Onarni 50mg Tab

ONARNI 50MG Tablet by US VITAMINS (USV) is a medication used in the management of heart failure.

Name

• Brand Name: ONARNI 50MG Tablet, OnArni
• Common Name: Sacubitril/Valsartan

Composition

Each ONARNI 50MG Tablet contains a combination of two active ingredients:

• Sacubitril (24mg)
• Valsartan (26mg)

Uses

ONARNI 50MG Tablet is primarily prescribed for the treatment of heart failure.

• It is used to treat chronic heart failure in adults and children above one year of age, particularly those with reduced ejection fraction.
• It helps to relax and widen blood vessels, making it easier for the heart to pump blood throughout the body.
• The medicine aims to reduce the risk of hospitalization and death in patients with chronic heart failure.
• It also contributes to hypertension management and cardiovascular protection.

Dosage and Administration

• The typical starting dose for most patients is one 50mg tablet once a day, or as prescribed by a physician.
• The tablet can be taken with or without food.
• It should be swallowed whole with a glass of water; do not chew, crush, or break the tablet.
• It is important to adhere to the prescribed dosage and avoid exceeding it.

Side Effects

Common side effects may include:

• Dizziness, lightheadedness, or fainting
• Low blood pressure (hypotension)
• Cough
• Nausea, diarrhea, and weakness
• Elevated potassium levels in the blood (hyperkalemia)
• Fatigue or headache
• Renal impairment or kidney dysfunction
• Serious allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat) are rare but require immediate medical attention.

Precautions

• Allergies: Do not take if allergic to Sacubitril, Valsartan, or any components of the tablet.
• Drug Interactions:
  • Avoid concomitant use with ACE inhibitors (e.g., captopril, enalapril) due to an increased risk of angioedema. A washout period of at least 36 hours is required before or after taking an ACE inhibitor.
  • Concomitant use with other Angiotensin Receptor Blockers (ARBs) can increase the risk of hyperkalemia and renal impairment.
  • Potassium-sparing diuretics may increase blood potassium levels.
• Pregnancy and Breastfeeding: ONARNI 50MG Tablet is contraindicated during pregnancy and not recommended for breastfeeding women.
• Medical Conditions: Inform your doctor if you have kidney or liver diseases, a history of angioedema, low blood pressure, vomiting, or diarrhea.
• Driving: This medicine may cause dizziness, so avoid driving or operating heavy machinery if you experience this side effect.
• Diet: Limit salt intake and avoid potassium supplements or potassium-rich foods unless advised by your doctor, as the medicine can affect potassium levels.
• Alcohol: Consult your doctor regarding alcohol consumption as it can further lower blood pressure.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep the medicine out of the sight and reach of children.
• It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

ONARNI 50MG Tablet is a combination medication containing Sacubitril and Valsartan. It is primarily used to treat chronic heart failure with reduced ejection fraction, a condition where the heart cannot pump blood effectively.

Here are some frequently asked questions about ONARNI 50MG Tablet:

What is ONARNI 50MG Tablet used for?

ONARNI 50MG Tablet is used to treat long-lasting (chronic) heart failure in adults, particularly when the heart's pumping ability is reduced. It helps to improve heart function, reduce symptoms like breathlessness and fatigue, and lower the risk of hospitalization and cardiovascular death in patients with heart failure. It may also be used to manage hypertension (high blood pressure) and provide cardiovascular protection by reducing the risk of heart attacks and strokes.

How does ONARNI 50MG Tablet work?

ONARNI 50MG Tablet is a combination of two medicines: sacubitril and valsartan. Sacubitril works by inhibiting an enzyme called neprilysin, which helps to relax and widen blood vessels and promotes the excretion of sodium and water from the body. Valsartan is an angiotensin receptor blocker (ARB) that works by blocking the effects of angiotensin II, a substance that constricts blood vessels. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood throughout the body, reducing strain on the heart, and improving heart function.

What is the usual dosage for ONARNI 50MG Tablet?

The recommended starting dose for most patients is one 50mg tablet once a day. However, your doctor may adjust the dosage based on your specific medical condition and how you respond to the medication. It should be swallowed whole with a glass of water and can be taken with or without food, preferably at the same time each day for optimal results.

What are the possible side effects of ONARNI 50MG Tablet?

Common side effects include dizziness, lightheadedness, fatigue, low blood pressure (hypotension), elevated potassium levels in the blood (hyperkalemia), cough, and impaired kidney function. If these or any other side effects become severe or persist, it's important to consult your doctor.

Is ONARNI 50MG Tablet safe during pregnancy or breastfeeding?

No, ONARNI 50MG Tablet is not recommended for use during pregnancy as it can harm the fetus and is contraindicated, especially after the first three months of pregnancy. It is also not recommended for use in breastfeeding women. Your doctor will discuss safer alternatives if you are pregnant or breastfeeding.

Can ONARNI 50MG Tablet be taken with other medications?

ONARNI 50MG Tablet can interact with several other medications. It should not be taken with ACE inhibitors (e.g., enalapril, lisinopril) or other Angiotensin Receptor Blockers (ARBs) due to an increased risk of side effects like angioedema (swelling of the face, lips, tongue, or throat) and hyperkalemia. A waiting period of at least 36 hours is required before or after taking an ACE inhibitor. Concomitant use with aliskiren (especially in patients with diabetes or kidney disease), potassium-sparing diuretics (e.g., spironolactone), potassium supplements, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), and lithium may also increase the risk of adverse effects or reduce the effectiveness of ONARNI 50MG Tablet. Always inform your doctor about all medications, herbal preparations, and supplements you are currently taking.

What precautions should be taken while taking ONARNI 50MG Tablet?

Precautions include informing your doctor if you have a history of angioedema, kidney or liver disease, low blood pressure, vomiting, diarrhea, or dehydration. It is advisable to avoid or limit alcohol consumption as it can further lower blood pressure and worsen dizziness. You should also avoid potassium supplements and potassium-rich foods (like bananas and broccoli) as this medication can increase potassium levels in your blood. Do not drive or operate heavy machinery if you experience dizziness or fatigue.

What happens if a dose of ONARNI 50MG Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ONARNI 50MG Tablet be stored?

ONARNI 50MG Tablet should be stored in a cool, dry place at room temperature (below 30°C or between 10ºC to 25ºC), away from direct sunlight and moisture. Keep it in its original packaging and out of the sight and reach of children and pets.