Brevipil Inj 10mg

BREVIPIL INJ 10MG

BREVIPIL INJ 10MG is an antiepileptic medication manufactured by SUN PHARMA LABORATORIES LTD., used in the management of seizures.

• Name

  • Brand Name: Brevipil Injection
  • Common Name: Brivaracetam

• Composition

  • Active Ingredient: Brivaracetam (10mg/ml)

• Uses BREVIPIL INJ is primarily prescribed for the treatment of partial-onset seizures associated with epilepsy. It can be used alone in adults or as an add-on therapy with other medications for adults, adolescents, and children from one month of age. The medication works by suppressing abnormal electrical activity in the brain, thereby helping to control the frequency and severity of seizures.

• Dosage and Administration BREVIPIL INJ is administered parenterally, typically as an intravenous injection over 2 to 15 minutes by a healthcare professional. The dosage is determined by a doctor based on the patient's age and weight. For adults (16 years and older), a common starting dose is 50 mg twice daily (100 mg/day), which can be adjusted based on individual response and tolerability, usually not exceeding 100 mg twice daily. For pediatric patients, the dosage is weight-dependent. It is crucial to adhere to the prescribed dosage and administer the medicine at the same time each day to maximize its effectiveness.

• Side Effects

  • Common Side Effects: Drowsiness, sleepiness, dizziness, fatigue, nausea, vomiting, decreased appetite, stomach pain, diarrhea, flu-like symptoms, irritability, anxiety, constipation, headache, and vertigo. These often improve as the body adjusts to the medication.
  • Serious Side Effects: Some individuals may experience neuropsychiatric symptoms, including depression and thoughts of self-harm. Serious skin reactions, such as Stevens-Johnson syndrome, and allergic reactions like bronchospasm and angioedema, have also been reported. Immediate medical attention is required if such symptoms occur.

• Precautions

  • Do not stop taking BREVIPIL INJ abruptly, as this can worsen seizures.
  • Patients with kidney or liver issues, a history of depression, or suicidal thoughts should inform their doctor, as dose adjustments may be necessary, particularly for liver impairment. The medication is generally safe for kidney disease, except in end-stage renal disease.
  • Use during pregnancy and breastfeeding is generally not recommended unless deemed necessary by a doctor. Consult a healthcare professional if pregnant or breastfeeding.
  • Avoid alcohol consumption as it can increase the risk of side effects like drowsiness and dizziness.
  • Exercise caution when driving or operating machinery until you understand how the medication affects you, due to potential dizziness, drowsiness, or fatigue.
  • Inform your doctor about all other medications you are taking to avoid potential drug interactions, especially with rifampicin, St John's wort, other CNS depressants (which can increase sedation), and carbamazepine.
  • BREVIPIL INJ is not recommended for children under one month of age.

• Storage Store BREVIPIL INJ below 30°C, away from moisture and heat. Keep the medicine out of the sight and reach of children. Any unused portion of the injection vial contents or diluted solution (if stored for more than 4 hours at room temperature) should be discarded.

Here are the most frequently asked questions about BREVIPIL INJ 10MG (Brivaracetam), along with concise answers:

What is BREVIPIL INJ 10MG used for?

BREVIPIL INJ 10MG is primarily used to manage partial-onset seizures in individuals with epilepsy. It can be used alone or in conjunction with other anti-epileptic medications for adults, adolescents, and children over one month old. It is particularly useful when oral administration is not feasible.

How does BREVIPIL INJ 10MG work?

This medicine contains Brivaracetam, which is an anti-epileptic agent. It works by selectively binding to synaptic vesicle protein 2A (SV2A) in the brain. This action helps to regulate abnormal neuronal electrical activity and control the excessive spread of electrical impulses that lead to epileptic seizures.

What is the usual dosage of BREVIPIL INJ 10MG?

