Oxramet G Xr 10/2/1000

OXRAMET G XR 10/2/1000

OXRAMET G XR 10/2/1000 is an extended-release, triple-combination oral antidiabetic medication used for the management of Type 2 Diabetes Mellitus. It is manufactured by Sun Pharmaceutical Industries Ltd.

Composition

Each tablet contains:

• Dapagliflozin: 10 mg (a sodium-glucose cotransporter-2 (SGLT2) inhibitor)
• Glimepiride: 2 mg (a sulfonylurea)
• Metformin Hydrochloride: 1000 mg (an extended-release biguanide)

Uses

OXRAMET G XR 10/2/1000 is prescribed to adults with Type 2 Diabetes Mellitus to help control high blood sugar levels when lifestyle changes and other monotherapies or dual therapies are insufficient. Its comprehensive action aims to improve glycemic control by enhancing insulin secretion, improving the body's response to insulin, and increasing the elimination of excess glucose through urine. This medication may also help prevent or delay diabetes-related complications such as kidney damage, blindness, nerve problems, and reduce the risk of cardiovascular events like heart attack and stroke.

Dosage and Administration

This medication should be taken exactly as prescribed by your doctor. It is typically taken once daily, preferably in the morning, with food to minimize gastrointestinal upset. The tablet should be swallowed whole and not crushed, broken, or chewed. Do not exceed the recommended dose.

Side Effects

Common Side Effects:

• Nausea, vomiting, diarrhea, abdominal pain
• Headache, dizziness
• Hypoglycemia (low blood sugar), loss of appetite, metallic taste
• Genital mycotic infections, urinary tract infections, increased urination
• Nasopharyngitis, fatigue, constipation, upper respiratory tract infection, muscle pain, back pain

Serious Side Effects (Consult your doctor if you experience any of these):

• Lactic acidosis (a rare but serious buildup of lactic acid in the blood)
• Severe urinary tract infections
• Liver problems (e.g., jaundice, hepatitis)
• Decreased vitamin B12 absorption, anemia
• Stevens-Johnson syndrome (a severe skin reaction)
• Allergic reactions (e.g., rash, itching, swelling of the face, lips, tongue, or throat)

Precautions

• Allergies: Do not take if you are allergic to dapagliflozin, glimepiride, metformin, or any other components of the tablet, or if you have a sulfa allergy.
• Contraindications: Not recommended for individuals with Type 1 Diabetes Mellitus, severe kidney disease (eGFR below 30 mL/min), severe liver disease, bladder cancer, severe heart failure, lactic acidosis, severe low blood pressure, severe dehydration, or diabetic ketoacidosis.
• Pregnancy and Breastfeeding: Limited information is available for use during pregnancy and breastfeeding. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Alcohol Consumption: Avoid excessive alcohol consumption as it significantly increases the risk of hypoglycemia and lactic acidosis.
• Kidney and Liver Function: Use with caution in patients with kidney or liver problems. Your doctor may adjust the dose or suggest alternatives based on your condition.
• Children: Not recommended for use in children below 18 years of age.
• Driving and Machinery: Your ability to drive or operate machinery may be affected if your blood sugar levels are too low or too high.
• Drug Interactions: Inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid potential interactions, especially with diuretics, insulin, and other insulin secretagogues.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is recommended during therapy.

Storage

Store in a cool and dry place, protected from direct sunlight and moisture. Keep out of the sight and reach of children. Optimal storage temperature is typically between 10ºC to 25ºC or below 30ºC. Do not use the medicine after the expiry date.

What is OXRAMET G XR 10/2/1000 used for?

OXRAMET G XR 10/2/1000 is an antidiabetic medicine primarily used to manage Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels, especially when lifestyle changes and other diabetes medications alone are not sufficient. Additionally, it may help prevent or delay diabetes-related complications such as kidney damage, nerve problems, vision loss, and reduce the risk of heart attack or stroke in people with Type 2 diabetes who also have heart disease.

How does OXRAMET G XR 10/2/1000 work to control blood sugar?

This medication is a combination of three active ingredients: Dapagliflozin, Metformin, and Glimepiride, each working through different mechanisms to control blood sugar levels.

• Dapagliflozin (a sodium-glucose cotransporter-2 inhibitor or SGLT2 inhibitor) works by preventing the kidneys from reabsorbing glucose back into the blood, leading to the excretion of excess sugar through urine.
• Metformin (a biguanide) primarily reduces glucose production in the liver and improves the body's sensitivity to insulin, allowing cells to use glucose more effectively. It also delays sugar absorption from the intestines.
• Glimepiride (a sulfonylurea) stimulates the beta cells in the pancreas to release more insulin, which helps lower blood glucose levels.

What is the usual dosage for OXRAMET G XR 10/2/1000?

OXRAMET G XR 10/2/1000 should be taken exactly as prescribed by your doctor. It is typically recommended to be taken once daily, preferably with food to help reduce stomach upset, and swallowed whole without crushing, breaking, or chewing. Do not exceed the prescribed dose.

What are the possible side effects of OXRAMET G XR 10/2/1000?

Common side effects can include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, loss of appetite, and urinary tract infections. Some individuals may also experience genital mycotic (fungal) infections or increased urination. Serious but less common side effects can include lactic acidosis (a rare but serious buildup of lactic acid in the blood), severe urinary tract infections, and allergic reactions. If side effects persist or worsen, consult your doctor.

Is OXRAMET G XR 10/2/1000 safe during pregnancy or breastfeeding?

OXRAMET G XR 10/2/1000 is generally not recommended during pregnancy or breastfeeding. Limited information is available regarding its use in these situations, and animal studies have shown potential harmful effects on the developing baby. Always inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medicine.

Can OXRAMET G XR 10/2/1000 be taken with other medications?

It is crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid potential drug interactions.

• Insulin and other anti-diabetic medicines (e.g., gliclazide, pioglitazone) may increase the risk of hypoglycemia (low blood sugar) when taken with OXRAMET G XR 10/2/1000.
• Diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• Corticosteroids (e.g., prednisolone, dexamethasone) may decrease the blood sugar-lowering effect of the medicine.
• Iodinated contrast agents (used in some X-ray procedures) should not be used with this medicine.
• Carbonic anhydrase inhibitors (e.g., acetazolamide, topiramate) may increase the risk of lactic acidosis.

What precautions should be taken?

• Alcohol: Avoid alcohol consumption while taking this medication as it increases the risk of hypoglycemia and lactic acidosis.
• Kidney and Liver Disease: Use with caution in patients with kidney or liver problems, as dose adjustments may be necessary. It is contraindicated in severe kidney or liver disease.
• Hydration: Stay well-hydrated throughout the day, as this medicine may increase urination and raise the risk of dehydration.
• Allergies: Do not take if you are allergic to dapagliflozin, glimepiride, metformin, or any other component of the tablet, or if you have a sulfa (sulfonamide) allergy.
• Blood Sugar Monitoring: Regular monitoring of blood glucose levels is essential.
• Type 1 Diabetes: This medicine is not for individuals with Type 1 diabetes.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

Store OXRAMET G XR 10/2/1000 in a cool, dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. The typical storage temperature is between 10ºC to 25ºC or below 30ºC. Do not use the medicine after the expiry date.