Zayo 200 Tablet

ZAYO 200 TABLET is a medication manufactured by Eris Lifesciences Limited, primarily used in the management of chronic heart failure.

• Name
  • Brand Name: ZAYO 200 TABLET
  • Common Name: Sacubitril and Valsartan
• Composition Each tablet contains a combination of Sacubitril 97 mg and Valsartan 103 mg. These active ingredients belong to a class of angiotensin receptor neprilysin inhibitors (ARNI).
• Uses ZAYO 200 TABLET is prescribed for the treatment of chronic heart failure (New York Heart Association Class II-IV) with reduced ejection fraction. It aims to reduce the risk of cardiovascular death and hospitalization for heart failure. This combination works by relaxing blood vessels, making it easier for the heart to pump blood, and helping the body retain less water.
• Dosage and Administration This medication is for oral administration and is typically taken once daily, with or without food. Tablets should be swallowed whole with water and not crushed, chewed, or broken. For optimal effectiveness, it is recommended to take the tablet at the same time each day. Patients must strictly follow their doctor's dosage and duration instructions.
• Side Effects
  • Common Side Effects: Dizziness, light-headedness (low blood pressure), cough, headache, tiredness, nausea, and weakness. Other common effects include high potassium levels in the blood (hyperkalemia), decreased renal function, diarrhea, and signs of low red blood cells (anemia).
  • Serious Side Effects: Rarely, severe allergic reactions like angioedema (swelling of the face, lips, tongue, or throat) can occur, requiring immediate medical attention.
• Precautions ZAYO 200 TABLET is contraindicated in individuals with allergies to sacubitril, valsartan, or any other components. It should not be used in pregnant or breastfeeding women, especially after the first three months of pregnancy due to potential harm to the baby. Patients with severe liver disease or those taking aliskiren for diabetes or kidney disease should avoid this medicine. A gap of at least 36 hours is necessary when switching from an ACE inhibitor to ZAYO 200 TABLET. Caution is advised for patients with liver, kidney, or heart problems, and dose adjustments may be needed. Patients should inform their doctor about all current medications, including over-the-counter drugs, herbal supplements, and vitamins, to prevent drug interactions. It is recommended to avoid alcohol, potassium supplements, and potassium-rich foods.
• Storage Store ZAYO 200 TABLET in a cool, dry place, away from direct sunlight and moisture, and out of reach of children. Do not store above 30°C.

ZAYO 200 TABLET, manufactured by Eris Lifesciences Limited, is a medication primarily used for the management of chronic heart failure. It is a combination of Sacubitril and Valsartan, which work together to improve heart function.

What is ZAYO 200 TABLET used for?

ZAYO 200 TABLET is prescribed to reduce the risk of cardiovascular death and hospitalization in adult patients with long-lasting (chronic) heart failure, specifically those with New York Heart Association (NYHA) Class II-IV heart failure and reduced ejection fraction. Heart failure occurs when the heart is weak and cannot pump enough blood to the body, leading to symptoms like breathlessness, fatigue, and swelling.

How does ZAYO 200 TABLET work?

ZAYO 200 TABLET is a combination of two active ingredients: Sacubitril and Valsartan. Sacubitril belongs to a class of drugs called neprilysin inhibitors, which work by relaxing and widening the blood vessels, making it easier for the heart to pump blood. Valsartan is an angiotensin II receptor blocker (ARB) that also helps relax blood vessels by blocking the action of a substance called angiotensin-II, which normally causes blood vessels to tighten. This combined action helps lower blood pressure, improve heart function, and reduce the body's retention of water.

What is the usual dosage of ZAYO 200 TABLET?

ZAYO 200 TABLET is typically administered orally, usually once daily, and can be taken with or without food. It is crucial to follow your doctor's instructions precisely regarding the dosage and duration of treatment. The tablets should be swallowed whole with a glass of water and should not be crushed, chewed, or broken. Taking the medication at the same time each day is generally recommended to maintain a consistent level in your body.

What are the possible side effects of ZAYO 200 TABLET?

Common side effects may include dizziness, light-headedness (due to low blood pressure), cough, headache, tiredness, nausea, diarrhea, and weakness. Some patients may experience high potassium levels in the blood (hyperkalemia), which can manifest as irregular heartbeat or muscle weakness, or a decrease in kidney function.

Rare but serious side effects include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat), which can cause difficulty breathing or swallowing. If you experience any severe or persistent side effects, or signs of an allergic reaction, seek immediate medical attention.

Is ZAYO 200 TABLET safe during pregnancy or breastfeeding?

Pregnancy: ZAYO 200 TABLET is contraindicated during pregnancy. It is unsafe to use, especially after the first 3 months of pregnancy, as it can cause serious harm or even endanger the life of the developing baby. If you become pregnant while taking this medication, stop immediately and contact your doctor.

Breastfeeding: ZAYO 200 TABLET is not recommended for use by breastfeeding women. It is considered probably unsafe during breastfeeding, and you should consult your doctor if you are breastfeeding or plan to do so.

Can ZAYO 200 TABLET be taken with other medications?

It is important to inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medicines, herbal supplements, and vitamins, as ZAYO 200 TABLET can interact with certain drugs.

• Avoid:

  • Angiotensin-converting enzyme (ACE) inhibitors (e.g., enalapril, lisinopril, ramipril): Do not take ZAYO 200 TABLET for at least 36 hours before or after taking an ACE inhibitor, due to an increased risk of serious side effects like angioedema (swelling of the face, lips, tongue, or throat).
  • Aliskiren: Should not be used if you have diabetes or kidney disease and are taking aliskiren-containing blood pressure-lowering medicines.
  • Alcohol: Consuming alcohol with ZAYO 200 TABLET is not recommended, as it can increase the risk of side effects.
  • Grapefruit or grapefruit juice: Avoid consuming these as they may increase the concentration of the drug in your bloodstream.

• Use with caution/inform your doctor:

  • Other Angiotensin Receptor Blockers (ARBs) such as telmisartan or losartan.
  • Potassium supplements, potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene), salt substitutes containing potassium, or heparin, as these can increase potassium levels in your blood.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) or painkillers, especially in elderly or dehydrated patients, as they can worsen kidney function.
  • Sildenafil, as it may cause a further decrease in blood pressure.
  • Lithium.
  • Atorvastatin.

What precautions should be taken with ZAYO 200 TABLET?

Before starting treatment, inform your doctor about any pre-existing medical conditions, particularly liver or kidney problems, heart conditions, or a history of angioedema. Regular monitoring of blood pressure and kidney function is often advised during treatment. If you experience dizziness or tiredness, avoid driving or operating machinery. To reduce the chances of feeling dizzy, rise slowly when moving from a sitting or lying position. Maintaining a healthy, low-sodium diet and engaging in light physical activity is also recommended.

What happens if a dose is missed?

If you miss a dose of ZAYO 200 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can increase the risk of side effects.

How should ZAYO 200 TABLET be stored?

ZAYO 200 TABLET should be stored in a cool, dry place, away from direct sunlight and moisture. Keep the medication out of the reach of children. It should not be stored above 30°C.