients with left ventricular hypertrophy (enlarged heart muscle).

How does Repace H Tablet work?

Repace H Tablet is a combination medication containing Losartan (50 mg) and Hydrochlorothiazide (12.5 mg). Losartan is an angiotensin II receptor blocker (ARB) that works by relaxing and widening blood vessels, which allows blood to flow more easily and lowers blood pressure. Hydrochlorothiazide is a diuretic, also known as a "water pill," which increases the production of urine to help the body eliminate excess salt and water. This reduction in fluid volume within the blood vessels further contributes to lowering blood pressure.

What is the usual dosage of Repace H Tablet?

The typical dosage of Repace H Tablet is one tablet once daily, but your doctor will determine the specific dose and frequency based on your individual medical condition and how you respond to the medication. It is crucial to follow your doctor's instructions and not to exceed the prescribed dosage. For severe hypertension, the starting dose is usually one 50/12.5 mg tablet once daily, which may be increased to 100/25 mg once daily if the response is inadequate after 2 to 4 weeks.

What are the possible side effects of Repace H Tablet?

Common side effects of Repace H Tablet may include dizziness, feeling tired, nausea, diarrhea, headache, back pain, and cold/flu-like symptoms such as a cough. Some individuals might also experience stomach upset, taste changes, or weakness. Infrequent urination is a normal effect of the diuretic component and not a side effect. Most side effects are usually mild and resolve over time. However, if any side effects are persistent or worsen, you should consult your doctor.

Is Repace H Tablet safe during pregnancy or breastfeeding?

No, Repace H Tablet is considered unsafe during pregnancy, especially in the second and third trimesters, as it can cause harm or even death to the developing baby. If you become pregnant while taking this medication, stop using it immediately and contact your doctor. It is also generally advised to avoid Repace H Tablet while breastfeeding, especially with premature babies, as information on its use in breastfeeding is limited and it may pass into breast milk with unknown effects on the baby. Alternative treatment options with better-established safety profiles are available for breastfeeding mothers.

Can Repace H Tablet be taken with other medications?

Repace H Tablet can interact with various medications. It is important to inform your doctor about all the medicines, supplements, or herbal preparations you are taking. Interactions can occur with:

• Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen): These can reduce the blood pressure-lowering effect and increase the risk of kidney damage.
• Potassium supplements or salt substitutes containing potassium: These can increase the risk of high potassium levels in your blood (hyperkalemia).
• Insulin and oral antidiabetic medications: Repace H Tablet can affect blood glucose levels, potentially reducing the effectiveness of these medications.
• Blood thinners (e.g., warfarin, heparin), anti-cancer medicines, cholesterol-lowering medicines (e.g., cholestyramine), and antidepressants (e.g., lithium).
• Other anti-hypertensives like water pills (furosemide) and medicines for heart-related disorders like digoxin.
• Aliskiren: Should not be taken with Repace H Tablet if you have diabetes.
• Steroidal medicines: Can lead to electrolyte imbalances, particularly reduced potassium levels.

What precautions should be taken while using Repace H Tablet?

Several precautions should be observed when taking Repace H Tablet. Avoid consuming alcohol as it can intensify some side effects like dizziness and may cause a significant drop in blood pressure. Limit sun exposure as the medicine may cause photosensitivity. Regular monitoring of blood pressure, kidney function, and electrolyte levels (especially potassium) is recommended. If you have a history of liver disease, kidney problems, diabetes, or gout, use this medicine with caution and under your doctor's supervision, as it can impact these conditions. Repace H Tablet can cause dizziness, so be cautious when driving or operating machinery, especially at the start of treatment or when the dose is increased. Avoid potassium-rich foods like bananas and oranges. Do not stop taking the medicine suddenly without consulting your doctor, as this can lead to a sudden rise in blood pressure.

What happens if a dose of Repace H Tablet is missed?

If you miss a dose of Repace H Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Repace H Tablet be stored?

Repace H Tablet should be stored in a closed container at room temperature, ideally below 30°C (86°F). Keep the medication protected from excessive light and moisture. It is crucial to keep it out of the reach of children.