BREVIPIL INJ 10MG is administered parenterally (intravenously or intramuscularly) by a healthcare professional. For adults (16 years and older), the usual starting dosage for both monotherapy and adjunctive therapy is 50 mg twice daily (100 mg per day). This can be adjusted by your doctor between 25 mg to 100 mg twice daily (50-200 mg per day) based on your tolerance and therapeutic response. For pediatric patients (1 month to less than 16 years) weighing less than 50 kg, the dosage is determined based on body weight. The injection is typically used for a short period when oral medication cannot be taken.

What are the possible side effects of BREVIPIL INJ 10MG?

Common side effects include drowsiness, dizziness, fatigue, nausea, vomiting, irritability, anxiety, mood changes, decreased appetite, and headaches. More serious, though rare, side effects can include suicidal thoughts or behaviors and significant changes in behavior. If you experience persistent or concerning side effects, contact your doctor immediately.

Is BREVIPIL INJ 10MG safe during pregnancy or breastfeeding?

• Pregnancy: BREVIPIL INJ 10MG is generally not recommended during pregnancy unless your doctor considers it absolutely necessary and believes the benefits outweigh the potential risks. If you are pregnant or plan to become pregnant, it is crucial to discuss this with your doctor. A pregnancy registry is available to collect information on the safety of anti-epileptic drugs during pregnancy.
• Breastfeeding: Limited information suggests that Brivaracetam may pass into breast milk. Therefore, it is generally not recommended for breastfeeding mothers, or caution is advised. You should consult your doctor to determine if it is safe to use this medicine while breastfeeding. If used, infants should be monitored for effects such as drowsiness, agitation, and adequate weight gain.

Can BREVIPIL INJ 10MG be taken with other medications?

Yes, but with caution. BREVIPIL INJ 10MG may interact with certain other medications.

• Other Antiepileptic Drugs: Medicines like carbamazepine and phenytoin can affect the levels of Brivaracetam or its active metabolite.
• Antibiotics: Certain antibiotics, such as rifampin, may reduce the levels of Brivaracetam in your body.
• CNS Depressants: Taking BREVIPIL INJ 10MG with other Central Nervous System (CNS) depressants, including opioids, antidepressants, anti-anxiety medications, or alcohol, can increase side effects like drowsiness and sedation.
• Herbal Supplements: St. John's wort can also influence Brivaracetam levels. Always inform your doctor about all medications, vitamins, and herbal supplements you are taking to avoid potential interactions.

What precautions should be taken while using BREVIPIL INJ 10MG?

• Alcohol Consumption: Avoid alcohol, as it can increase the risk of drowsiness, dizziness, and potentially worsen side effects.
• Driving and Operating Machinery: This medicine can cause drowsiness, dizziness, and fatigue, which may impair your ability to drive or operate machinery safely. Exercise caution until you know how the medication affects you.
• Mental Health: Inform your doctor if you have a history of depression, mood changes, or suicidal thoughts, as the medication may affect your mood.
• Liver and Kidney Conditions: Use with caution if you have liver disease, as a dose adjustment may be necessary. It is not recommended for patients with end-stage renal disease undergoing dialysis. Inform your doctor about any existing kidney or liver conditions.
• Abrupt Discontinuation: Do not stop taking BREVIPIL INJ 10MG suddenly without consulting your doctor, as this can increase the risk of seizures or worsen them. Your doctor will gradually reduce the dose if discontinuation is necessary.

What happens if a dose of BREVIPIL INJ 10MG is missed?

BREVIPIL INJ 10MG is typically administered by a healthcare professional in a clinical setting. It is crucial to adhere to the prescribed schedule and not miss doses, as this can lead to a worsening of seizures. If you miss an appointment for your injection, contact your healthcare provider immediately to reschedule and receive the dose as soon as possible. Do not attempt to self-administer or adjust the dose.

How should BREVIPIL INJ 10MG be stored?

BREVIPIL INJ 10MG should be stored below 30°C (86°F) in a cool and dry place. Keep it away from direct sunlight, moisture, and heat. Ensure that the medicine is kept out of the reach and sight of children.